ENSMUSG00000036362


Mus musculus

Features
Gene ID: ENSMUSG00000036362
  
Biological name :P2ry13
  
Synonyms : P2ry13 / P2Y purinoceptor 13 / Q9D8I2
  
Possible biological names infered from orthology : purinergic receptor P2Y13 / Q9BPV8
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: D
Gene start: 59207892
Gene end: 59210882
  
Corresponding Affymetrix probe sets: 10498367 (MoGene1.0st)   1428700_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044730
NCBI entrez gene - 74191     See in Manteia.
MGI - MGI:1921441
RefSeq - NM_028808
RefSeq Peptide - NP_083084
swissprot - Q9D8I2
Ensembl - ENSMUSG00000036362
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p2ry13ENSDARG00000069944Danio rerio
 P2RY13ENSGALG00000039432Gallus gallus
 P2RY13ENSG00000181631Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P2ry12 / Q9CPV9 / purinergic receptor P2Y, G-protein coupled 12 / Q9H244* / purinergic receptor P2Y12*ENSMUSG0000003635344
P2ry14 / Q9ESG6 / purinergic receptor P2Y, G-protein coupled, 14 / Q15391* / purinergic receptor P2Y14*ENSMUSG0000003638138
Gpr87 / Q99MT7 / G-protein coupled receptor 87 / Q9BY21*ENSMUSG0000005143137
Gpr171 / Q8BG55 / G protein-coupled receptor 171 / O14626*ENSMUSG0000005007531
Gpr34 / Q9R1K6 / Probable G-protein coupled receptor 34 / Q9UPC5* / G protein-coupled receptor 34*ENSMUSG0000004022924
Gpr82 / Q8BZR0 / Probable G-protein coupled receptor 82 / Q96P67* / G protein-coupled receptor 82*ENSMUSG0000004767818


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR008109  P2Y13 purinoceptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007194 negative regulation of adenylate cyclase activity IEA
 biological_processGO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0045028 G-protein coupled purinergic nucleotide receptor activity IBA


Pathways (from Reactome)
Pathway description
P2Y receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr1h2tm1.1Nph/Nr1h2tm1.1Nph
Genetic Background: B6.129-Nr1h2tm1.1Nph

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr1h2tm1.1Nph/Nr1h2tm1.1Nph
Genetic Background: B6.129-Nr1h2tm1.1Nph

 MP:0003191 abnormal cellular cholesterol metabolism "impaired regulation of cellular cholesterol levels" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt,Tg(GZMB-Tax)#Lera/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003442 decreased circulating glycerol level "lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nr1h2tm1.1Nph/Nr1h2tm1.1Nph
Genetic Background: B6.129-Nr1h2tm1.1Nph

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nr1h2tm1.1Nph/Nr1h2tm1.1Nph
Genetic Background: B6.129-Nr1h2tm1.1Nph

 MP:0004772 abnormal bile secretion "any anomaly in the quantity or rate of bile secreted through the bile ducts in a given length of time" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt,Tg(GZMB-Tax)#Lera/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nr1h2tm1.1Nph/Nr1h2tm1.1Nph
Genetic Background: B6.129-Nr1h2tm1.1Nph

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nr1h2tm1.1Nph/Nr1h2tm1.1Nph
Genetic Background: B6.129-Nr1h2tm1.1Nph

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Nr1h2tm1.1Nph/Nr1h2tm1.1Nph
Genetic Background: B6.129-Nr1h2tm1.1Nph

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt,Tg(GZMB-Tax)#Lera/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010026 decreased liver cholesterol level "less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt,Tg(GZMB-Tax)#Lera/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010080 abnormal hepatocyte physiology "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt,Tg(GZMB-Tax)#Lera/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010967 increased compact bone area "increase in the total amount of cross-sectional area of compact bone tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1h2tm1.1Nph/Nr1h2tm1.1Nph
Genetic Background: B6.129-Nr1h2tm1.1Nph

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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