ENSMUSG00000052821


Mus musculus

Features
Gene ID: ENSMUSG00000052821
  
Biological name :Cysltr1
  
Synonyms : Cysltr1 / Cysteinyl leukotriene receptor 1 / Q99JA4
  
Possible biological names infered from orthology : Q9Y271
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: D
Gene start: 106574346
Gene end: 106603679
  
Corresponding Affymetrix probe sets: 10606355 (MoGene1.0st)   1418944_at (Mouse Genome 430 2.0 Array)   1449282_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000063520
Ensembl peptide - ENSMUSP00000109108
NCBI entrez gene - 58861     See in Manteia.
MGI - MGI:1926218
RefSeq - NM_001281859
RefSeq - NM_021476
RefSeq Peptide - NP_001268788
RefSeq Peptide - NP_067451
swissprot - Q99JA4
Ensembl - ENSMUSG00000052821
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cysltr1ENSDARG00000058246Danio rerio
 CYSLTR1ENSGALG00000004128Gallus gallus
 Q9Y271ENSG00000173198Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q920A1 / Cysltr2 / Cysteinyl leukotriene receptor 2 / Q9NS75*ENSMUSG0000003347032
P2ry1 / P49650 / purinergic receptor P2Y, G-protein coupled 1 / P47900* / purinergic receptor P2Y1*ENSMUSG0000002776528
Lpar4 / Q8BLG2 / Lysophosphatidic acid receptor 4 / Q99677*ENSMUSG0000004992928
Lpar6 / Q8BMC0 / Lysophosphatidic acid receptor 6 / P43657*ENSMUSG0000003344628
Gpr17 / Q6NS65 / Uracil nucleotide/cysteinyl leukotriene receptor / Q13304* / G protein-coupled receptor 17*ENSMUSG0000005222927
Oxgr1 / Q6IYF8 / 2-oxoglutarate receptor 1 / Q96P68* / oxoglutarate receptor 1*ENSMUSG0000004481925
P2ry2 / purinergic receptor P2Y2 / P41231*ENSMUSG0000003286025
P2ry10b / purinergic receptor P2Y, G-protein coupled 10BENSMUSG0000005429325
Lpar5 / lysophosphatidic acid receptor 5 / Q9H1C0*ENSMUSG0000006771424
Gpr174 / Q3U507 / G protein-coupled receptor 174 / Q9BXC1*ENSMUSG0000007300824
P2ry6 / Q9ERK9 / P2Y purinoceptor 6 / Q15077* / pyrimidinergic receptor P2Y6*ENSMUSG0000004877924
Ptafr / Q62035 / Platelet-activating factor receptor / P25105*ENSMUSG0000005652924
P2ry10 / Q8BFU7 / Mus musculus purinergic receptor P2Y, G-protein coupled 10 (P2ry10), transcript variant 2, mRNA. / O00398* / P2Y receptor family member 10*ENSMUSG0000005092124
Gpr183 / Q3U6B2 / G protein-coupled receptor 183 / P32249*ENSMUSG0000005121224
P2ry4 / Q9JJS7 / P2Y purinoceptor 4 / P51582* / pyrimidinergic receptor P2Y4*ENSMUSG0000004435923
Q99MT6 / Sucnr1 / Succinate receptor 1 / Q9BXA5*ENSMUSG0000002776221


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR004071  Cysteinyl leukotriene receptor
 IPR013310  Cysteinyl leukotriene receptor 1
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002437 inflammatory response to antigenic stimulus IMP
 biological_processGO:0003013 circulatory system process IBA
 biological_processGO:0006816 calcium ion transport IDA
 biological_processGO:0006935 chemotaxis IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IDA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007218 neuropeptide signaling pathway IBA
 biological_processGO:0061737 leukotriene signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004974 leukotriene receptor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008528 G-protein coupled peptide receptor activity IBA


Pathways (from Reactome)
Pathway description
Leukotriene receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ubr4tm1.2Nkt/Ubr4tm1.2Nkt,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

Allelic Composition: Cysltr1tm1Ykn/Cysltr1tm1Ykn,Cysltr2tm1Ykn/Cysltr2tm1Ykn,Oxgr1tm1(KOMP)Vlcg/Oxgr1tm1(KOMP)Vlcg
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NTac

 MP:0002405 respiratory system inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Itgb4tm1Fgg/Itgb4tm1Fgg
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003071 decreased vascular permeability "reduced or slower ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Itgb4tm1Fgg/Itgb4tm1Fgg
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb4tm1Fgg/Itgb4tm1Fgg
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgb4tm1Fgg/Itgb4tm1Fgg
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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