ENSGALG00000015608


Gallus gallus

Features
Gene ID: ENSGALG00000015608
  
Biological name :ADRA2C
  
Synonyms : ADRA2C / adrenoceptor alpha 2C
  
Possible biological names infered from orthology : Alpha-2C adrenergic receptor / P18825 / Q01337
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 82152617
Gene end: 82153957
  
Corresponding Affymetrix probe sets: GgaAffx.9949.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000025121
NCBI entrez gene - 428799     See in Manteia.
RefSeq - XM_004936302
swissprot - F1NDD8
Ensembl - ENSGALG00000015608
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adra2cENSDARG00000069669Danio rerio
 ADRA2CENSG00000184160Homo sapiens
 Adra2cENSMUSG00000045318Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADRA2A / adrenoceptor alpha 2A / P08913*ENSGALG0000002352152
ENSGALG0000003545739
ADRA1B / adrenoceptor alpha 1B / P35368*ENSGALG0000000141627
HTR1B / 5-hydroxytryptamine receptor 1B / P28222* / P28334* / 5-hydroxytryptamine (serotonin) receptor 1B*ENSGALG0000001589527
HTR1D / 5-hydroxytryptamine receptor 1D / P28221* / Q61224* / 5-hydroxytryptamine (serotonin) receptor 1D*ENSGALG0000000082027
ADRA1D* / P25100* / adrenoceptor alpha 1D*ENSGALG0000003878727
HTR7 / 5-hydroxytryptamine receptor 7 / P32304* / P34969* / 5-hydroxytryptamine (serotonin) receptor 7*ENSGALG0000004054925
HTR7LENSGALG0000003508125
HTR1A / 5-hydroxytryptamine receptor 1A / P08908* / Q64264* / 5-hydroxytryptamine (serotonin) receptor 1A*ENSGALG0000001474225
HTR1F / 5-hydroxytryptamine receptor 1F / P30939* / Q02284* / 5-hydroxytryptamine (serotonin) receptor 1F*ENSGALG0000001549424
ADRA1A / adrenoceptor alpha 1A / P35348* / P97718* / Alpha-1A adrenergic receptor *ENSGALG0000000046924
HTR1E / 5-hydroxytryptamine receptor 1E / P28566*ENSGALG0000001582623
HTR5A / 5-hydroxytryptamine receptor 5A / P30966* / P47898* / 5-hydroxytryptamine (serotonin) receptor 5A*ENSGALG0000000636222


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000735  Alpha 2C adrenoceptor
 IPR002233  Adrenoceptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006940 regulation of smooth muscle contraction IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0019229 regulation of vasoconstriction IEA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0032148 activation of protein kinase B activity IEA
 biological_processGO:0035625 obsolete epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0071875 adrenergic receptor signaling pathway IEA
 biological_processGO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004935 adrenergic receptor activity IBA
 molecular_functionGO:0004938 alpha2-adrenergic receptor activity IEA
 molecular_functionGO:0031694 alpha-2A adrenergic receptor binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0051379 epinephrine binding IEA


Pathways (from Reactome)
Pathway description
Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001334 GNB1 / G protein subunit beta 1 / P62873* / P62874* / guanine nucleotide binding protein (G protein), beta 1*  / reaction / complex
 ENSGALG00000006719 GNAZ / G protein subunit alpha z / O70443* / P19086* / guanine nucleotide binding protein, alpha z subunit*  / complex / reaction
 ENSGALG00000027629 GNG2 / G protein subunit gamma 2 / P59768* / P63213* / guanine nucleotide binding protein (G protein), gamma 2*  / complex / reaction






 

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