ENSG00000244165


Homo sapiens

Features
Gene ID: ENSG00000244165
  
Biological name :P2RY11
  
Synonyms : P2RY11 / purinergic receptor P2Y11 / Q96G91
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.2
Gene start: 10111538
Gene end: 10115372
  
Corresponding Affymetrix probe sets: 214546_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000323872
NCBI entrez gene - 5032     See in Manteia.
OMIM - 602697
RefSeq - NM_002566
RefSeq Peptide - NP_002557
swissprot - Q96G91
Ensembl - ENSG00000244165
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p2ry11ENSDARG00000014929Danio rerio


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PPAN-P2RY11 / PPAN-P2RY11 readthroughENSG0000024320799
P2RY4 / P51582 / pyrimidinergic receptor P2Y4ENSG0000018691228
P2RY1 / P47900 / purinergic receptor P2Y1ENSG0000016986027
P2RY2 / P41231 / purinergic receptor P2Y2ENSG0000017559124
GPR17 / Q13304 / G protein-coupled receptor 17ENSG0000014423023
Q9BXA5 / SUCNR1 / succinate receptor 1ENSG0000019882922
OXGR1 / Q96P68 / oxoglutarate receptor 1ENSG0000016562121
P2RY6 / Q15077 / pyrimidinergic receptor P2Y6ENSG0000017163121
LPAR4 / Q99677 / lysophosphatidic acid receptor 4ENSG0000014714520
Q9Y271 / CYSLTR1 / cysteinyl leukotriene receptor 1ENSG0000017319819
Q9NS75 / CYSLTR2 / cysteinyl leukotriene receptor 2ENSG0000015220719
GPR183 / P32249 / G protein-coupled receptor 183ENSG0000016950818
LPAR6 / P43657 / lysophosphatidic acid receptor 6ENSG0000013967918
LPAR5 / Q9H1C0 / lysophosphatidic acid receptor 5ENSG0000018457418
GPR174 / Q9BXC1 / G protein-coupled receptor 174ENSG0000014713817
O00398 / P2RY10 / P2Y receptor family member 10ENSG0000007858917
PTAFR / P25105 / platelet activating factor receptorENSG0000016940315


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR027677  P2Y11 purinoceptor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001973 adenosine receptor signaling pathway IEA
 biological_processGO:0006952 defense response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007190 activation of adenylate cyclase activity TAS
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS
 biological_processGO:0019722 calcium-mediated signaling IDA
 biological_processGO:0023041 neuronal signal transduction IDA
 biological_processGO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA
 biological_processGO:0071318 cellular response to ATP IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IC
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0030594 neurotransmitter receptor activity IDA
 molecular_functionGO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA
 molecular_functionGO:0045031 ATP-activated adenosine receptor activity IDA


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
P2Y receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000504 Abnormality of vision "Abnormality of eyesight (visual perception)." [HPO:curators]
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 HP:0000738 Hallucinations 
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 HP:0001279 Syncope "Syncope refers to a generalized weakness of muscles with loss of postural tone, inability to stand upright, and loss of consciousness. Once the patient is in a horizontal position, blood flow to the brain is no longer hindered by gravitation and consciousness is regained. Unconsciousness usually lasts for seconds to minutes. Headache and drowsiness (which usually follow seizures) do not follow a syncopal attack. Syncope results from a sudden impairment of brain metabolism usually due to a reduction in cerebral blood flow. This term refers to an abnormally increased disposition to syncope." [HPO:curators]
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 HP:0001350 Slurred speech 
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 HP:0001513 Obesity "A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY)." [MeSH:D009765]
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 HP:0002189 Excessive daytime sleepiness 
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 HP:0002494 Abnormal rapid eye movement (REM) sleep "Abnormality of REM sleep. Phases of REM sleep are characterized by desynchronized EEG patterns, increases in heart rate and blood pressure, sympathetic activation, and a profound loss of muscle tonus except for the eye and middle-ear muscles. There are then phases of rapid eye movements." [HPO:curators]
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 HP:0002524 Cataplexy 
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 HP:0010534 Transient global amnesia "A paroxysmal, transient loss of memory function with preservation of immediate recall and remote memory but with a severe impairment of memory for recent events and ability to retain new information." [HPO:curators]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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