ENSMUSG00000036353


Mus musculus

Features
Gene ID: ENSMUSG00000036353
  
Biological name :P2ry12
  
Synonyms : P2ry12 / purinergic receptor P2Y, G-protein coupled 12 / Q9CPV9
  
Possible biological names infered from orthology : purinergic receptor P2Y12 / Q9H244
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: D
Gene start: 59216272
Gene end: 59262871
  
Corresponding Affymetrix probe sets: 10498371 (MoGene1.0st)   1431724_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126819
Ensembl peptide - ENSMUSP00000143521
Ensembl peptide - ENSMUSP00000143706
Ensembl peptide - ENSMUSP00000051353
Ensembl peptide - ENSMUSP00000143036
NCBI entrez gene - 70839     See in Manteia.
MGI - MGI:1918089
RefSeq - XM_006502085
RefSeq - NM_001357007
RefSeq - NM_001357008
RefSeq - NM_001357010
RefSeq - NM_027571
RefSeq - XM_006502083
RefSeq - XM_006502084
RefSeq Peptide - NP_081847
RefSeq Peptide - NP_001343936
RefSeq Peptide - NP_001343937
RefSeq Peptide - NP_001343939
swissprot - Q9CPV9
swissprot - Q546L4
swissprot - A0A0G2JGU7
Ensembl - ENSMUSG00000036353
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p2ry12ENSDARG00000069945Danio rerio
 P2RY12ENSGALG00000036470Gallus gallus
 P2RY12ENSG00000169313Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P2ry13 / Q9D8I2 / P2Y purinoceptor 13 / Q9BPV8* / purinergic receptor P2Y13*ENSMUSG0000003636243
P2ry14 / Q9ESG6 / purinergic receptor P2Y, G-protein coupled, 14 / Q15391* / purinergic receptor P2Y14*ENSMUSG0000003638139
Gpr87 / Q99MT7 / G-protein coupled receptor 87 / Q9BY21*ENSMUSG0000005143137
Gpr171 / Q8BG55 / G protein-coupled receptor 171 / O14626*ENSMUSG0000005007531
Gpr34 / Q9R1K6 / Probable G-protein coupled receptor 34 / Q9UPC5* / G protein-coupled receptor 34*ENSMUSG0000004022926
Gpr82 / Q8BZR0 / Probable G-protein coupled receptor 82 / Q96P67* / G protein-coupled receptor 82*ENSMUSG0000004767820


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR005394  P2Y12 purinoceptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001973 adenosine receptor signaling pathway IEA
 biological_processGO:0006930 substrate-dependent cell migration, cell extension IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IMP
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0008347 glial cell migration IEA
 biological_processGO:0010700 negative regulation of norepinephrine secretion IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030168 platelet activation IMP
 biological_processGO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA
 biological_processGO:0043270 positive regulation of ion transport IGI
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0051924 regulation of calcium ion transport IEA
 biological_processGO:0070527 platelet aggregation ISS
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0071318 cellular response to ATP IMP
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:1904139 regulation of microglial cell migration IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009925 basal plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031224 intrinsic component of membrane ISS
 molecular_functionGO:0001609 G-protein coupled adenosine receptor activity IMP
 molecular_functionGO:0001621 ADP receptor activity ISO
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA


Pathways (from Reactome)
Pathway description
ADP signalling through P2Y purinoceptor 12
P2Y receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr1d2tm1Dgen/Nr1d2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1dtm2Ais/Hist1h1d+,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1dtm2Ais/Hist1h1d+,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1dtm2Ais/Hist1h1d+,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: P2ry12tm1Cjf/P2ry12tm1Cjf
Genetic Background: involves: 129/Sv

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1dtm2Ais/Hist1h1d+,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: P2ry12tm1Cjf/P2ry12tm1Cjf
Genetic Background: involves: 129/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000001 Gnai3 / Q9DC51 / guanine nucleotide binding protein (G protein), alpha inhibiting 3 / P08754* / G protein subunit alpha i3*  / complex / reaction
 ENSMUSG00000057614 Gnai1 / B2RSH2 / guanine nucleotide binding protein (G protein), alpha inhibiting 1 / P63096* / G protein subunit alpha i1*  / reaction / complex
 ENSMUSG00000028777 Gnat3 / Q3V3I2 / guanine nucleotide binding protein, alpha transducing 3 / A8MTJ3* / G protein subunit alpha transducin 3*  / reaction / complex
 ENSMUSG00000032562 Gnai2 / P08752 / guanine nucleotide binding protein (G protein), alpha inhibiting 2 / P04899* / G protein subunit alpha i2*  / reaction / complex
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / complex / reaction
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / reaction / complex






 

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