ENSMUSG00000033470


Mus musculus

Features
Gene ID: ENSMUSG00000033470
  
Biological name :Cysltr2
  
Synonyms : Cysltr2 / Cysteinyl leukotriene receptor 2 / Q920A1
  
Possible biological names infered from orthology : Q9NS75
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D3
Gene start: 73025603
Gene end: 73049114
  
Corresponding Affymetrix probe sets: 10421517 (MoGene1.0st)   1421642_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040715
Ensembl peptide - ENSMUSP00000125958
NCBI entrez gene - 70086     See in Manteia.
MGI - MGI:1917336
RefSeq - XM_011245178
RefSeq - NM_001162412
RefSeq - NM_133720
RefSeq Peptide - NP_598481
RefSeq Peptide - NP_001155884
swissprot - Q920A1
Ensembl - ENSMUSG00000033470
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9NS75ENSG00000152207Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99JA4 / Cysltr1 / Cysteinyl leukotriene receptor 1 / Q9Y271*ENSMUSG0000005282137
P2ry2 / purinergic receptor P2Y2 / P41231*ENSMUSG0000003286030
Oxgr1 / Q6IYF8 / 2-oxoglutarate receptor 1 / Q96P68* / oxoglutarate receptor 1*ENSMUSG0000004481930
Gpr17 / Q6NS65 / Uracil nucleotide/cysteinyl leukotriene receptor / Q13304* / G protein-coupled receptor 17*ENSMUSG0000005222929
Lpar6 / Q8BMC0 / Lysophosphatidic acid receptor 6 / P43657*ENSMUSG0000003344629
Lpar4 / Q8BLG2 / Lysophosphatidic acid receptor 4 / Q99677*ENSMUSG0000004992929
Gpr174 / Q3U507 / G protein-coupled receptor 174 / Q9BXC1*ENSMUSG0000007300828
Gpr183 / Q3U6B2 / G protein-coupled receptor 183 / P32249*ENSMUSG0000005121228
Lpar5 / lysophosphatidic acid receptor 5 / Q9H1C0*ENSMUSG0000006771427
P2ry6 / Q9ERK9 / P2Y purinoceptor 6 / Q15077* / pyrimidinergic receptor P2Y6*ENSMUSG0000004877927
P2ry1 / P49650 / purinergic receptor P2Y, G-protein coupled 1 / P47900* / purinergic receptor P2Y1*ENSMUSG0000002776527
P2ry10b / purinergic receptor P2Y, G-protein coupled 10BENSMUSG0000005429326
Q99MT6 / Sucnr1 / Succinate receptor 1 / Q9BXA5*ENSMUSG0000002776226
P2ry10 / Q8BFU7 / Mus musculus purinergic receptor P2Y, G-protein coupled 10 (P2ry10), transcript variant 2, mRNA. / O00398* / P2Y receptor family member 10*ENSMUSG0000005092126
Ptafr / Q62035 / Platelet-activating factor receptor / P25105*ENSMUSG0000005652925
P2ry4 / Q9JJS7 / P2Y purinoceptor 4 / P51582* / pyrimidinergic receptor P2Y4*ENSMUSG0000004435925


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR004071  Cysteinyl leukotriene receptor
 IPR013311  Cysteinyl leukotriene receptor 2
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007218 neuropeptide signaling pathway IBA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0061737 leukotriene signaling pathway IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001631 cysteinyl leukotriene receptor activity IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004974 leukotriene receptor activity IEA
 molecular_functionGO:0008528 G-protein coupled peptide receptor activity IBA


Pathways (from Reactome)
Pathway description
Leukotriene receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adamts20bt-2H/Adamts20bt-2H,Kittm1Alf/Kit+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ubr4tm1.2Nkt/Ubr4tm1.2Nkt,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

Allelic Composition: Cysltr1tm1Ykn/Cysltr1tm1Ykn,Cysltr2tm1Ykn/Cysltr2tm1Ykn,Oxgr1tm1(KOMP)Vlcg/Oxgr1tm1(KOMP)Vlcg
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NTac

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc6a3tm2(tTA)Xz/Slc6a3+,Tg(tetO-COX8A/PstI*)1Ctm/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * SJL

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc6a3tm2(tTA)Xz/Slc6a3+,Tg(tetO-COX8A/PstI*)1Ctm/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * SJL

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006050 pulmonary fibrosis "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009811 abnormal prostaglandin level "anomaly in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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