ENSG00000170214


Homo sapiens

Features
Gene ID: ENSG00000170214
  
Biological name :ADRA1B
  
Synonyms : ADRA1B / adrenoceptor alpha 1B / P35368
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q33.3
Gene start: 159865080
Gene end: 159972544
  
Corresponding Affymetrix probe sets: 207589_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000306662
Ensembl peptide - ENSP00000493019
NCBI entrez gene - 147     See in Manteia.
OMIM - 104220
RefSeq - NM_000679
RefSeq - XM_011534435
RefSeq Peptide - NP_000670
swissprot - A0A286YF88
swissprot - P35368
Ensembl - ENSG00000170214
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adra1baENSDARG00000011317Danio rerio
 adra1bbENSDARG00000041173Danio rerio
 ADRA1BENSGALG00000001416Gallus gallus
 Adra1bENSMUSG00000050541Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADRA1D / P25100 / adrenoceptor alpha 1DENSG0000017187350
ADRA1A / P35348 / adrenoceptor alpha 1AENSG0000012090744
HTR7 / P34969 / 5-hydroxytryptamine receptor 7ENSG0000014868025
ADRA2C / P18825 / adrenoceptor alpha 2CENSG0000018416024
ADRA2B / P18089 / adrenoceptor alpha 2BENSG0000027428624
HTR1A / P08908 / 5-hydroxytryptamine receptor 1AENSG0000017839424
HTR1D / P28221 / 5-hydroxytryptamine receptor 1DENSG0000017954623
HTR1F / P30939 / 5-hydroxytryptamine receptor 1FENSG0000017909723
ADRA2A / P08913 / adrenoceptor alpha 2AENSG0000015059422
HTR1B / P28222 / 5-hydroxytryptamine receptor 1BENSG0000013531222
HTR1E / P28566 / 5-hydroxytryptamine receptor 1EENSG0000016883021
HTR5A / P47898 / 5-hydroxytryptamine receptor 5AENSG0000015721919


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001115  Alpha 1B adrenoceptor
 IPR002233  Adrenoceptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IBA
 biological_processGO:0006937 regulation of muscle contraction IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IBA
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0019229 regulation of vasoconstriction IEA
 biological_processGO:0035556 intracellular signal transduction TAS
 biological_processGO:0042593 glucose homeostasis IBA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0045907 positive regulation of vasoconstriction IBA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IBA
 biological_processGO:0055117 regulation of cardiac muscle contraction IEA
 biological_processGO:0071875 adrenergic receptor signaling pathway IEA
 biological_processGO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004935 adrenergic receptor activity IEA
 molecular_functionGO:0004937 alpha1-adrenergic receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IDA


Pathways (from Reactome)
Pathway description
Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000146535 GNA12 / Q03113 / G protein subunit alpha 12  / reaction / complex
 ENSG00000186469 GNG2 / P59768 / G protein subunit gamma 2  / complex / reaction
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / complex / reaction
 ENSG00000120063 GNA13 / Q14344 / G protein subunit alpha 13  / complex / reaction






 

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