ENSMUSG00000058620


Mus musculus

Features
Gene ID: ENSMUSG00000058620
  
Biological name :Adra2b
  
Synonyms : Adra2b / adrenoceptor alpha 2B
  
Possible biological names infered from orthology : P18089
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F1
Gene start: 127363208
Gene end: 127367221
  
Corresponding Affymetrix probe sets: 10475800 (MoGene1.0st)   1439645_at (Mouse Genome 430 2.0 Array)   1450003_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071798
Ensembl peptide - ENSMUSP00000100539
NCBI entrez gene - 11552     See in Manteia.
MGI - MGI:87935
RefSeq - NM_009633
RefSeq Peptide - NP_033763
swissprot - F8VQ23
swissprot - Q925K6
Ensembl - ENSMUSG00000058620
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adra2bENSDARG00000102096Danio rerio
 FP236542.1ENSDARG00000116988Danio rerio
 ADRA2BENSG00000274286Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adra2c / Q01337 / Alpha-2C adrenergic receptor / P18825* / adrenoceptor alpha 2C*ENSMUSG0000004531847
Adra2a / adrenoceptor alpha 2A / P08913*ENSMUSG0000003371747
Adra1d / adrenoceptor alpha 1D / P25100*ENSMUSG0000002733527
Adra1b / adrenoceptor alpha 1B / P35368*ENSMUSG0000005054127
Adra1a / P97718 / Alpha-1A adrenergic receptor / P35348* / adrenoceptor alpha 1A*ENSMUSG0000004587526
Htr1d / Q61224 / 5-hydroxytryptamine (serotonin) receptor 1D / P28221* / 5-hydroxytryptamine receptor 1D*ENSMUSG0000007068725
Htr1b / P28334 / 5-hydroxytryptamine (serotonin) receptor 1B / P28222* / 5-hydroxytryptamine receptor 1B*ENSMUSG0000004951125
Htr1a / Q64264 / 5-hydroxytryptamine (serotonin) receptor 1A / P08908* / 5-hydroxytryptamine receptor 1A*ENSMUSG0000002172125
Htr7 / P32304 / 5-hydroxytryptamine (serotonin) receptor 7 / P34969* / 5-hydroxytryptamine receptor 7*ENSMUSG0000002479825
Htr1f / Q02284 / 5-hydroxytryptamine (serotonin) receptor 1F / P30939* / 5-hydroxytryptamine receptor 1F*ENSMUSG0000005078324
Htr5a / P30966 / 5-hydroxytryptamine (serotonin) receptor 5A / P47898* / 5-hydroxytryptamine receptor 5A*ENSMUSG0000003910623
Htr5b / 5-hydroxytryptamine (serotonin) receptor 5BENSMUSG0000005053423


Protein motifs (from Interpro)
Interpro ID Name
 IPR000207  Alpha 2B adrenoceptor
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR002233  Adrenoceptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0003056 regulation of vascular smooth muscle contraction IEA
 biological_processGO:0006940 regulation of smooth muscle contraction IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0019229 regulation of vasoconstriction IEA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0032148 activation of protein kinase B activity IEA
 biological_processGO:0035625 obsolete epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0070474 positive regulation of uterine smooth muscle contraction IEA
 biological_processGO:0071875 adrenergic receptor signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004935 adrenergic receptor activity IEA
 molecular_functionGO:0004938 alpha2-adrenergic receptor activity IEA
 molecular_functionGO:0051379 epinephrine binding IEA


Pathways (from Reactome)
Pathway description
Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
G alpha (i) signalling events
G alpha (z) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000250 abnormal vasoconstriction "anomalous narrowing of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aestm1Grid/Aestm1Grid,Notch1tm1Grid/Notch1+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0001179 thicker alveolar septa 
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aestm1Grid/Aestm1Grid,Notch1tm1Grid/Notch1+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aestm1Grid/Aestm1Grid,Notch1tm1Grid/Notch1+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0005631 decreased lung weight "less than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0011147 increased mesenchymal cell proliferation involved in lung development "increase in the expansion rate of a lung mesenchymal cell population by cell division" [MGI:anna]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / reaction / complex
 ENSMUSG00000040009 Gnaz / O70443 / guanine nucleotide binding protein, alpha z subunit / P19086* / G protein subunit alpha z*  / complex / reaction
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr