ENSMUSG00000024524


Mus musculus

Features
Gene ID: ENSMUSG00000024524
  
Biological name :Gnal
  
Synonyms : Gnal / guanine nucleotide binding protein, alpha stimulating, olfactory type / Q8CGK7
  
Possible biological names infered from orthology : G protein subunit alpha L / P38405
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E1
Gene start: 67088336
Gene end: 67226792
  
Corresponding Affymetrix probe sets: 10456363 (MoGene1.0st)   1439957_at (Mouse Genome 430 2.0 Array)   1442021_at (Mouse Genome 430 2.0 Array)   1446359_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025402
Ensembl peptide - ENSMUSP00000075908
NCBI entrez gene - 14680     See in Manteia.
MGI - MGI:95774
RefSeq - NM_177137
RefSeq - NM_010307
RefSeq Peptide - NP_034437
RefSeq Peptide - NP_796111
swissprot - Q66L47
swissprot - Q8CGK7
Ensembl - ENSMUSG00000024524
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01075509.1ENSDARG00000102797Danio rerio
 GNALENSGALG00000013785Gallus gallus
 GNALENSG00000141404Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gnas / Q9Z0F1 / P63094 / Q6R0H6 / Q6R0H7 / GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus / P84996* / Q5JWF2* / O95467* / P63092* / GNAS complex locus*ENSMUSG0000002752366


Protein motifs (from Interpro)
Interpro ID Name
 IPR000367  G-protein alpha subunit, group S
 IPR001019  Guanine nucleotide binding protein (G-protein), alpha subunit
 IPR011025  G protein alpha subunit, helical insertion
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001975 response to amphetamine IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007190 activation of adenylate cyclase activity IDA
 biological_processGO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway IGI
 biological_processGO:0007608 sensory perception of smell IMP
 biological_processGO:0031000 response to caffeine IMP
 cellular_componentGO:0005834 heterotrimeric G-protein complex ISA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IBA
 molecular_functionGO:0003924 GTPase activity IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019001 guanyl nucleotide binding IEA
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
Olfactory Signaling Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas

 MP:0001384 abnormal pup retrieval "a mother does not retrieve stray pups to the nest or delays retrieving stray pups" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
Show

Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas

 MP:0001984 abnormal olfaction "change in the ability to smell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas

 MP:0003462 abnormal response to novel odor "altered investigative behavior from controls in reactions associated with exposing an animal to a novel odor" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas

 MP:0009326 abnormal maternal crouching "females do not assume a position over young that facilitates suckling behavior" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000001 Gnai3 / Q9DC51 / guanine nucleotide binding protein (G protein), alpha inhibiting 3 / P08754* / G protein subunit alpha i3*  / complex / reaction
 ENSMUSG00000057614 Gnai1 / B2RSH2 / guanine nucleotide binding protein (G protein), alpha inhibiting 1 / P63096* / G protein subunit alpha i1*  / complex / reaction
 ENSMUSG00000032562 Gnai2 / P08752 / guanine nucleotide binding protein (G protein), alpha inhibiting 2 / P04899* / G protein subunit alpha i2*  / complex / reaction
 ENSMUSG00000028777 Gnat3 / Q3V3I2 / guanine nucleotide binding protein, alpha transducing 3 / A8MTJ3* / G protein subunit alpha transducin 3*  / complex / reaction
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / complex / reaction
 ENSMUSG00000029663 Gngt1 / Q61012 / guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 / P63211* / G protein subunit gamma transducin 1*  / reaction / complex






 

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