| MP:0000230 | abnormal blood pressure | "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1Mag,Tg(Lck-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2
|
| MP:0001147 | small testis | "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959] |
Show
Allelic Composition: LnpkUl/LnpkUl
Genetic Background: involves: C3H/HeJ * C57BL/6J * MOLF/Ei
|
| MP:0001153 | small seminiferous tubules | "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844] |
Show
Allelic Composition: LnpkUl/LnpkUl
Genetic Background: involves: C3H/HeJ * C57BL/6J * MOLF/Ei
|
| MP:0001155 | arrest of spermatogenesis | "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271] |
Show
Allelic Composition: LnpkUl/LnpkUl
Genetic Background: involves: C3H/HeJ * C57BL/6J * MOLF/Ei
|
| MP:0001157 | small seminal gland | "reduced size, compared to the norm, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: LnpkUl/LnpkUl
Genetic Background: involves: C3H/HeJ * C57BL/6J * MOLF/Ei
|
| MP:0001415 | increased exploration in new environment | "greater amount of time spent investigating new location" [J:28825] |
Show
Allelic Composition: Ryr2tm1Slh/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0001417 | decreased exploration in new environment | "less amount of time spent investigating a new location" [J:79870] |
Show
Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1Mag,Tg(Lck-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2
|
| MP:0001463 | abnormal spatial learning | "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University] |
Show
Allelic Composition: Ryr2tm1Slh/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0001544 | abnormal cardiovascular system physiology | "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Nodaltm4Rob/Nodaltm4Rob
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6
|
| MP:0001559 | hyperglycemia | "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ryr2tm1Slh/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0001751 | increased circulating luteinizing hormone level | "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: LnpkUl/LnpkUl
Genetic Background: involves: C3H/HeJ * C57BL/6J * MOLF/Ei
|
| MP:0001922 | reduced male fertility | "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340] |
Show
Allelic Composition: LnpkUl/LnpkUl
Genetic Background: involves: C3H/HeJ * C57BL/6J * MOLF/Ei
|
| MP:0001925 | male infertility | "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
Show
Allelic Composition: LnpkUl/LnpkUl
Genetic Background: involves: C3H/HeJ * C57BL/6J * MOLF/Ei
|
| MP:0001935 | reduced litter size | "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: LnpkUl/LnpkUl
Genetic Background: involves: C3H/HeJ * C57BL/6J * MOLF/Ei
|
| MP:0002063 | abnormal learning/memory/conditioning | "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ryr2tm1Slh/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0002078 | abnormal glucose homeostasis | "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ryr2tm1Slh/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0002079 | increased circulating insulin level | "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ryr2tm1Slh/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0002188 | small heart | "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044] |
Show
Allelic Composition: Nodaltm4Rob/Nodaltm4Rob
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6
Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: B6.129-Adra1btm1Cta Adra1atm1Pcs
|
| MP:0002216 | abnormal seminiferous tubule morphology | "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: LnpkUl/LnpkUl
Genetic Background: involves: C3H/HeJ * C57BL/6J * MOLF/Ei
|
| MP:0002702 | decreased circulating free fatty acid level | "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ryr2tm1Slh/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0002780 | decreased circulating testosterone level | "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: LnpkUl/LnpkUl
Genetic Background: involves: C3H/HeJ * C57BL/6J * MOLF/Ei
|
| MP:0002782 | abnormal testicular secretion | "malfunction of the production and/or release of hormones from testicular tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: LnpkUl/LnpkUl
Genetic Background: involves: C3H/HeJ * C57BL/6J * MOLF/Ei
|
| MP:0002784 | abnormal Sertoli cell morphology | "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: LnpkUl/LnpkUl
Genetic Background: involves: C3H/HeJ * C57BL/6J * MOLF/Ei
|
| MP:0002834 | decreased heart weight | "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
|
| MP:0002843 | decreased blood pressure | "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1Mag,Tg(Lck-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2
|
| MP:0002972 | abnormal cardiac muscle contractility | "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
|
| MP:0003026 | decreased vascular smooth muscle contraction | "reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission] |
Show
Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1Mag,Tg(Lck-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2
|
| MP:0003068 | enlarged kidney | "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
|
| MP:0003393 | decreased cardiac output | "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
|
| MP:0003461 | abnormal response to novel object | "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University] |
Show
Allelic Composition: Ryr2tm1Slh/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0003562 | abnormal beta cell physiology | "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ryr2tm1Slh/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0003823 | increased left ventricular developed pressure | "increase in the difference between left ventricular systolic and diastolic pressures" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
|
| MP:0003921 | abnormal left ventricle morphology | "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1Mag,Tg(Lck-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2
|
| MP:0004000 | impaired passive avoidance behavior | "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1Mag,Tg(Lck-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2
|
| MP:0004184 | abnormal baroreceptor physiology | "anomaly in the function of the sensory nerve endings found in the wall of the atria of the heart, vena cava, aortic arch and carotid sinus that are sensitive to changes in blood pressure" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1Mag,Tg(Lck-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2
|
| MP:0004215 | abnormal myocardial fiber physiology | "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
|
| MP:0004485 | increased response of heart to induced stress | "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
|
| MP:0004565 | small myocardial fiber | "decreased size of the cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: B6.129-Adra1btm1Cta Adra1atm1Pcs
|
| MP:0004852 | decreased testis weight | "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: LnpkUl/LnpkUl
Genetic Background: involves: C3H/HeJ * C57BL/6J * MOLF/Ei
|
| MP:0004901 | decreased male germ cell number | "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: LnpkUl/LnpkUl
Genetic Background: involves: C3H/HeJ * C57BL/6J * MOLF/Ei
|
| MP:0005140 | decreased cardiac muscle contractility | "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1Mag,Tg(Lck-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2
|
| MP:0005293 | impaired glucose tolerance | "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Ryr2tm1Slh/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0005331 | insulin resistance | "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ryr2tm1Slh/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0005333 | decreased heart rate | "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764] |
Show
Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1Mag,Tg(Lck-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2
Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
|
| MP:0005406 | abnormal heart size | "change from the norm in the physical magnitude of the cardiac muscle or any of its component structures" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
|
| MP:0005458 | increased percent body fat | "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Ryr2tm1Slh/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0005599 | increased cardiac muscle contractility | "greater than the normal ability of the heart muscle to shorten or to develop increased tension
" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
Show
Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
|
| MP:0005658 | susceptibility to diet-induced obesity | "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator] |
Show
Allelic Composition: Ryr2tm1Slh/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0005669 | increased circulating leptin level | "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751] |
Show
Allelic Composition: Ryr2tm1Slh/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0006138 | congestive heart failure | "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
|
| MP:0006264 | decreased systolic blood pressure | "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887] |
Show
Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1Mag,Tg(Lck-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2
|
| MP:0008280 | male germ cell apoptosis | "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: LnpkUl/LnpkUl
Genetic Background: involves: C3H/HeJ * C57BL/6J * MOLF/Ei
|
| MP:0009712 | impaired conditioned place preference behavior | "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ryr2tm1Slh/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0009750 | impaired behavioral response to addictive substance | "decreased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ryr2tm1Slh/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0009763 | increased sensitivity to induced morbidity/mortality | "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
|
| MP:0010399 | decreased skeletal muscle glycogen level | "less than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ryr2tm1Slh/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0010400 | increased liver glycogen level | "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ryr2tm1Slh/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0011952 | decreased cardiac stroke volume | "reduction in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith] |
Show
Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
|
| MP:0012106 | impaired exercise endurance | "impaired performance during controlled physical activity" [MGI:smb] |
Show
Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
|
