ENSMUSG00000021721


Mus musculus

Features
Gene ID: ENSMUSG00000021721
  
Biological name :Htr1a
  
Synonyms : 5-hydroxytryptamine (serotonin) receptor 1A / Htr1a / Q64264
  
Possible biological names infered from orthology : 5-hydroxytryptamine receptor 1A / P08908
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: D1
Gene start: 105443639
Gene end: 105448122
  
Corresponding Affymetrix probe sets: 10407034 (MoGene1.0st)   1438710_at (Mouse Genome 430 2.0 Array)   1450219_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022235
NCBI entrez gene - 15550     See in Manteia.
MGI - MGI:96273
RefSeq - NM_008308
RefSeq Peptide - NP_032334
swissprot - Q64264
Ensembl - ENSMUSG00000021721
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 htr1aaENSDARG00000093745Danio rerio
 HTR1AENSGALG00000014742Gallus gallus
 HTR1AENSG00000178394Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Htr1b / P28334 / 5-hydroxytryptamine (serotonin) receptor 1B / P28222* / 5-hydroxytryptamine receptor 1B*ENSMUSG0000004951138
Htr1d / Q61224 / 5-hydroxytryptamine (serotonin) receptor 1D / P28221* / 5-hydroxytryptamine receptor 1D*ENSMUSG0000007068737
Htr1f / Q02284 / 5-hydroxytryptamine (serotonin) receptor 1F / P30939* / 5-hydroxytryptamine receptor 1F*ENSMUSG0000005078337
Htr7 / P32304 / 5-hydroxytryptamine (serotonin) receptor 7 / P34969* / 5-hydroxytryptamine receptor 7*ENSMUSG0000002479830
Adra2a / adrenoceptor alpha 2A / P08913*ENSMUSG0000003371730
Adra2c / Q01337 / Alpha-2C adrenergic receptor / P18825* / adrenoceptor alpha 2C*ENSMUSG0000004531830
Adra1b / adrenoceptor alpha 1B / P35368*ENSMUSG0000005054130
Htr5a / P30966 / 5-hydroxytryptamine (serotonin) receptor 5A / P47898* / 5-hydroxytryptamine receptor 5A*ENSMUSG0000003910629
Adra1d / adrenoceptor alpha 1D / P25100*ENSMUSG0000002733528
Adra1a / P97718 / Alpha-1A adrenergic receptor / P35348* / adrenoceptor alpha 1A*ENSMUSG0000004587528
Htr5b / 5-hydroxytryptamine (serotonin) receptor 5BENSMUSG0000005053428
Adra2b / adrenoceptor alpha 2B / P18089*ENSMUSG0000005862027


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000610  5-Hydroxytryptamine 1A receptor
 IPR002231  5-hydroxytryptamine receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway IEA
 biological_processGO:0007210 serotonin receptor signaling pathway IMP
 biological_processGO:0007610 behavior IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0014062 regulation of serotonin secretion IMP
 biological_processGO:0035640 exploration behavior IMP
 biological_processGO:0042053 regulation of dopamine metabolic process IMP
 biological_processGO:0042310 vasoconstriction IEA
 biological_processGO:0042428 serotonin metabolic process IMP
 biological_processGO:0046883 regulation of hormone secretion IEA
 biological_processGO:0050795 regulation of behavior IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004993 G-protein coupled serotonin receptor activity IMP
 molecular_functionGO:0030594 neurotransmitter receptor activity IBA
 molecular_functionGO:0051378 serotonin binding IBA
 molecular_functionGO:0090722 receptor-receptor interaction IEA


Pathways (from Reactome)
Pathway description
Serotonin receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: involves: C57BL/6

Allelic Composition: Htr1atm1Tct/Htr1a+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Htr1atm1Toth/Htr1atm1Toth
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Htr1atm1Rhn/Htr1atm1Rhn
Genetic Background: involves: 129S1/Sv

Allelic Composition: Htr1atm1Rhn/Htr1a+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Htr1atm1Toth/Htr1a+
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Htr1atm1Rhn/Htr1atm1Rhn
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Htr1atm1Toth/Htr1atm1Toth
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Htr1atm1Toth/Htr1atm1Toth
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crb1tm1Wij/Crb1+,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Htr1atm1Rhn/Htr1atm1Rhn
Genetic Background: involves: 129S1/Sv

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: involves: C57BL/6

Allelic Composition: Htr1atm1Tct/Htr1a+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Htr1atm1Rhn/Htr1atm1Rhn
Genetic Background: involves: 129S1/Sv

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: involves: C57BL/6

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Htr1atm1Toth/Htr1atm1Toth
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0002920 reduced paired-pulse facilitation "decrease in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Htr1atm1Toth/Htr1atm1Toth
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Htr1atm1Rhn/Htr1atm1Rhn
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

 MP:0005322 abnormal serotonin level "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Htr1atm1Rhn/Htr1atm1Rhn
Genetic Background: involves: 129S1/Sv

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

 MP:0005663 abnormal circulating noradrenaline level "aberrant blood concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Htr1atm1Rhn/Htr1atm1Rhn
Genetic Background: involves: 129S1/Sv

 MP:0006276 abnormal autonomic nervous system physiology "anomaly in the function of the sensory and motor neurons that run between the central nervous system (especially the hypothalamus and medulla oblongata) and various internal organs (heart, lungs, endocrine and exocrine glands), responsible for controling involuntary bodily functions" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

 MP:0011275 abnormal behavioral response to light "unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light" [GO:0009416, MGI:llw2]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0012287 increased frequency of paradoxical sleep "increased incidence or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Crb1tm1Wij/Crb1+,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

 MP:0012291 increased slow-wave sleep duration "increased length of time of the third, or deep sleep stage of NREM sleep" [MGI:csmith]
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Allelic Composition: Crb1tm1Wij/Crb1+,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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