ENSMUSG00000049929


Mus musculus

Features
Gene ID: ENSMUSG00000049929
  
Biological name :Lpar4
  
Synonyms : Lpar4 / Lysophosphatidic acid receptor 4 / Q8BLG2
  
Possible biological names infered from orthology : Q99677
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: D
Gene start: 106920625
Gene end: 106933900
  
Corresponding Affymetrix probe sets: 10601412 (MoGene1.0st)   1434186_at (Mouse Genome 430 2.0 Array)   1439665_at (Mouse Genome 430 2.0 Array)   1452424_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053986
NCBI entrez gene - 78134     See in Manteia.
MGI - MGI:1925384
RefSeq - NM_175271
RefSeq Peptide - NP_780480
swissprot - Q8BLG2
Ensembl - ENSMUSG00000049929
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lpar4ENSDARG00000089824Danio rerio
 LPAR4ENSGALG00000004121Gallus gallus
 LPAR4ENSG00000147145Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lpar6 / Q8BMC0 / Lysophosphatidic acid receptor 6 / P43657*ENSMUSG0000003344649
Lpar5 / lysophosphatidic acid receptor 5 / Q9H1C0*ENSMUSG0000006771430
Gpr174 / Q3U507 / G protein-coupled receptor 174 / Q9BXC1*ENSMUSG0000007300829
Ptafr / Q62035 / Platelet-activating factor receptor / P25105*ENSMUSG0000005652927
P2ry10 / Q8BFU7 / Mus musculus purinergic receptor P2Y, G-protein coupled 10 (P2ry10), transcript variant 2, mRNA. / O00398* / P2Y receptor family member 10*ENSMUSG0000005092127
P2ry2 / purinergic receptor P2Y2 / P41231*ENSMUSG0000003286026
Q99JA4 / Cysltr1 / Cysteinyl leukotriene receptor 1 / Q9Y271*ENSMUSG0000005282126
P2ry4 / Q9JJS7 / P2Y purinoceptor 4 / P51582* / pyrimidinergic receptor P2Y4*ENSMUSG0000004435926
P2ry10b / purinergic receptor P2Y, G-protein coupled 10BENSMUSG0000005429326
P2ry6 / Q9ERK9 / P2Y purinoceptor 6 / Q15077* / pyrimidinergic receptor P2Y6*ENSMUSG0000004877925
P2ry1 / P49650 / purinergic receptor P2Y, G-protein coupled 1 / P47900* / purinergic receptor P2Y1*ENSMUSG0000002776525
Gpr17 / Q6NS65 / Uracil nucleotide/cysteinyl leukotriene receptor / Q13304* / G protein-coupled receptor 17*ENSMUSG0000005222925
Gpr183 / Q3U6B2 / G protein-coupled receptor 183 / P32249*ENSMUSG0000005121224
Q920A1 / Cysltr2 / Cysteinyl leukotriene receptor 2 / Q9NS75*ENSMUSG0000003347024
Oxgr1 / Q6IYF8 / 2-oxoglutarate receptor 1 / Q96P68* / oxoglutarate receptor 1*ENSMUSG0000004481923
Q99MT6 / Sucnr1 / Succinate receptor 1 / Q9BXA5*ENSMUSG0000002776221


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0035025 positive regulation of Rho protein signal transduction IBA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IBA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0035727 lysophosphatidic acid binding IDA
 molecular_functionGO:0070915 lysophosphatidic acid receptor activity IDA


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
P2Y receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000087 absent mandible "missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Alkbh1tm1Klng/Alkbh1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
Show

Allelic Composition: Alkbh1tm1Klng/Alkbh1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Alkbh1tm1Klng/Alkbh1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Alkbh1tm1Klng/Alkbh1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Alkbh1tm1Klng/Alkbh1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Alkbh1tm1Klng/Alkbh1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0001784 abnormal fluid regulation "anomalous control of intracellular and/or extracellular fluid " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Alkbh1tm1Klng/Alkbh1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
Show

Allelic Composition: Alkbh1tm1Klng/Alkbh1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Alkbh1tm1Klng/Alkbh1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Alkbh1tm1Klng/Alkbh1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0003719 abnormal pericyte morphology "malformation in the connective tissue cells that occurs around capillaries or other small blood vessels " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Alkbh1tm1Klng/Alkbh1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0003814 vascular smooth muscle cell hypoplasia "decreased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Alkbh1tm1Klng/Alkbh1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0004038 lymphangiectasis "dilation of the lymphatic vessels, the basic process that may result in the formation of a lymphangioma" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:71816]
Show

Allelic Composition: Alkbh1tm1Klng/Alkbh1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alkbh1tm1Klng/Alkbh1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Alkbh1tm1Klng/Alkbh1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Alkbh1tm1Klng/Alkbh1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Alkbh1tm1Klng/Alkbh1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Alkbh1tm1Klng/Alkbh1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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