ENSG00000112038


Homo sapiens

Features
Gene ID: ENSG00000112038
  
Biological name :OPRM1
  
Synonyms : opioid receptor mu 1 / OPRM1 / P35372
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: q25.2
Gene start: 154010496
Gene end: 154246867
  
Corresponding Affymetrix probe sets: 207989_at (Human Genome U133 Plus 2.0 Array)   207994_s_at (Human Genome U133 Plus 2.0 Array)   211359_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000430876
Ensembl peptide - ENSP00000430575
Ensembl peptide - ENSP00000431048
Ensembl peptide - ENSP00000229768
Ensembl peptide - ENSP00000328264
Ensembl peptide - ENSP00000338381
Ensembl peptide - ENSP00000353598
Ensembl peptide - ENSP00000394624
Ensembl peptide - ENSP00000399359
Ensembl peptide - ENSP00000403549
Ensembl peptide - ENSP00000410497
Ensembl peptide - ENSP00000411903
Ensembl peptide - ENSP00000413752
Ensembl peptide - ENSP00000428018
Ensembl peptide - ENSP00000429373
Ensembl peptide - ENSP00000429719
Ensembl peptide - ENSP00000430097
Ensembl peptide - ENSP00000430247
Ensembl peptide - ENSP00000430260
NCBI entrez gene - 4988     See in Manteia.
OMIM - 600018
RefSeq - NM_001008505
RefSeq - NM_001145280
RefSeq - NM_001145281
RefSeq - NM_001145282
RefSeq - NM_001145283
RefSeq - NM_001145284
RefSeq - NM_001145285
RefSeq - NM_001145286
RefSeq - NM_001145287
RefSeq - NM_001285523
RefSeq - NM_001285524
RefSeq - NM_001285526
RefSeq - NM_001285527
RefSeq - NM_001285528
RefSeq - XM_011535851
RefSeq - XM_011535853
RefSeq - XM_011535856
RefSeq - XM_011535862
RefSeq - XM_017010903
RefSeq - XM_017010904
RefSeq - XM_017010905
RefSeq - XM_017010906
RefSeq - NM_000914
RefSeq - NM_001008503
RefSeq - NM_001008504
RefSeq - NM_001145279
RefSeq Peptide - NP_001008503
RefSeq Peptide - NP_001008504
RefSeq Peptide - NP_001008505
RefSeq Peptide - NP_001138751
RefSeq Peptide - NP_001272456
RefSeq Peptide - NP_001272457
RefSeq Peptide - NP_000905
RefSeq Peptide - NP_001138752
RefSeq Peptide - NP_001138753
RefSeq Peptide - NP_001138754
RefSeq Peptide - NP_001138755
RefSeq Peptide - NP_001138756
RefSeq Peptide - NP_001138757
RefSeq Peptide - NP_001138758
RefSeq Peptide - NP_001138759
RefSeq Peptide - NP_001272452
RefSeq Peptide - NP_001272453
RefSeq Peptide - NP_001272455
swissprot - E7EW71
swissprot - L0E130
swissprot - P35372
Ensembl - ENSG00000112038
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 oprm1ENSDARG00000039434Danio rerio
 OPRM1ENSGALG00000013616Gallus gallus
 Oprm1ENSMUSG00000000766Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
OPRD1 / P41143 / opioid receptor delta 1ENSG0000011632946
OPRK1 / P41145 / opioid receptor kappa 1ENSG0000008255645
OPRL1 / P41146 / opioid related nociceptin receptor 1ENSG0000012551037
SSTR2 / P30874 / somatostatin receptor 2ENSG0000018061627
SSTR1 / P30872 / somatostatin receptor 1ENSG0000013987427
SSTR4 / P31391 / somatostatin receptor 4ENSG0000013267125
SSTR3 / P32745 / somatostatin receptor 3ENSG0000027819525
NPBWR2 / P48146 / neuropeptides B and W receptor 2ENSG0000012552225
SSTR5 / P35346 / somatostatin receptor 5ENSG0000016200925
NPBWR1 / P48145 / neuropeptides B and W receptor 1ENSG0000018372922
MCHR2 / Q969V1 / melanin concentrating hormone receptor 2ENSG0000015203419
MCHR1 / Q99705 / melanin concentrating hormone receptor 1ENSG0000012828519


Protein motifs (from Interpro)
Interpro ID Name
 IPR000105  Mu opioid receptor
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001418  Opioid receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002438 acute inflammatory response to antigenic stimulus IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
 biological_processGO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway IEA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007194 negative regulation of adenylate cyclase activity ISS
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007600 sensory perception NAS
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0019233 sensory perception of pain IBA
 biological_processGO:0031635 adenylate cyclase-inhibiting opioid receptor signaling pathway IEA
 biological_processGO:0032094 response to food IEA
 biological_processGO:0032100 positive regulation of appetite IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0038003 opioid receptor signaling pathway IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0044849 estrous cycle IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0048149 behavioral response to ethanol IMP
 biological_processGO:0050769 positive regulation of neurogenesis ISS
 biological_processGO:0051930 regulation of sensory perception of pain IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0061358 negative regulation of Wnt protein secretion IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0070848 response to growth factor IEA
 biological_processGO:0071315 cellular response to morphine IBA
 biological_processGO:0080135 regulation of cellular response to stress IMP
 biological_processGO:0106072 negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:2000310 regulation of NMDA receptor activity ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005783 endoplasmic reticulum TAS
 cellular_componentGO:0005794 Golgi apparatus TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0032590 dendrite membrane IEA
 cellular_componentGO:0032839 dendrite cytoplasm IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IBA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004979 beta-endorphin receptor activity IEA
 molecular_functionGO:0004985 opioid receptor activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031005 filamin binding IEA
 molecular_functionGO:0031681 G-protein beta-subunit binding IBA
 molecular_functionGO:0038047 morphine receptor activity IBA
 molecular_functionGO:0042923 neuropeptide binding IBA


Pathways (from Reactome)
Pathway description
Opioid Signalling
G-protein activation
Peptide ligand-binding receptors
G alpha (i) signalling events
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101327 PDYN / P01213 / prodynorphin  / complex / reaction
 ENSG00000115138 POMC / P01189 / proopiomelanocortin  / complex / reaction
 ENSG00000186469 GNG2 / P59768 / G protein subunit gamma 2  / reaction / complex
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / complex / reaction






 

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