ENSMUSG00000015994


Mus musculus

Features
Gene ID: ENSMUSG00000015994
  
Biological name :Fnta
  
Synonyms : Fnta / Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha / Q61239
  
Possible biological names infered from orthology : farnesyltransferase, CAAX box, alpha / P49354
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A2
Gene start: 25998722
Gene end: 26015650
  
Corresponding Affymetrix probe sets: 10577910 (MoGene1.0st)   1417465_at (Mouse Genome 430 2.0 Array)   1447904_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000016138
NCBI entrez gene - 14272     See in Manteia.
MGI - MGI:104683
RefSeq - NM_008033
RefSeq Peptide - NP_032059
swissprot - Q541Z2
swissprot - Q61239
Ensembl - ENSMUSG00000015994
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fntaENSDARG00000099143Danio rerio
 FNTAENSGALG00000015397Gallus gallus
 FNTAENSG00000168522Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002088  Protein prenyltransferase, alpha subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007528 neuromuscular junction development IMP
 biological_processGO:0018342 protein prenylation IEA
 biological_processGO:0018343 protein farnesylation ISO
 biological_processGO:0018344 protein geranylgeranylation ISO
 biological_processGO:0045213 neurotransmitter receptor metabolic process IMP
 biological_processGO:0071340 skeletal muscle acetylcholine-gated channel clustering IDA
 biological_processGO:0090044 positive regulation of tubulin deacetylation ISO
 biological_processGO:0090045 positive regulation of deacetylase activity ISO
 biological_processGO:0099601 regulation of neurotransmitter receptor activity IEA
 cellular_componentGO:0005875 microtubule associated complex IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005953 CAAX-protein geranylgeranyltransferase complex ISO
 cellular_componentGO:0005965 protein farnesyltransferase complex ISO
 molecular_functionGO:0004659 prenyltransferase activity IEA
 molecular_functionGO:0004660 protein farnesyltransferase activity IDA
 molecular_functionGO:0004661 protein geranylgeranyltransferase activity ISO
 molecular_functionGO:0004662 CAAX-protein geranylgeranyltransferase activity IEA
 molecular_functionGO:0004663 Rab geranylgeranyltransferase activity IDA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008318 protein prenyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030548 acetylcholine receptor regulator activity IMP
 molecular_functionGO:0030971 receptor tyrosine kinase binding IPI
 molecular_functionGO:0043014 alpha-tubulin binding IEA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
Inactivation, recovery and regulation of the phototransduction cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000033373 Fntb / Q8K2I1 / Protein farnesyltransferase subunit beta / P49356* / farnesyltransferase, CAAX box, beta*  / complex
 ENSMUSG00000029663 Gngt1 / Q61012 / guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 / P63211* / G protein subunit gamma transducin 1*  / reaction
 ENSMUSG00000031628 Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr