ENSMUSG00000048779


Mus musculus

Features
Gene ID: ENSMUSG00000048779
  
Biological name :P2ry6
  
Synonyms : P2ry6 / P2Y purinoceptor 6 / Q9ERK9
  
Possible biological names infered from orthology : pyrimidinergic receptor P2Y6 / Q15077
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E2
Gene start: 100937630
Gene end: 100974649
  
Corresponding Affymetrix probe sets: 10565958 (MoGene1.0st)   1425214_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000055697
NCBI entrez gene - 233571     See in Manteia.
MGI - MGI:2673874
RefSeq - XM_011241739
RefSeq - NM_183168
RefSeq - XM_006507640
RefSeq Peptide - NP_898991
swissprot - Q9ERK9
swissprot - Q3UQ86
Ensembl - ENSMUSG00000048779
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-6n21.13ENSDARG00000069459Danio rerio
 P2RY6ENSGALG00000017327Gallus gallus
 P2RY6ENSG00000171631Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P2ry2 / purinergic receptor P2Y2 / P41231*ENSMUSG0000003286039
P2ry4 / Q9JJS7 / P2Y purinoceptor 4 / P51582* / pyrimidinergic receptor P2Y4*ENSMUSG0000004435938
P2ry1 / P49650 / purinergic receptor P2Y, G-protein coupled 1 / P47900* / purinergic receptor P2Y1*ENSMUSG0000002776532
Oxgr1 / Q6IYF8 / 2-oxoglutarate receptor 1 / Q96P68* / oxoglutarate receptor 1*ENSMUSG0000004481931
Lpar4 / Q8BLG2 / Lysophosphatidic acid receptor 4 / Q99677*ENSMUSG0000004992929
Gpr17 / Q6NS65 / Uracil nucleotide/cysteinyl leukotriene receptor / Q13304* / G protein-coupled receptor 17*ENSMUSG0000005222929
Lpar5 / lysophosphatidic acid receptor 5 / Q9H1C0*ENSMUSG0000006771428
Q99MT6 / Sucnr1 / Succinate receptor 1 / Q9BXA5*ENSMUSG0000002776227
Lpar6 / Q8BMC0 / Lysophosphatidic acid receptor 6 / P43657*ENSMUSG0000003344627
Gpr174 / Q3U507 / G protein-coupled receptor 174 / Q9BXC1*ENSMUSG0000007300827
Q99JA4 / Cysltr1 / Cysteinyl leukotriene receptor 1 / Q9Y271*ENSMUSG0000005282126
P2ry10 / Q8BFU7 / Mus musculus purinergic receptor P2Y, G-protein coupled 10 (P2ry10), transcript variant 2, mRNA. / O00398* / P2Y receptor family member 10*ENSMUSG0000005092126
Q920A1 / Cysltr2 / Cysteinyl leukotriene receptor 2 / Q9NS75*ENSMUSG0000003347026
P2ry10b / purinergic receptor P2Y, G-protein coupled 10BENSMUSG0000005429325
Gpr183 / Q3U6B2 / G protein-coupled receptor 183 / P32249*ENSMUSG0000005121223
Ptafr / Q62035 / Platelet-activating factor receptor / P25105*ENSMUSG0000005652920


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001973  P2Y6 purinoceptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0030321 transepithelial chloride transport IDA
 biological_processGO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA
 biological_processGO:0071380 cellular response to prostaglandin E stimulus IDA
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0019103 pyrimidine nucleotide binding IC
 molecular_functionGO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA
 molecular_functionGO:0045029 UDP-activated nucleotide receptor activity IDA


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
P2Y receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac

Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte P2ry6tm1Jabo

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Slc14a1tm1Ask/Slc14a1tm1Ask,Slc14a2tm1Bxy/Slc14a2tm1Bxy
Genetic Background: involves: C57BL/6J

Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte P2ry6tm1Jabo

 MP:0002281 abnormal respiratory mucosa goblet cell morphology "structural anomaly of the cells of the respiratory epithelial lining that produce and secrete mucins" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc14a1tm1Ask/Slc14a1tm1Ask,Slc14a2tm1Bxy/Slc14a2tm1Bxy
Genetic Background: involves: C57BL/6J

Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte P2ry6tm1Jabo

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnao1tm4Lbi/Gnao1tm4Lbi,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac

 MP:0003026 decreased vascular smooth muscle contraction "reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Gnao1tm4Lbi/Gnao1tm4Lbi,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac

Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte P2ry6tm1Jabo

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac

 MP:0005591 decreased vasodilation "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gnao1tm4Lbi/Gnao1tm4Lbi,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0006414 decreased T cell apoptosis "decrease in the number of T cells undergoing programmed cell death" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac

Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte P2ry6tm1Jabo

 MP:0008672 increased interleukin-13 secretion "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
Show

Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac

Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte P2ry6tm1Jabo

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac

Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte P2ry6tm1Jabo

 MP:0008702 increased interleukin-5 secretion "increase in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
Show

Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac

Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte P2ry6tm1Jabo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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