ENSG00000257365


Homo sapiens

Features
Gene ID: ENSG00000257365
  
Biological name :FNTB
  
Synonyms : farnesyltransferase, CAAX box, beta / FNTB / P49356
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q23.3
Gene start: 64986720
Gene end: 65062652
  
Corresponding Affymetrix probe sets: 1568865_at (Human Genome U133 Plus 2.0 Array)   1773_at (Human Genome U133 Plus 2.0 Array)   204764_at (Human Genome U133 Plus 2.0 Array)   225851_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000246166
NCBI entrez gene - 100529261     See in Manteia.
NCBI entrez gene - 2342     See in Manteia.
OMIM - 134636
RefSeq - NM_001202558
RefSeq - NM_002028
RefSeq Peptide - NP_001189487
RefSeq Peptide - NP_002019
swissprot - P49356
Ensembl - ENSG00000257365
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fntbENSDARG00000027916Danio rerio
 ENSGALG00000038143Gallus gallus
 FntbENSMUSG00000033373Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CHURC1-FNTB / CHURC1-FNTB readthroughENSG0000012595490


Protein motifs (from Interpro)
Interpro ID Name
 IPR001330  PFTB repeat
 IPR008930  Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
 IPR026872  Protein farnesyltransferase subunit beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010035 response to inorganic substance IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0018343 protein farnesylation IDA
 biological_processGO:0022400 regulation of rhodopsin mediated signaling pathway TAS
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0045787 positive regulation of cell cycle IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0051770 positive regulation of nitric-oxide synthase biosynthetic process IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005875 microtubule associated complex IDA
 cellular_componentGO:0005965 protein farnesyltransferase complex IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004311 farnesyltranstransferase activity IEA
 molecular_functionGO:0004659 prenyltransferase activity IEA
 molecular_functionGO:0004660 protein farnesyltransferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019840 isoprenoid binding IEA
 molecular_functionGO:0042277 peptide binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Inactivation, recovery and regulation of the phototransduction cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000127928 GNGT1 / P63211 / G protein subunit gamma transducin 1  / reaction
 ENSG00000168522 FNTA / P49354 / farnesyltransferase, CAAX box, alpha  / complex






 

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