ENSMUSG00000027765


Mus musculus

Features
Gene ID: ENSMUSG00000027765
  
Biological name :P2ry1
  
Synonyms : P2ry1 / P49650 / purinergic receptor P2Y, G-protein coupled 1
  
Possible biological names infered from orthology : P47900 / purinergic receptor P2Y1
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: E1
Gene start: 61002795
Gene end: 61008982
  
Corresponding Affymetrix probe sets: 10492330 (MoGene1.0st)   1421456_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029331
Ensembl peptide - ENSMUSP00000141371
Ensembl peptide - ENSMUSP00000142006
NCBI entrez gene - 18441     See in Manteia.
MGI - MGI:105049
RefSeq - NM_001282016
RefSeq - NM_008772
RefSeq Peptide - NP_001268945
RefSeq Peptide - NP_032798
swissprot - P49650
swissprot - Q544J5
Ensembl - ENSMUSG00000027765
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p2ry1ENSDARG00000105281Danio rerio
 P2RY1ENSGALG00000010357Gallus gallus
 P2RY1ENSG00000169860Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P2ry4 / Q9JJS7 / P2Y purinoceptor 4 / P51582* / pyrimidinergic receptor P2Y4*ENSMUSG0000004435935
P2ry2 / purinergic receptor P2Y2 / P41231*ENSMUSG0000003286032
Oxgr1 / Q6IYF8 / 2-oxoglutarate receptor 1 / Q96P68* / oxoglutarate receptor 1*ENSMUSG0000004481930
Q99MT6 / Sucnr1 / Succinate receptor 1 / Q9BXA5*ENSMUSG0000002776228
P2ry6 / Q9ERK9 / P2Y purinoceptor 6 / Q15077* / pyrimidinergic receptor P2Y6*ENSMUSG0000004877928
Gpr17 / Q6NS65 / Uracil nucleotide/cysteinyl leukotriene receptor / Q13304* / G protein-coupled receptor 17*ENSMUSG0000005222926
Q99JA4 / Cysltr1 / Cysteinyl leukotriene receptor 1 / Q9Y271*ENSMUSG0000005282126
Lpar6 / Q8BMC0 / Lysophosphatidic acid receptor 6 / P43657*ENSMUSG0000003344625
Lpar4 / Q8BLG2 / Lysophosphatidic acid receptor 4 / Q99677*ENSMUSG0000004992924
Gpr183 / Q3U6B2 / G protein-coupled receptor 183 / P32249*ENSMUSG0000005121224
Gpr174 / Q3U507 / G protein-coupled receptor 174 / Q9BXC1*ENSMUSG0000007300824
Ptafr / Q62035 / Platelet-activating factor receptor / P25105*ENSMUSG0000005652923
P2ry10 / Q8BFU7 / Mus musculus purinergic receptor P2Y, G-protein coupled 10 (P2ry10), transcript variant 2, mRNA. / O00398* / P2Y receptor family member 10*ENSMUSG0000005092123
P2ry10b / purinergic receptor P2Y, G-protein coupled 10BENSMUSG0000005429323
Q920A1 / Cysltr2 / Cysteinyl leukotriene receptor 2 / Q9NS75*ENSMUSG0000003347022
Lpar5 / lysophosphatidic acid receptor 5 / Q9H1C0*ENSMUSG0000006771422


Protein motifs (from Interpro)
Interpro ID Name
 IPR000142  P2Y purinoceptor 1
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001973 adenosine receptor signaling pathway IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008347 glial cell migration IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010700 negative regulation of norepinephrine secretion IEA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0023019 signal transduction involved in regulation of gene expression IEA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0032962 positive regulation of inositol trisphosphate biosynthetic process IEA
 biological_processGO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0043270 positive regulation of ion transport IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046887 positive regulation of hormone secretion IEA
 biological_processGO:0051100 negative regulation of binding IEA
 biological_processGO:0060406 positive regulation of penile erection IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070848 response to growth factor IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0090075 relaxation of muscle IEA
 biological_processGO:0097746 regulation of blood vessel diameter IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0031686 A1 adenosine receptor binding IEA
 molecular_functionGO:0043531 ADP binding IEA
 molecular_functionGO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA
 molecular_functionGO:0045031 ATP-activated adenosine receptor activity IEA
 molecular_functionGO:0045032 ADP-activated adenosine receptor activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
P2Y receptors
ADP signalling through P2Y purinoceptor 1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitlSl-17H/KitlSl-con
Genetic Background: involves: C3H/HeH

 MP:0003422 abnormal thrombolysis "altered ability to break up (lyse) blood clots that are restricting the blood flow" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:17427]
Show

Allelic Composition: P2ry1tm1Bhk/P2ry1tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: KitlSl-17H/KitlSl-con
Genetic Background: involves: C3H/HeH

Allelic Composition: P2ry1tm1Bhk/P2ry1tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
Show

Allelic Composition: KitlSl-17H/KitlSl-con
Genetic Background: involves: C3H/HeH

Allelic Composition: P2ry1tm1Gac/P2ry1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: P2ry1tm1Bhk/P2ry1tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024639 Gnaq / P21279 / guanine nucleotide binding protein, alpha q polypeptide / P50148* / G protein subunit alpha q*  / complex
 ENSMUSG00000024697 Gna14 / P30677 / guanine nucleotide binding protein, alpha 14 / O95837* / G protein subunit alpha 14*  / complex
 ENSMUSG00000034792 Gna15 / P30678 / guanine nucleotide binding protein, alpha 15 / P30679* / G protein subunit alpha 15*  / complex
 ENSMUSG00000034781 Gna11 / P21278 / guanine nucleotide binding protein, alpha 11 / P29992* / G protein subunit alpha 11*  / complex
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / complex
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / complex






 

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