ENSMUSG00000049511


Mus musculus

Features
Gene ID: ENSMUSG00000049511
  
Biological name :Htr1b
  
Synonyms : 5-hydroxytryptamine (serotonin) receptor 1B / Htr1b / P28334
  
Possible biological names infered from orthology : 5-hydroxytryptamine receptor 1B / P28222
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: E1
Gene start: 81628291
Gene end: 81633828
  
Corresponding Affymetrix probe sets: 10595324 (MoGene1.0st)   1422288_at (Mouse Genome 430 2.0 Array)   1442077_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050898
Ensembl peptide - ENSMUSP00000139389
NCBI entrez gene - 15551     See in Manteia.
MGI - MGI:96274
RefSeq - NM_010482
RefSeq Peptide - NP_034612
swissprot - P28334
swissprot - Q0VES5
Ensembl - ENSMUSG00000049511
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 htr1bENSDARG00000053987Danio rerio
 HTR1BENSGALG00000015895Gallus gallus
 HTR1BENSG00000135312Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Htr1d / Q61224 / 5-hydroxytryptamine (serotonin) receptor 1D / P28221* / 5-hydroxytryptamine receptor 1D*ENSMUSG0000007068760
Htr1f / Q02284 / 5-hydroxytryptamine (serotonin) receptor 1F / P30939* / 5-hydroxytryptamine receptor 1F*ENSMUSG0000005078343
Htr1a / Q64264 / 5-hydroxytryptamine (serotonin) receptor 1A / P08908* / 5-hydroxytryptamine receptor 1A*ENSMUSG0000002172141
Htr7 / P32304 / 5-hydroxytryptamine (serotonin) receptor 7 / P34969* / 5-hydroxytryptamine receptor 7*ENSMUSG0000002479834
Adra2c / Q01337 / Alpha-2C adrenergic receptor / P18825* / adrenoceptor alpha 2C*ENSMUSG0000004531831
Htr5b / 5-hydroxytryptamine (serotonin) receptor 5BENSMUSG0000005053431
Htr5a / P30966 / 5-hydroxytryptamine (serotonin) receptor 5A / P47898* / 5-hydroxytryptamine receptor 5A*ENSMUSG0000003910631
Adra2a / adrenoceptor alpha 2A / P08913*ENSMUSG0000003371731
Adra1b / adrenoceptor alpha 1B / P35368*ENSMUSG0000005054130
Adra2b / adrenoceptor alpha 2B / P18089*ENSMUSG0000005862030
Adra1a / P97718 / Alpha-1A adrenergic receptor / P35348* / adrenoceptor alpha 1A*ENSMUSG0000004587529
Adra1d / adrenoceptor alpha 1D / P25100*ENSMUSG0000002733528


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR002147  5-Hydroxytryptamine 1B receptor
 IPR002231  5-hydroxytryptamine receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002031 G-protein coupled receptor internalization IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway ISO
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IMP
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0007610 behavior IEA
 biological_processGO:0007631 feeding behavior IEA
 biological_processGO:0014059 regulation of dopamine secretion IEA
 biological_processGO:0014063 negative regulation of serotonin secretion IMP
 biological_processGO:0032229 negative regulation of synaptic transmission, GABAergic IEA
 biological_processGO:0035690 cellular response to drug ISS
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042310 vasoconstriction IEA
 biological_processGO:0042493 response to drug IDA
 biological_processGO:0042756 drinking behavior IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0046849 bone remodeling IGI
 biological_processGO:0050795 regulation of behavior IEA
 biological_processGO:0051385 response to mineralocorticoid IEA
 biological_processGO:0051967 negative regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0071312 cellular response to alkaloid ISO
 biological_processGO:0071502 cellular response to temperature stimulus IDA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation ISO
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004993 G-protein coupled serotonin receptor activity IDA
 molecular_functionGO:0008144 drug binding IDA
 molecular_functionGO:0030594 neurotransmitter receptor activity IBA
 molecular_functionGO:0051378 serotonin binding IDA


Pathways (from Reactome)
Pathway description
Serotonin receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
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Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0001354 increased aggression towards males "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward male mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Htr1btm1.1(KOMP)Vlcg/Htr1b+
Genetic Background: C57BL/6N-Htr1btm1.1(KOMP)Vlcg/J

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Htr1btm1Rhn/Htr1btm1Rhn,Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002803 abnormal operant conditional behavior "defects in the operant conditioning system refers to abnormalities in scheduled controlled behavior; behavioral assessment occurs in an automated chamber where responses are reinforced with food" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Dido1tm1Cmar/Dido1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Htr1btm1Rhn/Htr1btm1Rhn,Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0003958 heart valve hyperplasia "increased number of cells of the heart valves, leading to increased size or bulk" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:60214]
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Allelic Composition: Htr1btm1Rhn/Htr1btm1Rhn,Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Htr1btm1.1(KOMP)Vlcg/Htr1b+
Genetic Background: C57BL/6N-Htr1btm1.1(KOMP)Vlcg/J

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Htr1btm1Rhn/Htr1b+
Genetic Background: involves: 129S2/SvPas

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Htr1btm1Rhn/Htr1btm1Rhn,Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Htr1btm1Rhn/Htr1b+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Htr1btm1Rhn/Htr1b+,Tph1tm1Kry/Tph1+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Htr1btm1.1(KOMP)Vlcg/Htr1b+
Genetic Background: C57BL/6N-Htr1btm1.1(KOMP)Vlcg/J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Htr1btm1.1(KOMP)Vlcg/Htr1b+
Genetic Background: C57BL/6N-Htr1btm1.1(KOMP)Vlcg/J

 MP:0011275 abnormal behavioral response to light "unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light" [GO:0009416, MGI:llw2]
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Allelic Composition: Htr1btm1.1(KOMP)Vlcg/Htr1b+
Genetic Background: C57BL/6N-Htr1btm1.1(KOMP)Vlcg/J

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0020039 increased bone ossification "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Htr1btm1Rhn/Htr1b+
Genetic Background: involves: 129S2/SvPas

 MP:0030438 increased osteoblast proliferation "increase in the expansion rate of osteoblasts by cell division; osteoblasts are skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell" [MGI:anna]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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