ENSG00000169860


Homo sapiens

Features
Gene ID: ENSG00000169860
  
Biological name :P2RY1
  
Synonyms : P2RY1 / P47900 / purinergic receptor P2Y1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q25.2
Gene start: 152834693
Gene end: 152841439
  
Corresponding Affymetrix probe sets: 207455_at (Human Genome U133 Plus 2.0 Array)   231925_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000304767
NCBI entrez gene - 5028     See in Manteia.
OMIM - 601167
RefSeq - NM_002563
RefSeq Peptide - NP_002554
swissprot - P47900
Ensembl - ENSG00000169860
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p2ry1ENSDARG00000105281Danio rerio
 P2RY1ENSGALG00000010357Gallus gallus
 P2ry1ENSMUSG00000027765Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P2RY4 / P51582 / pyrimidinergic receptor P2Y4ENSG0000018691236
P2RY2 / P41231 / purinergic receptor P2Y2ENSG0000017559133
OXGR1 / Q96P68 / oxoglutarate receptor 1ENSG0000016562129
Q9BXA5 / SUCNR1 / succinate receptor 1ENSG0000019882929
P2RY6 / Q15077 / pyrimidinergic receptor P2Y6ENSG0000017163129
PPAN-P2RY11 / PPAN-P2RY11 readthroughENSG0000024320728
GPR17 / Q13304 / G protein-coupled receptor 17ENSG0000014423027
P2RY11 / Q96G91 / purinergic receptor P2Y11ENSG0000024416527
Q9Y271 / CYSLTR1 / cysteinyl leukotriene receptor 1ENSG0000017319825
Q9NS75 / CYSLTR2 / cysteinyl leukotriene receptor 2ENSG0000015220724
LPAR6 / P43657 / lysophosphatidic acid receptor 6ENSG0000013967924
GPR183 / P32249 / G protein-coupled receptor 183ENSG0000016950824
LPAR4 / Q99677 / lysophosphatidic acid receptor 4ENSG0000014714524
O00398 / P2RY10 / P2Y receptor family member 10ENSG0000007858923
GPR174 / Q9BXC1 / G protein-coupled receptor 174ENSG0000014713823
PTAFR / P25105 / platelet activating factor receptorENSG0000016940322
LPAR5 / Q9H1C0 / lysophosphatidic acid receptor 5ENSG0000018457422


Protein motifs (from Interpro)
Interpro ID Name
 IPR000142  P2Y purinoceptor 1
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001973 adenosine receptor signaling pathway IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0008347 glial cell migration IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010700 negative regulation of norepinephrine secretion IEA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0023019 signal transduction involved in regulation of gene expression IEA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0032962 positive regulation of inositol trisphosphate biosynthetic process IEA
 biological_processGO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0043270 positive regulation of ion transport IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046887 positive regulation of hormone secretion IEA
 biological_processGO:0051100 negative regulation of binding IEA
 biological_processGO:0060406 positive regulation of penile erection IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070848 response to growth factor IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0090075 relaxation of muscle IEA
 biological_processGO:0097746 regulation of blood vessel diameter IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009986 cell surface HDA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0031686 A1 adenosine receptor binding IEA
 molecular_functionGO:0043531 ADP binding IEA
 molecular_functionGO:0045028 G-protein coupled purinergic nucleotide receptor activity ISS
 molecular_functionGO:0045031 ATP-activated adenosine receptor activity IEA
 molecular_functionGO:0045032 ADP-activated adenosine receptor activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
P2Y receptors
ADP signalling through P2Y purinoceptor 1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000088256 GNA11 / P29992 / G protein subunit alpha 11  / reaction / complex
 ENSG00000060558 GNA15 / P30679 / G protein subunit alpha 15  / reaction / complex
 ENSG00000156052 GNAQ / P50148 / G protein subunit alpha q  / reaction / complex
 ENSG00000186469 GNG2 / P59768 / G protein subunit gamma 2  / complex / reaction
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / complex / reaction
 ENSG00000156049 GNA14 / O95837 / G protein subunit alpha 14  / complex / reaction






 

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