ENSG00000157219


Homo sapiens

Features
Gene ID: ENSG00000157219
  
Biological name :HTR5A
  
Synonyms : 5-hydroxytryptamine receptor 5A / HTR5A / P47898
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q36.2
Gene start: 155070324
Gene end: 155085749
  
Corresponding Affymetrix probe sets: 221362_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000287907
NCBI entrez gene - 3361     See in Manteia.
OMIM - 601305
RefSeq - NM_024012
RefSeq Peptide - NP_076917
swissprot - A4D2N2
swissprot - P47898
Ensembl - ENSG00000157219
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 htr5aaENSDARG00000038869Danio rerio
 htr5abENSDARG00000068557Danio rerio
 HTR5AENSGALG00000006362Gallus gallus
 Htr5aENSMUSG00000039106Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HTR1B / P28222 / 5-hydroxytryptamine receptor 1BENSG0000013531236
HTR1D / P28221 / 5-hydroxytryptamine receptor 1DENSG0000017954634
HTR1F / P30939 / 5-hydroxytryptamine receptor 1FENSG0000017909734
HTR1A / P08908 / 5-hydroxytryptamine receptor 1AENSG0000017839434
HTR1E / P28566 / 5-hydroxytryptamine receptor 1EENSG0000016883033
HTR7 / P34969 / 5-hydroxytryptamine receptor 7ENSG0000014868032
ADRA2C / P18825 / adrenoceptor alpha 2CENSG0000018416031
ADRA2A / P08913 / adrenoceptor alpha 2AENSG0000015059430
ADRA1A / P35348 / adrenoceptor alpha 1AENSG0000012090729
ADRA2B / P18089 / adrenoceptor alpha 2BENSG0000027428629
ADRA1B / P35368 / adrenoceptor alpha 1BENSG0000017021428
ADRA1D / P25100 / adrenoceptor alpha 1DENSG0000017187327


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001397  5-Hydroxytryptamine 5A receptor
 IPR002231  5-hydroxytryptamine receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA
 biological_processGO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0019933 cAMP-mediated signaling IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0098664 G-protein coupled serotonin receptor signaling pathway IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043204 perikaryon IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004993 G-protein coupled serotonin receptor activity IDA
 molecular_functionGO:0030594 neurotransmitter receptor activity IBA
 molecular_functionGO:0051378 serotonin binding IBA


Pathways (from Reactome)
Pathway description
Serotonin receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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