ENSG00000168522


Homo sapiens

Features
Gene ID: ENSG00000168522
  
Biological name :FNTA
  
Synonyms : farnesyltransferase, CAAX box, alpha / FNTA / P49354
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p11.21
Gene start: 43034194
Gene end: 43085788
  
Corresponding Affymetrix probe sets: 200090_at (Human Genome U133 Plus 2.0 Array)   209471_s_at (Human Genome U133 Plus 2.0 Array)   230808_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432411
Ensembl peptide - ENSP00000432892
Ensembl peptide - ENSP00000473479
Ensembl peptide - ENSP00000437208
Ensembl peptide - ENSP00000436998
Ensembl peptide - ENSP00000435455
Ensembl peptide - ENSP00000434430
Ensembl peptide - ENSP00000303423
NCBI entrez gene - 2339     See in Manteia.
OMIM - 134635
RefSeq - NM_002027
RefSeq Peptide - NP_002018
swissprot - E9PN85
swissprot - E9PK84
swissprot - B3KVN2
swissprot - H0YCW1
swissprot - E9PQP6
swissprot - P49354
swissprot - E9PPM9
Ensembl - ENSG00000168522
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fntaENSDARG00000099143Danio rerio
 FNTAENSGALG00000015397Gallus gallus
 FntaENSMUSG00000015994Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002088  Protein prenyltransferase, alpha subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0007528 neuromuscular junction development IEA
 biological_processGO:0018342 protein prenylation IEA
 biological_processGO:0018343 protein farnesylation TAS
 biological_processGO:0018344 protein geranylgeranylation TAS
 biological_processGO:0022400 regulation of rhodopsin mediated signaling pathway TAS
 biological_processGO:0045213 neurotransmitter receptor metabolic process IEA
 biological_processGO:0071340 skeletal muscle acetylcholine-gated channel clustering IEA
 biological_processGO:0090044 positive regulation of tubulin deacetylation IDA
 biological_processGO:0090045 positive regulation of deacetylase activity IDA
 biological_processGO:0097194 execution phase of apoptosis TAS
 biological_processGO:0099601 regulation of neurotransmitter receptor activity IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005875 microtubule associated complex IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005953 CAAX-protein geranylgeranyltransferase complex IDA
 cellular_componentGO:0005965 protein farnesyltransferase complex IDA
 molecular_functionGO:0004659 prenyltransferase activity IEA
 molecular_functionGO:0004660 protein farnesyltransferase activity TAS
 molecular_functionGO:0004661 protein geranylgeranyltransferase activity TAS
 molecular_functionGO:0004662 CAAX-protein geranylgeranyltransferase activity IEA
 molecular_functionGO:0004663 Rab geranylgeranyltransferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0008318 protein prenyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030548 acetylcholine receptor regulator activity IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0043014 alpha-tubulin binding IDA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
Inactivation, recovery and regulation of the phototransduction cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000257365 FNTB / P49356 / farnesyltransferase, CAAX box, beta  / complex
 ENSG00000164305 CASP3 / P42574 / caspase 3  / reaction
 ENSG00000127928 GNGT1 / P63211 / G protein subunit gamma transducin 1  / reaction






 

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