ENSMUSG00000024798


Mus musculus

Features
Gene ID: ENSMUSG00000024798
  
Biological name :Htr7
  
Synonyms : 5-hydroxytryptamine (serotonin) receptor 7 / Htr7 / P32304
  
Possible biological names infered from orthology : 5-hydroxytryptamine receptor 7 / P34969
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C2
Gene start: 35958734
Gene end: 36057507
  
Corresponding Affymetrix probe sets: 10467182 (MoGene1.0st)   1422235_at (Mouse Genome 430 2.0 Array)   1435332_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126150
Ensembl peptide - ENSMUSP00000131912
Ensembl peptide - ENSMUSP00000131517
Ensembl peptide - ENSMUSP00000128386
Ensembl peptide - ENSMUSP00000126847
Ensembl peptide - ENSMUSP00000097105
NCBI entrez gene - 15566     See in Manteia.
MGI - MGI:99841
RefSeq - XM_006526701
RefSeq - XM_017318067
RefSeq - XM_006526704
RefSeq - XM_006526702
RefSeq - NM_008315
RefSeq Peptide - NP_001334371
RefSeq Peptide - NP_032341
swissprot - P32304
swissprot - E9Q4Q7
swissprot - B6VJS2
swissprot - B6VJS3
swissprot - E9Q1X2
Ensembl - ENSMUSG00000024798
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO704724.1ENSDARG00000099854Danio rerio
 htr7aENSDARG00000056949Danio rerio
 HTR7ENSGALG00000040549Gallus gallus
 HTR7ENSG00000148680Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Htr1d / Q61224 / 5-hydroxytryptamine (serotonin) receptor 1D / P28221* / 5-hydroxytryptamine receptor 1D*ENSMUSG0000007068728
Htr1b / P28334 / 5-hydroxytryptamine (serotonin) receptor 1B / P28222* / 5-hydroxytryptamine receptor 1B*ENSMUSG0000004951128
Adra1d / adrenoceptor alpha 1D / P25100*ENSMUSG0000002733528
Adra1b / adrenoceptor alpha 1B / P35368*ENSMUSG0000005054128
Htr1f / Q02284 / 5-hydroxytryptamine (serotonin) receptor 1F / P30939* / 5-hydroxytryptamine receptor 1F*ENSMUSG0000005078327
Htr1a / Q64264 / 5-hydroxytryptamine (serotonin) receptor 1A / P08908* / 5-hydroxytryptamine receptor 1A*ENSMUSG0000002172127
Adra1a / P97718 / Alpha-1A adrenergic receptor / P35348* / adrenoceptor alpha 1A*ENSMUSG0000004587526
Htr5b / 5-hydroxytryptamine (serotonin) receptor 5BENSMUSG0000005053424
Adra2b / adrenoceptor alpha 2B / P18089*ENSMUSG0000005862024
Htr5a / P30966 / 5-hydroxytryptamine (serotonin) receptor 5A / P47898* / 5-hydroxytryptamine receptor 5A*ENSMUSG0000003910624
Adra2c / Q01337 / Alpha-2C adrenergic receptor / P18825* / adrenoceptor alpha 2C*ENSMUSG0000004531823
Adra2a / adrenoceptor alpha 2A / P08913*ENSMUSG0000003371723


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001069  5-Hydroxytryptamine 7 receptor
 IPR002231  5-hydroxytryptamine receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006939 smooth muscle contraction IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0042310 vasoconstriction IEA
 biological_processGO:0098664 G-protein coupled serotonin receptor signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004993 G-protein coupled serotonin receptor activity IEA
 molecular_functionGO:0030594 neurotransmitter receptor activity IBA
 molecular_functionGO:0051378 serotonin binding IBA


Pathways (from Reactome)
Pathway description
Serotonin receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001650 electrically induced seizures "high or low frequency electrical stimulation applied to induce seizure activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, wf:Wayne Frankel , TJL staff]
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Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abca1tm1Jdm/Abca1+
Genetic Background: DBA/1LacJ-Abca1tm1Jdm

Allelic Composition: Htr7tm1Mrg/Htr7tm1Mrg
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

 MP:0003858 enhanced coordination "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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