ENSMUSG00000051212


Mus musculus

Features
Gene ID: ENSMUSG00000051212
  
Biological name :Gpr183
  
Synonyms : Gpr183 / G protein-coupled receptor 183 / Q3U6B2
  
Possible biological names infered from orthology : P32249
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: E5
Gene start: 121952551
Gene end: 121965195
  
Corresponding Affymetrix probe sets: 10422496 (MoGene1.0st)   1437356_at (Mouse Genome 430 2.0 Array)   1457691_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000052404
Ensembl peptide - ENSMUSP00000154545
NCBI entrez gene - 321019     See in Manteia.
MGI - MGI:2442034
RefSeq - NM_183031
RefSeq Peptide - NP_898852
swissprot - Q3U6B2
Ensembl - ENSMUSG00000051212
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 B0UXR0ENSDARG00000074302Danio rerio
 gpr183aENSDARG00000010317Danio rerio
 GPR183ENSGALG00000016881Gallus gallus
 GPR183ENSG00000169508Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P2ry2 / purinergic receptor P2Y2 / P41231*ENSMUSG0000003286026
Gpr17 / Q6NS65 / Uracil nucleotide/cysteinyl leukotriene receptor / Q13304* / G protein-coupled receptor 17*ENSMUSG0000005222925
Lpar4 / Q8BLG2 / Lysophosphatidic acid receptor 4 / Q99677*ENSMUSG0000004992925
Lpar5 / lysophosphatidic acid receptor 5 / Q9H1C0*ENSMUSG0000006771425
Q920A1 / Cysltr2 / Cysteinyl leukotriene receptor 2 / Q9NS75*ENSMUSG0000003347025
P2ry1 / P49650 / purinergic receptor P2Y, G-protein coupled 1 / P47900* / purinergic receptor P2Y1*ENSMUSG0000002776525
Q99JA4 / Cysltr1 / Cysteinyl leukotriene receptor 1 / Q9Y271*ENSMUSG0000005282124
Lpar6 / Q8BMC0 / Lysophosphatidic acid receptor 6 / P43657*ENSMUSG0000003344624
P2ry10b / purinergic receptor P2Y, G-protein coupled 10BENSMUSG0000005429324
Gpr174 / Q3U507 / G protein-coupled receptor 174 / Q9BXC1*ENSMUSG0000007300824
P2ry4 / Q9JJS7 / P2Y purinoceptor 4 / P51582* / pyrimidinergic receptor P2Y4*ENSMUSG0000004435924
Q99MT6 / Sucnr1 / Succinate receptor 1 / Q9BXA5*ENSMUSG0000002776223
Ptafr / Q62035 / Platelet-activating factor receptor / P25105*ENSMUSG0000005652923
P2ry10 / Q8BFU7 / Mus musculus purinergic receptor P2Y, G-protein coupled 10 (P2ry10), transcript variant 2, mRNA. / O00398* / P2Y receptor family member 10*ENSMUSG0000005092123
P2ry6 / Q9ERK9 / P2Y purinoceptor 6 / Q15077* / pyrimidinergic receptor P2Y6*ENSMUSG0000004877921
Oxgr1 / Q6IYF8 / 2-oxoglutarate receptor 1 / Q96P68* / oxoglutarate receptor 1*ENSMUSG0000004481920


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IMP
 biological_processGO:0002313 mature B cell differentiation involved in immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002407 dendritic cell chemotaxis IMP
 biological_processGO:0006959 humoral immune response IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0010818 T cell chemotaxis IMP
 biological_processGO:0030316 osteoclast differentiation IMP
 biological_processGO:0030595 leukocyte chemotaxis IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0036145 dendritic cell homeostasis IMP
 biological_processGO:0060326 cell chemotaxis IMP
 biological_processGO:0061470 T follicular helper cell differentiation IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:2000458 regulation of astrocyte chemotaxis IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity ISO
 molecular_functionGO:0008142 oxysterol binding IEA


Pathways (from Reactome)
Pathway description
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpr183tm1.2Rbr/Gpr183tm1.2Rbr,Ightm1Rbr/Ightm1Rbr,Tg(IgkHyHEL10)1Rbr/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ikbkgtm1.1Chtr/Y,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

Allelic Composition: Gpr183tm1.2Rbr/Gpr183tm1.2Rbr,Ightm1Rbr/Ightm1Rbr,Tg(IgkHyHEL10)1Rbr/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpr183tm1.2Rbr/Gpr183tm1.2Rbr,Ightm1Rbr/Ightm1Rbr,Tg(IgkHyHEL10)1Rbr/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0005153 abnormal B cell proliferation "change from the norm in the ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gpr183tm1.2Rbr/Gpr183tm1.2Rbr,Ightm1Rbr/Ightm1Rbr,Tg(IgkHyHEL10)1Rbr/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ikbkgtm1.1Chtr/Y,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

Allelic Composition: Gpr183tm1.2Rbr/Gpr183tm1.2Rbr,Ightm1Rbr/Ightm1Rbr,Tg(IgkHyHEL10)1Rbr/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0008122 decreased myeloid dendritic cell number "reduction in the number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses" [PMID:10449155, PMID:9521319]
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Allelic Composition: Secisbp2tm1d(EUCOMM)Wtsi/Secisbp2tm1d(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0008124 decreased plasmacytoid dendritic cell number "reduced number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]
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Allelic Composition: Secisbp2tm1d(EUCOMM)Wtsi/Secisbp2tm1d(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0008191 abnormal follicular B cell physiology "abnormal function of a resting mature B cell with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpr183tm1.2Rbr/Gpr183tm1.2Rbr,Ightm1Rbr/Ightm1Rbr,Tg(IgkHyHEL10)1Rbr/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0008550 abnormal circulating interferon-beta level "anomaly in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
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Allelic Composition: Secisbp2tm1d(EUCOMM)Wtsi/Secisbp2tm1d(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0008573 increased circulating interferon-alpha level "increase in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Secisbp2tm1d(EUCOMM)Wtsi/Secisbp2tm1d(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Secisbp2tm1d(EUCOMM)Wtsi/Secisbp2tm1d(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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