ENSMUSG00000039106


Mus musculus

Features
Gene ID: ENSMUSG00000039106
  
Biological name :Htr5a
  
Synonyms : 5-hydroxytryptamine (serotonin) receptor 5A / Htr5a / P30966
  
Possible biological names infered from orthology : 5-hydroxytryptamine receptor 5A / P47898
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B1
Gene start: 27842149
Gene end: 27855088
  
Corresponding Affymetrix probe sets: 10520355 (MoGene1.0st)   1422207_at (Mouse Genome 430 2.0 Array)   1443276_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038884
NCBI entrez gene - 15563     See in Manteia.
MGI - MGI:96283
RefSeq - NM_008314
RefSeq - XM_006535631
RefSeq Peptide - NP_032340
swissprot - P30966
Ensembl - ENSMUSG00000039106
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 htr5aaENSDARG00000038869Danio rerio
 htr5abENSDARG00000068557Danio rerio
 HTR5AENSGALG00000006362Gallus gallus
 HTR5AENSG00000157219Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Htr5b / 5-hydroxytryptamine (serotonin) receptor 5BENSMUSG0000005053468
Htr1f / Q02284 / 5-hydroxytryptamine (serotonin) receptor 1F / P30939* / 5-hydroxytryptamine receptor 1F*ENSMUSG0000005078334
Htr1a / Q64264 / 5-hydroxytryptamine (serotonin) receptor 1A / P08908* / 5-hydroxytryptamine receptor 1A*ENSMUSG0000002172134
Htr1d / Q61224 / 5-hydroxytryptamine (serotonin) receptor 1D / P28221* / 5-hydroxytryptamine receptor 1D*ENSMUSG0000007068733
Htr1b / P28334 / 5-hydroxytryptamine (serotonin) receptor 1B / P28222* / 5-hydroxytryptamine receptor 1B*ENSMUSG0000004951133
Htr7 / P32304 / 5-hydroxytryptamine (serotonin) receptor 7 / P34969* / 5-hydroxytryptamine receptor 7*ENSMUSG0000002479831
Adra2c / Q01337 / Alpha-2C adrenergic receptor / P18825* / adrenoceptor alpha 2C*ENSMUSG0000004531831
Adra1b / adrenoceptor alpha 1B / P35368*ENSMUSG0000005054130
Adra2a / adrenoceptor alpha 2A / P08913*ENSMUSG0000003371730
Adra1a / P97718 / Alpha-1A adrenergic receptor / P35348* / adrenoceptor alpha 1A*ENSMUSG0000004587529
Adra2b / adrenoceptor alpha 2B / P18089*ENSMUSG0000005862029
Adra1d / adrenoceptor alpha 1D / P25100*ENSMUSG0000002733527


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001397  5-Hydroxytryptamine 5A receptor
 IPR002231  5-hydroxytryptamine receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA
 biological_processGO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0019933 cAMP-mediated signaling IDA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0032355 response to estradiol IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043204 perikaryon IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004993 G-protein coupled serotonin receptor activity ISO
 molecular_functionGO:0030594 neurotransmitter receptor activity IBA
 molecular_functionGO:0051378 serotonin binding IBA


Pathways (from Reactome)
Pathway description
Serotonin receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Lalbatm1Jvt/Lalba+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003107 abnormal response to novelty "alteration in amount of exploration/investigation of a novel object, situation or environment" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Lalbatm1Jvt/Lalba+
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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