ENSDARG00000069669


Danio rerio

Features
Gene ID: ENSDARG00000069669
  
Biological name :adra2c
  
Synonyms : adra2c / adrenoceptor alpha 2C / Q90WY6
  
Possible biological names infered from orthology : Alpha-2C adrenergic receptor / P18825 / Q01337
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 40992682
Gene end: 40994259
  
Corresponding Affymetrix probe sets: DrAffx.2.33.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000101388
swissprot - B3DJZ9
swissprot - Q90WY6
ZFIN ID - ZDB-GENE-021010-3
Ensembl - ENSDARG00000069669
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ADRA2CENSGALG00000015608Gallus gallus
 ADRA2CENSG00000184160Homo sapiens
 Adra2cENSMUSG00000045318Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
adra2b / adrenoceptor alpha 2B / P18089*ENSDARG0000010209653
adra2db / adrenergic, alpha-2D-, receptor bENSDARG0000005466751
adra2da / adrenergic, alpha-2D-, receptor aENSDARG0000009127751
adra2a / adrenoceptor alpha 2A / P08913*ENSDARG0000004084150
FP236542.1 / ADRA2B* / P18089* / adrenoceptor alpha 2B*ENSDARG0000011698848
htr1fa / 5-hydroxytryptamine (serotonin) receptor 1Fa / HTR1F* / Q02284* / P30939* / 5-hydroxytryptamine receptor 1F* / 5-hydroxytryptamine (serotonin) receptor 1F*ENSDARG0000010986228
htr1d / 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled / P28221* / Q61224* / 5-hydroxytryptamine receptor 1D* / 5-hydroxytryptamine (serotonin) receptor 1D*ENSDARG0000005412428
htr1b / 5-hydroxytryptamine (serotonin) receptor 1B / P28222* / P28334* / 5-hydroxytryptamine receptor 1B*ENSDARG0000005398727
htr1aa / 5-hydroxytryptamine (serotonin) receptor 1A a / HTR1A* / Q64264* / P08908* / 5-hydroxytryptamine receptor 1A* / 5-hydroxytryptamine (serotonin) receptor 1A*ENSDARG0000009374527
adra1bb / adrenoceptor alpha 1Bb / ADRA1B* / P35368* / adrenoceptor alpha 1B*ENSDARG0000004117327
adra1d / adrenoceptor alpha 1D / P25100*ENSDARG0000002410127
htr1fb / 5-hydroxytryptamine (serotonin) receptor 1Fb / HTR1F* / Q02284* / P30939* / 5-hydroxytryptamine receptor 1F* / 5-hydroxytryptamine (serotonin) receptor 1F*ENSDARG0000005358027
htr1ab / 5-hydroxytryptamine (serotonin) receptor 1A bENSDARG0000005709827
adra1ba / adrenoceptor alpha 1Ba / ADRA1B* / P35368* / adrenoceptor alpha 1B*ENSDARG0000001131726
htr7b / 5-hydroxytryptamine (serotonin) receptor 7bENSDARG0000002758726
htr7c / 5-hydroxytryptamine (serotonin) receptor 7cENSDARG0000009527226
htr7a / 5-hydroxytryptamine (serotonin) receptor 7a / HTR7* / P34969* / P32304* / 5-hydroxytryptamine receptor 7* / 5-hydroxytryptamine (serotonin) receptor 7*ENSDARG0000005694926
adra1aa / adrenoceptor alpha 1Aa / ADRA1A* / P35348* / adrenoceptor alpha 1A*ENSDARG0000002872525
htr5aa / 5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate a / HTR5A* / P47898* / P30966* / 5-hydroxytryptamine receptor 5A* / 5-hydroxytryptamine (serotonin) receptor 5A*ENSDARG0000003886925
adra1ab / adrenoceptor alpha 1Ab / ADRA1A* / P35348* / P97718* / adrenoceptor alpha 1A* / Alpha-1A adrenergic receptor *ENSDARG0000002763825


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000735  Alpha 2C adrenoceptor
 IPR002233  Adrenoceptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006940 regulation of smooth muscle contraction IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0019229 regulation of vasoconstriction IEA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0071875 adrenergic receptor signaling pathway IEA
 biological_processGO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway IBA
 biological_processGO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004935 adrenergic receptor activity IEA
 molecular_functionGO:0004938 alpha2-adrenergic receptor activity ISS


Pathways (from Reactome)
Pathway description
Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000056831 gng2 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / P63213* / G protein subunit gamma 2*  / reaction / complex
 ENSDARG00000099844 GNAZ / G protein subunit alpha z / P19086*  / complex / reaction
 ENSDARG00000090454 gnb1a / Q6PH57 / guanine nucleotide binding protein (G protein), beta polypeptide 1a / GNB1* / P62873* / G protein subunit beta 1*  / complex / reaction
 ENSDARG00000104372 gnb1b / guanine nucleotide binding protein (G protein), beta polypeptide 1b / GNB1* / P62874* / P62873* / G protein subunit beta 1* / guanine nucleotide binding protein (G protein), beta 1*  / complex / reaction






 

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