ENSG00000127928


Homo sapiens

Features
Gene ID: ENSG00000127928
  
Biological name :GNGT1
  
Synonyms : GNGT1 / G protein subunit gamma transducin 1 / P63211
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q21.3
Gene start: 93591573
Gene end: 93911265
  
Corresponding Affymetrix probe sets: 207166_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000395857
Ensembl peptide - ENSP00000401781
Ensembl peptide - ENSP00000248572
Ensembl peptide - ENSP00000388777
Ensembl peptide - ENSP00000395756
NCBI entrez gene - 2792     See in Manteia.
OMIM - 189970
RefSeq - XM_017012009
RefSeq - NM_001329426
RefSeq - NM_021955
RefSeq Peptide - NP_001316355
RefSeq Peptide - NP_068774
swissprot - P63211
swissprot - C9JGI9
Ensembl - ENSG00000127928
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gngt1ENSDARG00000035798Danio rerio
 Gngt1ENSMUSG00000029663Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GNG11 / P61952 / G protein subunit gamma 11ENSG0000012792076
GNGT2 / O14610 / G protein subunit gamma transducin 2ENSG0000016708358


Protein motifs (from Interpro)
Interpro ID Name
 IPR001770  G-protein, gamma subunit
 IPR015898  G-protein gamma-like domain
 IPR036284  G-protein gamma-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007602 phototransduction IEA
 biological_processGO:0008104 protein localization IEA
 biological_processGO:0010659 cardiac muscle cell apoptotic process IEA
 biological_processGO:0016056 rhodopsin mediated signaling pathway TAS
 biological_processGO:0022400 regulation of rhodopsin mediated signaling pathway TAS
 biological_processGO:0042462 eye photoreceptor cell development IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 cellular_componentGO:0001750 photoreceptor outer segment IEA
 cellular_componentGO:0001917 photoreceptor inner segment IEA
 cellular_componentGO:0005834 heterotrimeric G-protein complex IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0097381 photoreceptor disc membrane TAS
 molecular_functionGO:0003924 GTPase activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Activation of G protein gated Potassium channels
G-protein activation
Activation of the phototransduction cascade
Inactivation, recovery and regulation of the phototransduction cascade
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Olfactory Signaling Pathway
ADP signalling through P2Y purinoceptor 12
G beta:gamma signalling through PI3Kgamma
Prostacyclin signalling through prostacyclin receptor
Adrenaline,noradrenaline inhibits insulin secretion
Ca2+ pathway
G alpha (q) signalling events
G alpha (12/13) signalling events
G beta:gamma signalling through PLC beta
G alpha (s) signalling events
ADP signalling through P2Y purinoceptor 1
G alpha (i) signalling events
G alpha (z) signalling events
Glucagon-type ligand receptors
Thromboxane signalling through TP receptor
Vasopressin regulates renal water homeostasis via Aquaporins
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000114349 GNAT1 / P11488 / G protein subunit alpha transducin 1  / reaction / complex
 ENSG00000257365 FNTB / P49356 / farnesyltransferase, CAAX box, beta  / reaction
 ENSG00000141404 GNAL / P38405 / G protein subunit alpha L  / complex / reaction
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / complex / reaction
 ENSG00000163914 RHO / P08100 / rhodopsin  / reaction
 ENSG00000168522 FNTA / P49354 / farnesyltransferase, CAAX box, alpha  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr