Manteia

ENSMUSG00000056529

Mus musculus

Features

Gene ID:	ENSMUSG00000056529

Biological name :	Ptafr

Synonyms :	Platelet-activating factor receptor / Ptafr / Q62035

Possible biological names infered from orthology :	P25105

Species:	Mus musculus

Chr. number:	4
Strand:	1
Band:	D2.3
Gene start:	132564067
Gene end:	132582683

Corresponding Affymetrix probe sets:	10508734 (MoGene1.0st) 1427871_at (Mouse Genome 430 2.0 Array) 1427872_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000070925 NCBI entrez gene - 19204 See in Manteia. MGI - MGI:106066 RefSeq - NM_001081211 RefSeq Peptide - NP_001074680 swissprot - Q62035 Ensembl - ENSMUSG00000056529

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ptafr	ENSDARG00000042370	Danio rerio
PTAFR	ENSGALG00000000783	Gallus gallus
PTAFR	ENSG00000169403	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Lpar4 / Q8BLG2 / Lysophosphatidic acid receptor 4 / Q99677*	ENSMUSG00000049929	29
P2ry10 / Q8BFU7 / Mus musculus purinergic receptor P2Y, G-protein coupled 10 (P2ry10), transcript variant 2, mRNA. / O00398* / P2Y receptor family member 10*	ENSMUSG00000050921	26
Lpar6 / Q8BMC0 / Lysophosphatidic acid receptor 6 / P43657*	ENSMUSG00000033446	25
P2ry10b / purinergic receptor P2Y, G-protein coupled 10B	ENSMUSG00000054293	25
P2ry2 / purinergic receptor P2Y2 / P41231*	ENSMUSG00000032860	25
P2ry1 / P49650 / purinergic receptor P2Y, G-protein coupled 1 / P47900* / purinergic receptor P2Y1*	ENSMUSG00000027765	25
Q99JA4 / Cysltr1 / Cysteinyl leukotriene receptor 1 / Q9Y271*	ENSMUSG00000052821	24
Gpr183 / Q3U6B2 / G protein-coupled receptor 183 / P32249*	ENSMUSG00000051212	24
Gpr17 / Q6NS65 / Uracil nucleotide/cysteinyl leukotriene receptor / Q13304* / G protein-coupled receptor 17*	ENSMUSG00000052229	23
Gpr174 / Q3U507 / G protein-coupled receptor 174 / Q9BXC1*	ENSMUSG00000073008	23
P2ry4 / Q9JJS7 / P2Y purinoceptor 4 / P51582* / pyrimidinergic receptor P2Y4*	ENSMUSG00000044359	23
Lpar5 / lysophosphatidic acid receptor 5 / Q9H1C0*	ENSMUSG00000067714	23
Q920A1 / Cysltr2 / Cysteinyl leukotriene receptor 2 / Q9NS75*	ENSMUSG00000033470	22
Oxgr1 / Q6IYF8 / 2-oxoglutarate receptor 1 / Q96P68* / oxoglutarate receptor 1*	ENSMUSG00000044819	19
Q99MT6 / Sucnr1 / Succinate receptor 1 / Q9BXA5*	ENSMUSG00000027762	19
P2ry6 / Q9ERK9 / P2Y purinoceptor 6 / Q15077* / pyrimidinergic receptor P2Y6*	ENSMUSG00000048779	19

Protein motifs (from Interpro)

Interpro ID	Name
IPR000276	G protein-coupled receptor, rhodopsin-like
IPR002282	Platelet-activating factor receptor
IPR017452	GPCR, rhodopsin-like, 7TM

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001816	cytokine production	IMP
biological_process	GO:0002693	positive regulation of cellular extravasation	IEA
biological_process	GO:0006357	regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0006935	chemotaxis	IEA
biological_process	GO:0006954	inflammatory response	IMP
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	ISO
biological_process	GO:0007567	parturition	IEA
biological_process	GO:0009609	response to symbiotic bacterium	IEA
biological_process	GO:0010863	positive regulation of phospholipase C activity	IEA
biological_process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IEA
biological_process	GO:0032496	response to lipopolysaccharide	IEA
biological_process	GO:0032760	positive regulation of tumor necrosis factor production	IEA
biological_process	GO:0032959	inositol trisphosphate biosynthetic process	IMP
biological_process	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway	IEA
biological_process	GO:0043315	positive regulation of neutrophil degranulation	IEA
biological_process	GO:0045056	transcytosis	IEA
biological_process	GO:0045410	positive regulation of interleukin-6 biosynthetic process	IEA
biological_process	GO:0045727	positive regulation of translation	IEA
biological_process	GO:0045776	negative regulation of blood pressure	IEA
biological_process	GO:0045907	positive regulation of vasoconstriction	IEA
biological_process	GO:0045987	positive regulation of smooth muscle contraction	IEA
biological_process	GO:0046683	response to organophosphorus	IEA
biological_process	GO:0048015	phosphatidylinositol-mediated signaling	IEA
biological_process	GO:0048661	positive regulation of smooth muscle cell proliferation	IEA
biological_process	GO:0060732	positive regulation of inositol phosphate biosynthetic process	IEA
biological_process	GO:0071258	cellular response to gravity	IEA
biological_process	GO:0071320	cellular response to cAMP	IEA
biological_process	GO:0071398	cellular response to fatty acid	IEA
biological_process	GO:0071548	response to dexamethasone	IEA
biological_process	GO:0097755	positive regulation of blood vessel diameter	IEA
biological_process	GO:1902943	positive regulation of voltage-gated chloride channel activity	IEA
biological_process	GO:1903039	positive regulation of leukocyte cell-cell adhesion	IEA
biological_process	GO:1903238	positive regulation of leukocyte tethering or rolling	IEA
biological_process	GO:1904058	positive regulation of sensory perception of pain	IEA
biological_process	GO:1904300	positive regulation of transcytosis	IEA
biological_process	GO:1904303	positive regulation of maternal process involved in parturition	IEA
biological_process	GO:1904306	positive regulation of gastro-intestinal system smooth muscle contraction	IEA
biological_process	GO:1904316	response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine	IEA
biological_process	GO:1904317	cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine	IEA
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005887	integral component of plasma membrane	IBA
cellular_component	GO:0016020	membrane	ISO
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0001530	lipopolysaccharide binding	IMP
molecular_function	GO:0001875	lipopolysaccharide receptor activity	IMP
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0004930	G-protein coupled receptor activity	IEA
molecular_function	GO:0004992	platelet activating factor receptor activity	ISO
molecular_function	GO:0005543	phospholipid binding	IEA
molecular_function	GO:0045028	G-protein coupled purinergic nucleotide receptor activity	IBA
molecular_function	GO:0051019	mitogen-activated protein kinase binding	IEA

Pathways (from Reactome)

Pathway description

Class A/1 (Rhodopsin-like receptors)

G alpha (q) signalling events

Neutrophil degranulation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001876	decreased inflammatory response	"less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0002411	decreased susceptibility to bacterial infection	"reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Twist1^tm1Bhr/Twist1⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129/Sv * 129X1/SvJ
MP:0004003	abnormal vascular endothelial cell physiology	"anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cat^f/Cat^f Genetic Background: Not Specified
MP:0005027	increased susceptibility to parasitic infection	"greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0005167	abnormal blood-brain barrier	"anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cat^f/Cat^f Genetic Background: Not Specified
MP:0005596	increased susceptibility to type I hypersensitvity reaction	"greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr