ENSG00000169403


Homo sapiens

Features
Gene ID: ENSG00000169403
  
Biological name :PTAFR
  
Synonyms : P25105 / platelet activating factor receptor / PTAFR
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p35.3
Gene start: 28147166
Gene end: 28193936
  
Corresponding Affymetrix probe sets: 206278_at (Human Genome U133 Plus 2.0 Array)   211661_x_at (Human Genome U133 Plus 2.0 Array)   227184_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000301974
Ensembl peptide - ENSP00000362965
Ensembl peptide - ENSP00000442658
NCBI entrez gene - 5724     See in Manteia.
OMIM - 173393
RefSeq - NM_001164722
RefSeq - NM_000952
RefSeq - NM_001164721
RefSeq - NM_001164723
RefSeq Peptide - NP_000943
RefSeq Peptide - NP_001158193
RefSeq Peptide - NP_001158194
RefSeq Peptide - NP_001158195
swissprot - P25105
Ensembl - ENSG00000169403
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptafrENSDARG00000042370Danio rerio
 PTAFRENSGALG00000000783Gallus gallus
 PtafrENSMUSG00000056529Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LPAR4 / Q99677 / lysophosphatidic acid receptor 4ENSG0000014714528
P2RY2 / P41231 / purinergic receptor P2Y2ENSG0000017559126
GPR174 / Q9BXC1 / G protein-coupled receptor 174ENSG0000014713825
LPAR6 / P43657 / lysophosphatidic acid receptor 6ENSG0000013967925
O00398 / P2RY10 / P2Y receptor family member 10ENSG0000007858925
Q9NS75 / CYSLTR2 / cysteinyl leukotriene receptor 2ENSG0000015220724
P2RY1 / P47900 / purinergic receptor P2Y1ENSG0000016986024
Q9Y271 / CYSLTR1 / cysteinyl leukotriene receptor 1ENSG0000017319824
GPR17 / Q13304 / G protein-coupled receptor 17ENSG0000014423024
P2RY4 / P51582 / pyrimidinergic receptor P2Y4ENSG0000018691224
Q9BXA5 / SUCNR1 / succinate receptor 1ENSG0000019882923
GPR183 / P32249 / G protein-coupled receptor 183ENSG0000016950823
LPAR5 / Q9H1C0 / lysophosphatidic acid receptor 5ENSG0000018457421
P2RY6 / Q15077 / pyrimidinergic receptor P2Y6ENSG0000017163120
OXGR1 / Q96P68 / oxoglutarate receptor 1ENSG0000016562119
PPAN-P2RY11 / PPAN-P2RY11 readthroughENSG0000024320717
P2RY11 / Q96G91 / purinergic receptor P2Y11ENSG0000024416517


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR002282  Platelet-activating factor receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001816 cytokine production IEA
 biological_processGO:0002693 positive regulation of cellular extravasation IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007567 parturition IEA
 biological_processGO:0009609 response to symbiotic bacterium IEA
 biological_processGO:0010863 positive regulation of phospholipase C activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0032959 inositol trisphosphate biosynthetic process IEA
 biological_processGO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043315 positive regulation of neutrophil degranulation IEA
 biological_processGO:0045056 transcytosis IEA
 biological_processGO:0045410 positive regulation of interleukin-6 biosynthetic process IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045776 negative regulation of blood pressure IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IEA
 biological_processGO:0046683 response to organophosphorus IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IDA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0060732 positive regulation of inositol phosphate biosynthetic process IEA
 biological_processGO:0071258 cellular response to gravity IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071398 cellular response to fatty acid IEA
 biological_processGO:0071548 response to dexamethasone IEA
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 biological_processGO:1902943 positive regulation of voltage-gated chloride channel activity IEA
 biological_processGO:1903039 positive regulation of leukocyte cell-cell adhesion IEA
 biological_processGO:1903238 positive regulation of leukocyte tethering or rolling IEA
 biological_processGO:1904058 positive regulation of sensory perception of pain IEA
 biological_processGO:1904300 positive regulation of transcytosis IEA
 biological_processGO:1904303 positive regulation of maternal process involved in parturition IEA
 biological_processGO:1904306 positive regulation of gastro-intestinal system smooth muscle contraction IEA
 biological_processGO:1904316 response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine IEA
 biological_processGO:1904317 cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0070821 tertiary granule membrane TAS
 molecular_functionGO:0001530 lipopolysaccharide binding IEA
 molecular_functionGO:0001875 lipopolysaccharide receptor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0004992 platelet activating factor receptor activity IDA
 molecular_functionGO:0005543 phospholipid binding IDA
 molecular_functionGO:0045028 G-protein coupled purinergic nucleotide receptor activity IBA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IEA


Pathways (from Reactome)
Pathway description
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interleukin-10 signaling
Neutrophil degranulation
Interferon gamma signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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