ENSG00000152207


Homo sapiens

Features
Gene ID: ENSG00000152207
  
Biological name :CYSLTR2
  
Synonyms : CYSLTR2 / cysteinyl leukotriene receptor 2 / Q9NS75
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q14.2
Gene start: 48653711
Gene end: 48711226
  
Corresponding Affymetrix probe sets: 220813_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000282018
Ensembl peptide - ENSP00000479446
Ensembl peptide - ENSP00000482031
Ensembl peptide - ENSP00000482041
Ensembl peptide - ENSP00000477930
NCBI entrez gene - 57105     See in Manteia.
OMIM - 605666
RefSeq - NM_001308471
RefSeq - NM_001308465
RefSeq - NM_001308467
RefSeq - NM_001308468
RefSeq - NM_001308469
RefSeq - NM_001308470
RefSeq - NM_001308476
RefSeq - NM_020377
RefSeq Peptide - NP_065110
RefSeq Peptide - NP_001295394
RefSeq Peptide - NP_001295396
RefSeq Peptide - NP_001295397
RefSeq Peptide - NP_001295398
RefSeq Peptide - NP_001295399
RefSeq Peptide - NP_001295400
RefSeq Peptide - NP_001295405
swissprot - Q5KU17
swissprot - A0A1B0GXM0
swissprot - Q9NS75
Ensembl - ENSG00000152207
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q920A1ENSMUSG00000033470Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Y271 / CYSLTR1 / cysteinyl leukotriene receptor 1ENSG0000017319833
GPR17 / Q13304 / G protein-coupled receptor 17ENSG0000014423030
LPAR4 / Q99677 / lysophosphatidic acid receptor 4ENSG0000014714528
GPR183 / P32249 / G protein-coupled receptor 183ENSG0000016950828
OXGR1 / Q96P68 / oxoglutarate receptor 1ENSG0000016562127
LPAR5 / Q9H1C0 / lysophosphatidic acid receptor 5ENSG0000018457427
LPAR6 / P43657 / lysophosphatidic acid receptor 6ENSG0000013967927
P2RY2 / P41231 / purinergic receptor P2Y2ENSG0000017559127
Q9BXA5 / SUCNR1 / succinate receptor 1ENSG0000019882926
P2RY1 / P47900 / purinergic receptor P2Y1ENSG0000016986025
P2RY6 / Q15077 / pyrimidinergic receptor P2Y6ENSG0000017163125
PTAFR / P25105 / platelet activating factor receptorENSG0000016940324
GPR174 / Q9BXC1 / G protein-coupled receptor 174ENSG0000014713824
P2RY4 / P51582 / pyrimidinergic receptor P2Y4ENSG0000018691223
O00398 / P2RY10 / P2Y receptor family member 10ENSG0000007858922
P2RY11 / Q96G91 / purinergic receptor P2Y11ENSG0000024416521
PPAN-P2RY11 / PPAN-P2RY11 readthroughENSG0000024320720


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR004071  Cysteinyl leukotriene receptor
 IPR013311  Cysteinyl leukotriene receptor 2
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response NAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007218 neuropeptide signaling pathway IBA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0061737 leukotriene signaling pathway IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001631 cysteinyl leukotriene receptor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004974 leukotriene receptor activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008528 G-protein coupled peptide receptor activity IBA


Pathways (from Reactome)
Pathway description
Leukotriene receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000539 Abnormality of refraction 
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 HP:0000541 Detached retina 
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 HP:0000572 Visual loss 
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 HP:0007902 Vitreous hemorrhage 
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 HP:0007906 Increased intraocular pressure 
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 HP:0008494 Inferior lens subluxation 
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 HP:0010920 Zonular cataract "Zonular cataracts are defined to be cataracts that affect specific regions of the lens." [HPO:probinson, HPO:vkumar, pmid:18035564]
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 HP:0011499 Mydriasis "Abnormal dilatation of the iris." [DDD:ncarter]
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 HP:0011524 Iris melanoma "Malignant tumor of melanocytes affecting the iris." [DDD:ncarter]
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 HP:0012054 Choroidal melanoma "Malignant tumor of melanocytes of the choroid. The classic appearance of choroidal melanoma is a pigmented dome-shaped or collar button-shaped tumor with an associated exudative retinal detachment. Choroidal melanoma is usually pigmented, but can be variably pigmented and even amelanotic (non-pigmented)." [HPO:probinson, pmid:22557869]
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 HP:0012055 Ciliary body melanoma "Malignant tumor of melanocytes of the ciliary body." [HPO:probinson]
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 HP:0012508 Metamorphopsia "A visual anomaly in which images appear distorted. A grid of straight lines appears wavy and parts of the grid may appear blank." [HPO:probinson]
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 HP:0030786 Photopsia "Perceived flashes of light." [HPO:probinson, PMID:10506812]
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 HP:0030800 Abnormal visual accommodation "An anomaly in the process of visual accommodation, which is the process of adjustment of the eye to enable sharp vision of objects at different distances. Accommodation is mediated by contraction of the ciliary muscles, which alter the convexity of the lens and, consequently, its refractive power." [HPO:probinson]
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 HP:0100533 Inflammatory abnormality of the eye "Inflammation of the eye, parts of the eye or the periorbital region." [HPO:sdoelken]
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 HP:0200026 ocular pain 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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