ENSMUSG00000033717


Mus musculus

Features
Gene ID: ENSMUSG00000033717
  
Biological name :Adra2a
  
Synonyms : Adra2a / adrenoceptor alpha 2A
  
Possible biological names infered from orthology : P08913
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: D2
Gene start: 54045182
Gene end: 54048982
  
Corresponding Affymetrix probe sets: 10464030 (MoGene1.0st)   1423022_at (Mouse Genome 430 2.0 Array)   1433600_at (Mouse Genome 430 2.0 Array)   1433601_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036203
NCBI entrez gene - 11551     See in Manteia.
MGI - MGI:87934
RefSeq - NM_007417
RefSeq Peptide - NP_031443
swissprot - Q3URE6
Ensembl - ENSMUSG00000033717
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adra2aENSDARG00000040841Danio rerio
 ADRA2AENSGALG00000023521Gallus gallus
 ADRA2AENSG00000150594Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adra2c / Q01337 / Alpha-2C adrenergic receptor / P18825* / adrenoceptor alpha 2C*ENSMUSG0000004531852
Adra2b / adrenoceptor alpha 2B / P18089*ENSMUSG0000005862046
Htr1a / Q64264 / 5-hydroxytryptamine (serotonin) receptor 1A / P08908* / 5-hydroxytryptamine receptor 1A*ENSMUSG0000002172128
Htr1f / Q02284 / 5-hydroxytryptamine (serotonin) receptor 1F / P30939* / 5-hydroxytryptamine receptor 1F*ENSMUSG0000005078326
Htr1b / P28334 / 5-hydroxytryptamine (serotonin) receptor 1B / P28222* / 5-hydroxytryptamine receptor 1B*ENSMUSG0000004951126
Htr1d / Q61224 / 5-hydroxytryptamine (serotonin) receptor 1D / P28221* / 5-hydroxytryptamine receptor 1D*ENSMUSG0000007068726
Adra1b / adrenoceptor alpha 1B / P35368*ENSMUSG0000005054125
Adra1d / adrenoceptor alpha 1D / P25100*ENSMUSG0000002733525
Adra1a / P97718 / Alpha-1A adrenergic receptor / P35348* / adrenoceptor alpha 1A*ENSMUSG0000004587524
Htr5a / P30966 / 5-hydroxytryptamine (serotonin) receptor 5A / P47898* / 5-hydroxytryptamine receptor 5A*ENSMUSG0000003910623
Htr7 / P32304 / 5-hydroxytryptamine (serotonin) receptor 7 / P34969* / 5-hydroxytryptamine receptor 7*ENSMUSG0000002479823
Htr5b / 5-hydroxytryptamine (serotonin) receptor 5BENSMUSG0000005053423


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001946  Alpha 2A adrenoceptor
 IPR002233  Adrenoceptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001819 positive regulation of cytokine production IEA
 biological_processGO:0006940 regulation of smooth muscle contraction IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0019229 regulation of vasoconstriction IEA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032148 activation of protein kinase B activity IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0035625 obsolete epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0045741 positive regulation of epidermal growth factor-activated receptor activity IEA
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0050995 negative regulation of lipid catabolic process IEA
 biological_processGO:0051044 positive regulation of membrane protein ectodomain proteolysis IEA
 biological_processGO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0071875 adrenergic receptor signaling pathway IEA
 biological_processGO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway IEA
 biological_processGO:0071882 phospholipase C-activating adrenergic receptor signaling pathway IEA
 biological_processGO:0090303 positive regulation of wound healing IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004935 adrenergic receptor activity IEA
 molecular_functionGO:0004938 alpha2-adrenergic receptor activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031696 alpha-2C adrenergic receptor binding IEA
 molecular_functionGO:0031996 thioesterase binding IEA
 molecular_functionGO:0032795 heterotrimeric G-protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0051379 epinephrine binding IEA
 molecular_functionGO:0051380 norepinephrine binding IEA


Pathways (from Reactome)
Pathway description
Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: F2rl1tm1Mslb/F2rl1tm1Mslb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Adra2atm1Lel/Adra2atm1Lel
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Adgrb1tm2a(EUCOMM)Wtsi/Adgrb1+
Genetic Background: C57BL/6N-Adgrb1tm2a(EUCOMM)Wtsi/Wtsi

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: F2rl1tm1Mslb/F2rl1tm1Mslb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hhextm1Jomb/Hhextm1Jomb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Adgrb1tm2a(EUCOMM)Wtsi/Adgrb1+
Genetic Background: C57BL/6N-Adgrb1tm2a(EUCOMM)Wtsi/Wtsi

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0005447 abnormal synaptic norepinephrine release "aberrant secretion across synapses of this widespread central and autonomic neurotransmitter, the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0008840 abnormal spike wave discharge "anomaly in the characteristic epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy" [PMID:16725200]
Show

Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgrb1tm2a(EUCOMM)Wtsi/Adgrb1+
Genetic Background: C57BL/6N-Adgrb1tm2a(EUCOMM)Wtsi/Wtsi

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Adgrb1tm2a(EUCOMM)Wtsi/Adgrb1+
Genetic Background: C57BL/6N-Adgrb1tm2a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000040009 Gnaz / O70443 / guanine nucleotide binding protein, alpha z subunit / P19086* / G protein subunit alpha z*  / complex / reaction
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / complex / reaction
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / reaction / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr