ENSMUSG00000029663


Mus musculus

Features
Gene ID: ENSMUSG00000029663
  
Biological name :Gngt1
  
Synonyms : Gngt1 / guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 / Q61012
  
Possible biological names infered from orthology : G protein subunit gamma transducin 1 / P63211
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: A1
Gene start: 3993792
Gene end: 3997436
  
Corresponding Affymetrix probe sets: 10536209 (MoGene1.0st)   1425167_a_at (Mouse Genome 430 2.0 Array)   1425168_at (Mouse Genome 430 2.0 Array)   1425219_x_at (Mouse Genome 430 2.0 Array)   1451633_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031673
NCBI entrez gene - 14699     See in Manteia.
MGI - MGI:109165
RefSeq - XM_017321389
RefSeq - NM_010314
RefSeq - XM_017321387
RefSeq - XM_017321388
RefSeq - XM_006504986
RefSeq Peptide - NP_034444
swissprot - Q61012
Ensembl - ENSMUSG00000029663
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gngt1ENSDARG00000035798Danio rerio
 GNGT1ENSG00000127928Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gng11 / P61953 / guanine nucleotide binding protein (G protein), gamma 11 / P61952* / G protein subunit gamma 11*ENSMUSG0000003276677
Gngt2 / Q61017 / guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 / O14610* / G protein subunit gamma transducin 2*ENSMUSG0000003881155


Protein motifs (from Interpro)
Interpro ID Name
 IPR001770  G-protein, gamma subunit
 IPR015898  G-protein gamma-like domain
 IPR036284  G-protein gamma-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007602 phototransduction IMP
 biological_processGO:0008104 protein localization IMP
 biological_processGO:0010659 cardiac muscle cell apoptotic process IEA
 biological_processGO:0042462 eye photoreceptor cell development IMP
 biological_processGO:0071456 cellular response to hypoxia IEA
 cellular_componentGO:0001750 photoreceptor outer segment IEA
 cellular_componentGO:0001917 photoreceptor inner segment IEA
 cellular_componentGO:0005834 heterotrimeric G-protein complex ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003924 GTPase activity ISO
 molecular_functionGO:0004871 obsolete signal transducer activity IEA


Pathways (from Reactome)
Pathway description
Activation of G protein gated Potassium channels
G-protein activation
Activation of the phototransduction cascade
Inactivation, recovery and regulation of the phototransduction cascade
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Olfactory Signaling Pathway
ADP signalling through P2Y purinoceptor 12
G beta:gamma signalling through PI3Kgamma
Prostacyclin signalling through prostacyclin receptor
Adrenaline,noradrenaline inhibits insulin secretion
Ca2+ pathway
G alpha (q) signalling events
G alpha (12/13) signalling events
G beta:gamma signalling through PLC beta
G alpha (s) signalling events
ADP signalling through P2Y purinoceptor 1
G alpha (i) signalling events
G alpha (z) signalling events
Glucagon-type ligand receptors
Thromboxane signalling through TP receptor
Vasopressin regulates renal water homeostasis via Aquaporins
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Cacna1atm1Kano/Cacna1atm1Kano,Grid2tm1(cre)Mwa/Grid2+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001999 photosensitivity "alterations in the response to sunlight or UV irradiation, especially sensitivity of the eyes" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Srftm1Rjs/Srftm2.1Nor,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Tg(APOA2)3Rub/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gngt1tm1Ogk/Gngt1tm1Ogk
Genetic Background: involves: 129

Allelic Composition: Gngt1tm1Ogk/Gngt1+
Genetic Background: involves: 129

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Tg(APOA2)3Rub/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gngt1tm1Ogk/Gngt1tm1Ogk
Genetic Background: involves: 129

Allelic Composition: Gngt1tm1Ogk/Gngt1+
Genetic Background: involves: 129

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Tg(APOA2)3Rub/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gnat1tm1Clma/Gnat1tm1Clma,Gngt1tm1Dgen/Gngt1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Gngt1tm1Dgen/Gngt1tm1Dgen,Pdctm1Vya/Pdctm1Vya
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0008451 retinal rod cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Tg(APOA2)3Rub/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008518 retinal outer nuclear layer degeneration "a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Gngt1tm1Ogk/Gngt1tm1Ogk
Genetic Background: involves: 129

 MP:0008587 short photoreceptor outer segment "decreased length of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Tg(APOA2)3Rub/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034837 Gnat1 / P20612 / guanine nucleotide binding protein, alpha transducing 1 / P11488* / G protein subunit alpha transducin 1*  / complex
 ENSMUSG00000015994 Fnta / Q61239 / Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha / P49354* / farnesyltransferase, CAAX box, alpha*  / reaction
 ENSMUSG00000024524 Gnal / Q8CGK7 / guanine nucleotide binding protein, alpha stimulating, olfactory type / P38405* / G protein subunit alpha L*  / reaction / complex
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / complex / reaction
 ENSMUSG00000033373 Fntb / Q8K2I1 / Protein farnesyltransferase subunit beta / P49356* / farnesyltransferase, CAAX box, beta*  / reaction






 

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