ENSMUSG00000032860


Mus musculus

Features
Gene ID: ENSMUSG00000032860
  
Biological name :P2ry2
  
Synonyms : P2ry2 / purinergic receptor P2Y2
  
Possible biological names infered from orthology : P41231
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E2
Gene start: 100996568
Gene end: 101012866
  
Corresponding Affymetrix probe sets: 10565962 (MoGene1.0st)   1450318_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146352
Ensembl peptide - ENSMUSP00000146923
Ensembl peptide - ENSMUSP00000146679
Ensembl peptide - ENSMUSP00000036765
Ensembl peptide - ENSMUSP00000137152
NCBI entrez gene - 18442     See in Manteia.
MGI - MGI:105107
RefSeq - NM_001302347
RefSeq - NM_008773
RefSeq - NM_001302346
RefSeq Peptide - NP_032799
RefSeq Peptide - NP_001289275
RefSeq Peptide - NP_001289276
swissprot - A0A0R4J289
swissprot - A0A140LIR2
Ensembl - ENSMUSG00000032860
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p2ry2.1ENSDARG00000099915Danio rerio
 p2ry2.2ENSDARG00000104927Danio rerio
 p2ry2.3ENSDARG00000104425Danio rerio
 P2RY2ENSGALG00000042317Gallus gallus
 P2RY2ENSG00000175591Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P2ry4 / Q9JJS7 / P2Y purinoceptor 4 / P51582* / pyrimidinergic receptor P2Y4*ENSMUSG0000004435949
P2ry6 / Q9ERK9 / P2Y purinoceptor 6 / Q15077* / pyrimidinergic receptor P2Y6*ENSMUSG0000004877934
P2ry1 / P49650 / purinergic receptor P2Y, G-protein coupled 1 / P47900* / purinergic receptor P2Y1*ENSMUSG0000002776532
Lpar6 / Q8BMC0 / Lysophosphatidic acid receptor 6 / P43657*ENSMUSG0000003344627
Oxgr1 / Q6IYF8 / 2-oxoglutarate receptor 1 / Q96P68* / oxoglutarate receptor 1*ENSMUSG0000004481927
Gpr17 / Q6NS65 / Uracil nucleotide/cysteinyl leukotriene receptor / Q13304* / G protein-coupled receptor 17*ENSMUSG0000005222926
Lpar4 / Q8BLG2 / Lysophosphatidic acid receptor 4 / Q99677*ENSMUSG0000004992926
Q99MT6 / Sucnr1 / Succinate receptor 1 / Q9BXA5*ENSMUSG0000002776225
Lpar5 / lysophosphatidic acid receptor 5 / Q9H1C0*ENSMUSG0000006771425
Gpr183 / Q3U6B2 / G protein-coupled receptor 183 / P32249*ENSMUSG0000005121225
Q920A1 / Cysltr2 / Cysteinyl leukotriene receptor 2 / Q9NS75*ENSMUSG0000003347025
Gpr174 / Q3U507 / G protein-coupled receptor 174 / Q9BXC1*ENSMUSG0000007300825
Q99JA4 / Cysltr1 / Cysteinyl leukotriene receptor 1 / Q9Y271*ENSMUSG0000005282124
P2ry10b / purinergic receptor P2Y, G-protein coupled 10BENSMUSG0000005429323
Ptafr / Q62035 / Platelet-activating factor receptor / P25105*ENSMUSG0000005652923
P2ry10 / Q8BFU7 / Mus musculus purinergic receptor P2Y, G-protein coupled 10 (P2ry10), transcript variant 2, mRNA. / O00398* / P2Y receptor family member 10*ENSMUSG0000005092122


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000356  P2Y2 purinoceptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA
 biological_processGO:0070257 positive regulation of mucus secretion IEA
 biological_processGO:0097746 regulation of blood vessel diameter IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
P2Y receptors
Surfactant metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001765 abnormal ion homeostasis "anomaly in the state of equilibrium in the body with respect to charged molecules in the fluids and tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Agrnnmf380/Agrnnmf380
Genetic Background: C57BL/6J-Agrnnmf380/J

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agrnnmf380/Agrnnmf380
Genetic Background: C57BL/6J-Agrnnmf380/J

Allelic Composition: P2ry2tm1Bhk/P2ry2tm1Bhk
Genetic Background: involves: 129P2/OlaHsd

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: P2ry2tm1Bhk/P2ry2tm1Bhk
Genetic Background: involves: 129P2/OlaHsd

 MP:0005591 decreased vasodilation "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: P2ry2tm1Bhk/P2ry2tm1Bhk
Genetic Background: involves: 129P2/OlaHsd

 MP:0012045 increased susceptibility to hypertension "more likely than normal to develop sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [MGI:Nicole]
Show

Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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