ENSG00000150594


Homo sapiens

Features
Gene ID: ENSG00000150594
  
Biological name :ADRA2A
  
Synonyms : ADRA2A / adrenoceptor alpha 2A / P08913
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q25.2
Gene start: 111077163
Gene end: 111080907
  
Corresponding Affymetrix probe sets: 209869_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000280155
NCBI entrez gene - 150     See in Manteia.
OMIM - 104210
RefSeq - NM_000681
RefSeq Peptide - NP_000672
swissprot - P08913
Ensembl - ENSG00000150594
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adra2aENSDARG00000040841Danio rerio
 ADRA2AENSGALG00000023521Gallus gallus
 Adra2aENSMUSG00000033717Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADRA2C / P18825 / adrenoceptor alpha 2CENSG0000018416052
ADRA2B / P18089 / adrenoceptor alpha 2BENSG0000027428647
HTR1A / P08908 / 5-hydroxytryptamine receptor 1AENSG0000017839426
HTR1D / P28221 / 5-hydroxytryptamine receptor 1DENSG0000017954626
HTR1B / P28222 / 5-hydroxytryptamine receptor 1BENSG0000013531226
ADRA1D / P25100 / adrenoceptor alpha 1DENSG0000017187325
ADRA1B / P35368 / adrenoceptor alpha 1BENSG0000017021425
HTR1E / P28566 / 5-hydroxytryptamine receptor 1EENSG0000016883025
HTR1F / P30939 / 5-hydroxytryptamine receptor 1FENSG0000017909725
ADRA1A / P35348 / adrenoceptor alpha 1AENSG0000012090724
HTR7 / P34969 / 5-hydroxytryptamine receptor 7ENSG0000014868023
HTR5A / P47898 / 5-hydroxytryptamine receptor 5AENSG0000015721923


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001946  Alpha 2A adrenoceptor
 IPR002233  Adrenoceptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001819 positive regulation of cytokine production IDA
 biological_processGO:0006940 regulation of smooth muscle contraction IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007265 Ras protein signal transduction TAS
 biological_processGO:0007266 Rho protein signal transduction TAS
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0010700 negative regulation of norepinephrine secretion TAS
 biological_processGO:0019229 regulation of vasoconstriction IEA
 biological_processGO:0030036 actin cytoskeleton organization TAS
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0032147 activation of protein kinase activity IDA
 biological_processGO:0032148 activation of protein kinase B activity IDA
 biological_processGO:0032811 negative regulation of epinephrine secretion NAS
 biological_processGO:0032870 cellular response to hormone stimulus IGI
 biological_processGO:0035625 obsolete epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway IDA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0043268 positive regulation of potassium ion transport ISS
 biological_processGO:0043406 positive regulation of MAP kinase activity IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0045741 positive regulation of epidermal growth factor-activated receptor activity IDA
 biological_processGO:0045955 negative regulation of calcium ion-dependent exocytosis IC
 biological_processGO:0046676 negative regulation of insulin secretion IMP
 biological_processGO:0050796 regulation of insulin secretion TAS
 biological_processGO:0050892 intestinal absorption TAS
 biological_processGO:0050995 negative regulation of lipid catabolic process IGI
 biological_processGO:0051044 positive regulation of membrane protein ectodomain proteolysis IDA
 biological_processGO:0051926 negative regulation of calcium ion transport ISS
 biological_processGO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
 biological_processGO:0071875 adrenergic receptor signaling pathway IDA
 biological_processGO:0071878 negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway ISS
 biological_processGO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway IBA
 biological_processGO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway IDA
 biological_processGO:0071882 phospholipase C-activating adrenergic receptor signaling pathway IDA
 biological_processGO:0090303 positive regulation of wound healing IMP
 biological_processGO:0106072 negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway ISS
 biological_processGO:1901020 negative regulation of calcium ion transmembrane transporter activity ISS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane TAS
 cellular_componentGO:0043235 receptor complex IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004935 adrenergic receptor activity IEA
 molecular_functionGO:0004938 alpha2-adrenergic receptor activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0031692 alpha-1B adrenergic receptor binding ISS
 molecular_functionGO:0031696 alpha-2C adrenergic receptor binding IPI
 molecular_functionGO:0031996 thioesterase binding IPI
 molecular_functionGO:0032795 heterotrimeric G-protein binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046982 protein heterodimerization activity ISS
 molecular_functionGO:0051379 epinephrine binding IDA
 molecular_functionGO:0051380 norepinephrine binding IDA


Pathways (from Reactome)
Pathway description
Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000128266 GNAZ / P19086 / G protein subunit alpha z  / complex / reaction
 ENSG00000186469 GNG2 / P59768 / G protein subunit gamma 2  / reaction / complex
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / reaction / complex






 

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