ENSMUSG00000045875


Mus musculus

Features
Gene ID: ENSMUSG00000045875
  
Biological name :Adra1a
  
Synonyms : Adra1a / Alpha-1A adrenergic receptor / P97718
  
Possible biological names infered from orthology : adrenoceptor alpha 1A / P35348
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: D1
Gene start: 66635251
Gene end: 66771168
  
Corresponding Affymetrix probe sets: 10416099 (MoGene1.0st)   1421659_at (Mouse Genome 430 2.0 Array)   1459351_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125354
Ensembl peptide - ENSMUSP00000124322
Ensembl peptide - ENSMUSP00000124570
Ensembl peptide - ENSMUSP00000053703
Ensembl peptide - ENSMUSP00000153103
NCBI entrez gene - 11549     See in Manteia.
MGI - MGI:104773
RefSeq - XM_017315802
RefSeq - NM_001271759
RefSeq - NM_001271760
RefSeq - NM_001271761
RefSeq - NM_013461
RefSeq - XM_006518449
RefSeq - XM_011244923
RefSeq - XM_011244924
RefSeq - XM_011244925
RefSeq - XM_011244926
RefSeq - XM_017315800
RefSeq - XM_017315801
RefSeq - XM_006518444
RefSeq Peptide - NP_001258690
RefSeq Peptide - NP_038489
RefSeq Peptide - NP_001258688
RefSeq Peptide - NP_001258689
swissprot - P97718
swissprot - Q8BUE5
swissprot - Q8BXZ4
Ensembl - ENSMUSG00000045875
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adra1aaENSDARG00000028725Danio rerio
 adra1abENSDARG00000027638Danio rerio
 ADRA1AENSGALG00000000469Gallus gallus
 ADRA1AENSG00000120907Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adra1b / adrenoceptor alpha 1B / P35368*ENSMUSG0000005054149
Adra1d / adrenoceptor alpha 1D / P25100*ENSMUSG0000002733545
Htr7 / P32304 / 5-hydroxytryptamine (serotonin) receptor 7 / P34969* / 5-hydroxytryptamine receptor 7*ENSMUSG0000002479826
Adra2b / adrenoceptor alpha 2B / P18089*ENSMUSG0000005862025
Htr1f / Q02284 / 5-hydroxytryptamine (serotonin) receptor 1F / P30939* / 5-hydroxytryptamine receptor 1F*ENSMUSG0000005078325
Adra2c / Q01337 / Alpha-2C adrenergic receptor / P18825* / adrenoceptor alpha 2C*ENSMUSG0000004531825
Htr1a / Q64264 / 5-hydroxytryptamine (serotonin) receptor 1A / P08908* / 5-hydroxytryptamine receptor 1A*ENSMUSG0000002172125
Htr1b / P28334 / 5-hydroxytryptamine (serotonin) receptor 1B / P28222* / 5-hydroxytryptamine receptor 1B*ENSMUSG0000004951124
Htr1d / Q61224 / 5-hydroxytryptamine (serotonin) receptor 1D / P28221* / 5-hydroxytryptamine receptor 1D*ENSMUSG0000007068724
Adra2a / adrenoceptor alpha 2A / P08913*ENSMUSG0000003371724
Htr5a / P30966 / 5-hydroxytryptamine (serotonin) receptor 5A / P47898* / 5-hydroxytryptamine receptor 5A*ENSMUSG0000003910622
Htr5b / 5-hydroxytryptamine (serotonin) receptor 5BENSMUSG0000005053421


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001004  Alpha 1A adrenoceptor
 IPR002233  Adrenoceptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001985 negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure IMP
 biological_processGO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IMP
 biological_processGO:0001996 positive regulation of heart rate by epinephrine-norepinephrine IGI
 biological_processGO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine IGI
 biological_processGO:0003084 positive regulation of systemic arterial blood pressure IEA
 biological_processGO:0006937 regulation of muscle contraction IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007202 activation of phospholipase C activity IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0007512 adult heart development IGI
 biological_processGO:0007568 aging IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0010460 positive regulation of heart rate IEA
 biological_processGO:0010507 negative regulation of autophagy IDA
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IDA
 biological_processGO:0019229 regulation of vasoconstriction IEA
 biological_processGO:0032230 positive regulation of synaptic transmission, GABAergic IEA
 biological_processGO:0035024 negative regulation of Rho protein signal transduction ISO
 biological_processGO:0035265 organ growth IGI
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043410 positive regulation of MAPK cascade ISO
 biological_processGO:0045760 positive regulation of action potential IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IBA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IDA
 biological_processGO:0055117 regulation of cardiac muscle contraction IEA
 biological_processGO:0060073 micturition IEA
 biological_processGO:0060402 calcium ion transport into cytosol IEA
 biological_processGO:0060452 positive regulation of cardiac muscle contraction IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071875 adrenergic receptor signaling pathway IEA
 biological_processGO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway IBA
 biological_processGO:0090037 positive regulation of protein kinase C signaling IEA
 biological_processGO:0097195 pilomotor reflex IDA
 biological_processGO:1903997 positive regulation of non-membrane spanning protein tyrosine kinase activity IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0030315 T-tubule IEA
 cellular_componentGO:0031965 nuclear membrane ISS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004935 adrenergic receptor activity IEA
 molecular_functionGO:0004937 alpha1-adrenergic receptor activity ISO
 molecular_functionGO:0046982 protein heterodimerization activity ISS


Pathways (from Reactome)
Pathway description
Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nodaltm4Rob/Nodaltm4Rob
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6

 MP:0001596 hypotension "sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Adra1atm1Pcs/Adra1a+
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Nodaltm4Rob/Nodaltm4Rob
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6

Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: B6.129-Adra1btm1Cta Adra1atm1Pcs

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002972 abnormal cardiac muscle contractility "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0003026 decreased vascular smooth muscle contraction "reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0003393 decreased cardiac output "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0003823 increased left ventricular developed pressure "increase in the difference between left ventricular systolic and diastolic pressures" [RGD:Rat Genome Database submission]
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Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0003929 decreased heart rate variability "reduced variation of beat-to-beat intervals of the heart, usually indicitive of cardiac disease" [RGD:Rat Genome Database submission]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0004565 small myocardial fiber "decreased size of the cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: B6.129-Adra1btm1Cta Adra1atm1Pcs

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Nodaltm4Rob/Nodaltm4Rob
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6

 MP:0005406 abnormal heart size "change from the norm in the physical magnitude of the cardiac muscle or any of its component structures" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0005599 increased cardiac muscle contractility "greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0011952 decreased cardiac stroke volume "reduction in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]
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Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
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Allelic Composition: Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000149 Gna12 / P27600 / guanine nucleotide binding protein, alpha 12 / Q03113* / G protein subunit alpha 12*  / reaction / complex
 ENSMUSG00000020611 Gna13 / P27601 / guanine nucleotide binding protein, alpha 13 / Q14344* / G protein subunit alpha 13*  / complex / reaction
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / complex / reaction
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / reaction / complex






 

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