ENSMUSG00000073008


Mus musculus

Features
Gene ID: ENSMUSG00000073008
  
Biological name :Gpr174
  
Synonyms : Gpr174 / G protein-coupled receptor 174 / Q3U507
  
Possible biological names infered from orthology : Q9BXC1
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: D
Gene start: 107255878
Gene end: 107296769
  
Corresponding Affymetrix probe sets: 10601424 (MoGene1.0st)   1440900_at (Mouse Genome 430 2.0 Array)   1447792_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113032
Ensembl peptide - ENSMUSP00000112808
Ensembl peptide - ENSMUSP00000112974
Ensembl peptide - ENSMUSP00000098852
Ensembl peptide - ENSMUSP00000137372
NCBI entrez gene - 213439     See in Manteia.
MGI - MGI:2685222
RefSeq - XM_017318457
RefSeq - NM_001033251
RefSeq - NM_001177781
RefSeq - NM_001177782
RefSeq - NM_001358747
RefSeq - XM_006527932
RefSeq Peptide - NP_001171253
RefSeq Peptide - NP_001345676
RefSeq Peptide - NP_001028423
RefSeq Peptide - NP_001171252
swissprot - Q3U507
Ensembl - ENSMUSG00000073008
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpr174ENSDARG00000079826Danio rerio
 GPR174ENSGALG00000004111Gallus gallus
 GPR174ENSG00000147138Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P2ry10b / purinergic receptor P2Y, G-protein coupled 10BENSMUSG0000005429346
P2ry10 / Q8BFU7 / Mus musculus purinergic receptor P2Y, G-protein coupled 10 (P2ry10), transcript variant 2, mRNA. / O00398* / P2Y receptor family member 10*ENSMUSG0000005092143
Lpar4 / Q8BLG2 / Lysophosphatidic acid receptor 4 / Q99677*ENSMUSG0000004992932
Lpar6 / Q8BMC0 / Lysophosphatidic acid receptor 6 / P43657*ENSMUSG0000003344629
Lpar5 / lysophosphatidic acid receptor 5 / Q9H1C0*ENSMUSG0000006771428
Gpr17 / Q6NS65 / Uracil nucleotide/cysteinyl leukotriene receptor / Q13304* / G protein-coupled receptor 17*ENSMUSG0000005222927
P2ry4 / Q9JJS7 / P2Y purinoceptor 4 / P51582* / pyrimidinergic receptor P2Y4*ENSMUSG0000004435927
P2ry6 / Q9ERK9 / P2Y purinoceptor 6 / Q15077* / pyrimidinergic receptor P2Y6*ENSMUSG0000004877927
P2ry2 / purinergic receptor P2Y2 / P41231*ENSMUSG0000003286027
Q920A1 / Cysltr2 / Cysteinyl leukotriene receptor 2 / Q9NS75*ENSMUSG0000003347026
P2ry1 / P49650 / purinergic receptor P2Y, G-protein coupled 1 / P47900* / purinergic receptor P2Y1*ENSMUSG0000002776526
Q99JA4 / Cysltr1 / Cysteinyl leukotriene receptor 1 / Q9Y271*ENSMUSG0000005282125
Gpr183 / Q3U6B2 / G protein-coupled receptor 183 / P32249*ENSMUSG0000005121225
Ptafr / Q62035 / Platelet-activating factor receptor / P25105*ENSMUSG0000005652924
Oxgr1 / Q6IYF8 / 2-oxoglutarate receptor 1 / Q96P68* / oxoglutarate receptor 1*ENSMUSG0000004481923
Q99MT6 / Sucnr1 / Succinate receptor 1 / Q9BXA5*ENSMUSG0000002776220


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0043029 T cell homeostasis IMP
 cellular_componentGO:0005886 plasma membrane IC
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0045125 bioactive lipid receptor activity IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wfs1tm1Yoka/Wfs1tm1Yoka
Genetic Background: B6J.129-Wfs1tm1Yoka

Allelic Composition: Gpr174tm1Cys/Gpr174+
Genetic Background: B6.129-Gpr174tm1Cys

Allelic Composition: Foxp3tm3(DTR/GFP)Ayr/Foxp3+,Gpr174tm1Cys/Gpr174+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wfs1tm1Yoka/Wfs1tm1Yoka
Genetic Background: B6J.129-Wfs1tm1Yoka

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Wfs1tm1Yoka/Wfs1tm1Yoka
Genetic Background: B6J.129-Wfs1tm1Yoka

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wfs1tm1Yoka/Wfs1tm1Yoka
Genetic Background: B6J.129-Wfs1tm1Yoka

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wfs1tm1Yoka/Wfs1tm1Yoka
Genetic Background: B6J.129-Wfs1tm1Yoka

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr