ENSMUSG00000000766


Mus musculus

Features
Gene ID: ENSMUSG00000000766
  
Biological name :Oprm1
  
Synonyms : opioid receptor, mu 1 / Oprm1 / P42866
  
Possible biological names infered from orthology : P35372
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: A1
Gene start: 6758506
Gene end: 7038198
  
Corresponding Affymetrix probe sets: 1425432_at (Mouse Genome 430 2.0 Array)   1451705_a_at (Mouse Genome 430 2.0 Array)   1451709_at (Mouse Genome 430 2.0 Array)   1459402_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115413
Ensembl peptide - ENSMUSP00000135143
Ensembl peptide - ENSMUSP00000123617
Ensembl peptide - ENSMUSP00000123117
Ensembl peptide - ENSMUSP00000122385
Ensembl peptide - ENSMUSP00000120187
Ensembl peptide - ENSMUSP00000117950
Ensembl peptide - ENSMUSP00000115836
Ensembl peptide - ENSMUSP00000115552
Ensembl peptide - ENSMUSP00000000783
Ensembl peptide - ENSMUSP00000053498
Ensembl peptide - ENSMUSP00000060329
Ensembl peptide - ENSMUSP00000060590
Ensembl peptide - ENSMUSP00000077704
Ensembl peptide - ENSMUSP00000090405
Ensembl peptide - ENSMUSP00000090407
Ensembl peptide - ENSMUSP00000090410
Ensembl peptide - ENSMUSP00000101222
Ensembl peptide - ENSMUSP00000101226
Ensembl peptide - ENSMUSP00000101227
Ensembl peptide - ENSMUSP00000101228
Ensembl peptide - ENSMUSP00000101229
Ensembl peptide - ENSMUSP00000101230
Ensembl peptide - ENSMUSP00000101232
Ensembl peptide - ENSMUSP00000101236
Ensembl peptide - ENSMUSP00000101240
Ensembl peptide - ENSMUSP00000114342
Ensembl peptide - ENSMUSP00000114856
NCBI entrez gene - 18390     See in Manteia.
MGI - MGI:97441
RefSeq - XM_017313828
RefSeq - NM_001039652
RefSeq - NM_001302793
RefSeq - NM_001302794
RefSeq - NM_001302795
RefSeq - NM_001302796
RefSeq - NM_001304937
RefSeq - NM_001304938
RefSeq - NM_001304948
RefSeq - NM_001304950
RefSeq - NM_001304955
RefSeq - XM_006512437
RefSeq - XM_017313826
RefSeq - XM_017313827
RefSeq Peptide - NP_001289724
RefSeq Peptide - NP_001289725
RefSeq Peptide - NP_001034741
RefSeq Peptide - NP_001289722
RefSeq Peptide - NP_001291866
RefSeq Peptide - NP_001291867
RefSeq Peptide - NP_001291877
RefSeq Peptide - NP_001291879
RefSeq Peptide - NP_001291884
RefSeq Peptide - NP_001289723
swissprot - E9Q7D4
swissprot - Q4U2P0
swissprot - P42866
swissprot - Q4U2P1
swissprot - Q4U2P9
swissprot - E9QAQ1
swissprot - E9Q7D3
swissprot - E9Q2X5
swissprot - E9Q270
swissprot - E9PVC1
swissprot - A1KZZ4
swissprot - A0A0R4J0Z2
Ensembl - ENSMUSG00000000766
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 oprm1ENSDARG00000039434Danio rerio
 OPRM1ENSGALG00000013616Gallus gallus
 OPRM1ENSG00000112038Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Oprd1 / P32300 / opioid receptor, delta 1 / P41143*ENSMUSG0000005051151
Oprk1 / P33534 / Kappa-type opioid receptor / P41145* / opioid receptor kappa 1*ENSMUSG0000002590550
Oprl1 / P35377 / opioid receptor-like 1 / P41146* / opioid related nociceptin receptor 1*ENSMUSG0000002758442
Sstr2 / P30875 / Somatostatin receptor type 2 / P30874* / somatostatin receptor 2*ENSMUSG0000004790431
Sstr1 / P30873 / somatostatin receptor 1 / P30872*ENSMUSG0000003543130
Sstr3 / P30935 / Somatostatin receptor type 3 / P32745* / somatostatin receptor 3*ENSMUSG0000004493329
Sstr5 / O08858 / Somatostatin receptor type 5 / P35346* / somatostatin receptor 5*ENSMUSG0000005082429
Sstr4 / somatostatin receptor 4 / P31391*ENSMUSG0000003701428
Npbwr1 / P49681 / Neuropeptides B/W receptor type 1 / P48145* / neuropeptides B and W receptor 1*ENSMUSG0000003377425
Mchr1 / Q8JZL2 / Melanin-concentrating hormone receptor 1 / Q99705*ENSMUSG0000005016421


Protein motifs (from Interpro)
Interpro ID Name
 IPR000105  Mu opioid receptor
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001418  Opioid receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002438 acute inflammatory response to antigenic stimulus IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway IDA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007194 negative regulation of adenylate cyclase activity ISS
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISO
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0031635 adenylate cyclase-inhibiting opioid receptor signaling pathway IEA
 biological_processGO:0032094 response to food IEA
 biological_processGO:0032100 positive regulation of appetite IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0038003 opioid receptor signaling pathway IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling ISO
 biological_processGO:0043951 negative regulation of cAMP-mediated signaling ISS
 biological_processGO:0044849 estrous cycle IEA
 biological_processGO:0045019 negative regulation of nitric oxide biosynthetic process ISO
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process ISO
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0048149 behavioral response to ethanol ISO
 biological_processGO:0050769 positive regulation of neurogenesis IMP
 biological_processGO:0051481 negative regulation of cytosolic calcium ion concentration ISO
 biological_processGO:0051930 regulation of sensory perception of pain IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0061358 negative regulation of Wnt protein secretion ISO
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0070848 response to growth factor IEA
 biological_processGO:0071315 cellular response to morphine IBA
 biological_processGO:0080135 regulation of cellular response to stress IEA
 biological_processGO:0106072 negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:2000310 regulation of NMDA receptor activity ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0032590 dendrite membrane IEA
 cellular_componentGO:0032839 dendrite cytoplasm IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IBA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity ISS
 molecular_functionGO:0004979 beta-endorphin receptor activity ISO
 molecular_functionGO:0004985 opioid receptor activity IDA
 molecular_functionGO:0005245 voltage-gated calcium channel activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031005 filamin binding IEA
 molecular_functionGO:0031681 G-protein beta-subunit binding IBA
 molecular_functionGO:0038047 morphine receptor activity IBA
 molecular_functionGO:0042923 neuropeptide binding IBA


Pathways (from Reactome)
Pathway description
Opioid Signalling
G-protein activation
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hnf4atm2Mwei/Hnf4atm2Mwei
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Oprm1tm1Jep/Oprm1+
Genetic Background: involves: 129S/SvEv

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trim62tm1Akil/Trim62+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Ryr1tm1.1Inp/Ryr1tm1.1Inp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001380 male reduced copulation without impotence "males do not initiate sexual behavior as scored by the presence of copulation plugs (not due to infertility)" [J:57125]
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Allelic Composition: Oprm1tm1Lyu/Oprm1tm1Lyu
Genetic Background: involves: Black Swiss

Allelic Composition: Oprm1tm1Lyu/Oprm1+
Genetic Background: involves: Black Swiss

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Oprm1tm1Lyu/Oprm1tm1Lyu
Genetic Background: involves: Black Swiss

Allelic Composition: Oprm1tm1Lyu/Oprm1+
Genetic Background: involves: Black Swiss

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Foxa2tm1Jrt/Foxa2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Oprm1tm1Lyu/Oprm1tm1Lyu
Genetic Background: involves: Black Swiss

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Oprm1tm1Lyu/Oprm1tm1Lyu
Genetic Background: involves: Black Swiss

 MP:0001968 abnormal touch/ nociception "change in the ability to sense contact with objects or in the ability to sense pain, most often registered by mechanoreceptors in the skin and mucous membranes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ntsr1tm2Dgen/Ntsr1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
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Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Oprm1tm1Uhl/Oprm1tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Oprm1tm1Lex/Oprm1tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6NTac

 MP:0001980 abnormal chemically-elicited antinociception "change in the analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppp1r13ltm1.1Xlu/Ppp1r13l+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6J

 MP:0001981 enhanced chemically-elicited antinociception "greater than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: msp4/msp4,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

Allelic Composition: Oprm1tm1Shlz/Oprm1tm1Shlz
Genetic Background: involves: C57BL/6

 MP:0001982 reduced chemically-elicited antinociception "less than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxa2tm1Jrt/Foxa2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Oprm1tm1Loh/Oprm1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Oprm1tm1Yxp/Oprm1tm1Yxp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Oprm1tm1Lyu/Oprm1tm1Lyu
Genetic Background: involves: Black Swiss

Allelic Composition: Oprm1tm1Jabl/Oprm1tm1Jabl
Genetic Background: C57BL/6-Oprm1tm1Jabl

Allelic Composition: Oprm1tm1Lex/Oprm1tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6NTac

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Oprm1tm1Jep/Oprm1+
Genetic Background: involves: 129S/SvEv

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntsr1tm2Dgen/Ntsr1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Oprm1tm1Lyu/Oprm1tm1Lyu
Genetic Background: involves: Black Swiss

Allelic Composition: Oprm1tm1Lyu/Oprm1+
Genetic Background: involves: Black Swiss

 MP:0002578 impaired ability to fire action potentials "anomaly resulting in reduced changes in membrane potentials occurring in nerve or other excitable tissue when excitation occurs" [J:51377, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Oprm1tm1Jep/Oprm1+
Genetic Background: involves: 129S/SvEv

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Oprm1tm1Lyu/Oprm1tm1Lyu
Genetic Background: involves: Black Swiss

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Oprm1tm1Lyu/Oprm1tm1Lyu
Genetic Background: involves: Black Swiss

 MP:0002803 abnormal operant conditional behavior "defects in the operant conditioning system refers to abnormalities in scheduled controlled behavior; behavioral assessment occurs in an automated chamber where responses are reinforced with food" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Oprm1tm1Jep/Oprm1+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Oprm1tm1Jep/Oprm1+
Genetic Background: B6.129S-Oprm1tm1Jep

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Oprm1tm1Jep/Oprm1+
Genetic Background: involves: 129S/SvEv

 MP:0003063 increased coping response "enhanced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]
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Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Oprm1tm1Lyu/Oprm1tm1Lyu
Genetic Background: involves: Black Swiss

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd

 MP:0003959 abnormal lean body mass "aberrant fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Oprm1tm1Jep/Oprm1+
Genetic Background: involves: 129S/SvEv

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Oprm1tm1Uhl/Oprm1tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Oprm1tm1Jabl/Oprm1tm1Jabl
Genetic Background: C57BL/6-Oprm1tm1Jabl

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Oprm1tm1Jep/Oprm1+
Genetic Background: involves: 129S/SvEv

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oprm1tm1Jep/Oprm1+
Genetic Background: involves: 129S/SvEv

 MP:0006001 abnormal intestinal transit time "increase or decrease in the time it takes for a bolus of material to pass through the intestine" [smb:Susan M Bello, Mouse Genome Iformatics Curator]
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Allelic Composition: Oprm1tm1Yxp/Oprm1tm1Yxp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprm1tm1Lyu/Oprm1tm1Lyu
Genetic Background: involves: Black Swiss

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lcattm1Hgc/Lcattm1Hgc
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprm1tm1Uhl/Oprm1tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Oprm1tm1Lex/Oprm1tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6NTac

Allelic Composition: Oprm1tm1.2Cgrf/Oprm1tm1.2Cgrf
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0008911 induced hyperactivity "increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprm1tm1Jep/Oprm1+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Oprm1tm1Jep/Oprm1+
Genetic Background: B6.129S-Oprm1tm1Jep

 MP:0009108 increased pancreas weight "increase in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [MESH:A03.734, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprm1tm1Jep/Oprm1+
Genetic Background: involves: 129S/SvEv

 MP:0009171 enlarged pancreatic islets "increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Oprm1tm1Jep/Oprm1+
Genetic Background: involves: 129S/SvEv

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprm1tm1Lyu/Oprm1tm1Lyu
Genetic Background: involves: Black Swiss

Allelic Composition: Oprm1tm1Lyu/Oprm1+
Genetic Background: involves: Black Swiss

 MP:0009336 increased splenocyte proliferation "increase in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprm1tm1Lyu/Oprm1tm1Lyu
Genetic Background: involves: Black Swiss

Allelic Composition: Oprm1tm1Lyu/Oprm1+
Genetic Background: involves: Black Swiss

 MP:0009712 impaired conditioned place preference behavior "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprm1tm1Jabl/Oprm1tm1Jabl
Genetic Background: C57BL/6-Oprm1tm1Jabl

 MP:0009713 enhanced conditioned place preference behavior "increase in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprm1tm1Uhl/Oprm1tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009748 abnormal behavioral response to addictive substance "any anomaly in the behavioral response induced by an addictive substance, such as induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: msp4/msp4,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

Allelic Composition: Oprm1tm1.1Cgrf/Oprm1tm1.1Cgrf,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0009749 enhanced behavioral response to addictive substance "increased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprm1tm1Jep/Oprm1+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Oprm1tm1Jep/Oprm1+
Genetic Background: B6.129S-Oprm1tm1Jep

Allelic Composition: Oprm1tm1.1Jbwa/Oprm1tm1.1Jbwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009753 enhanced behavioral response to morphine "increased sensitivity to morphine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprm1tm1Shlz/Oprm1tm1Shlz
Genetic Background: involves: C57BL/6

 MP:0009754 enhanced behavioral response to cocaine "increased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxa2tm1Jrt/Foxa2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009757 impaired behavioral response to morphine "decreased sensitivity to morphine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Oprm1tm1Uhl/Oprm1tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Oprm1tm1Loh/Oprm1tm1Loh
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Oprm1tm1Lyu/Oprm1tm1Lyu
Genetic Background: involves: Black Swiss

Allelic Composition: Oprm1tm1Lyu/Oprm1+
Genetic Background: involves: Black Swiss

Allelic Composition: Oprm1tm1Jabl/Oprm1tm1Jabl
Genetic Background: C57BL/6-Oprm1tm1Jabl

Allelic Composition: Oprm1tm1Jep/Oprm1tm1Jep
Genetic Background: involves: 129S/SvEv

Allelic Composition: Oprm1tm1Jep/Oprm1+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Oprd1tm1Jep/Oprd1tm1Jep,Oprm1tm1Jep/Oprm1tm1Jep,Oprm1tm1Jep/Oprm1tm1Jep
Genetic Background: involves: 129S/SvEv * 129S2/SvPas

Allelic Composition: Oprm1tm1Lex/Oprm1tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6NTac

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprm1tm1Uhl/Oprm1tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Oprm1tm1Uhl/Oprm1+
Genetic Background: either: B6.129S7-Oprm1tm1Uhl or (involves: 129S7/SvEvBrd)

Allelic Composition: Oprm1tm1Loh/Oprm1tm1Loh
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Oprm1tm1Loh/Oprm1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009776 decreased behavioral withdrawal response "decrease in the intensity or duration of behaviors displayed after discontinuation of an addictive substance" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009778 impaired behavioral response to anesthetic "decrease or delay in the behavioral changes that follow exposure to a given amount of an anesthetizing agent" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Oprm1tm1Jep/Oprm1tm1Jep
Genetic Background: involves: 129S/SvEv

Allelic Composition: Oprm1tm1Jep/Oprm1+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Oprd1tm1Jep/Oprd1tm1Jep,Oprm1tm1Jep/Oprm1tm1Jep,Oprm1tm1Jep/Oprm1tm1Jep
Genetic Background: involves: 129S/SvEv * 129S2/SvPas

 MP:0009779 enhanced behavioral response to anesthetic "increase or exceleration in the behavioral changes that follow exposure to a given amount of an anesthetizing agent" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprm1tm1Jep/Oprm1tm1Jep
Genetic Background: involves: 129S/SvEv

Allelic Composition: Oprm1tm1Jep/Oprm1+
Genetic Background: involves: 129S/SvEv

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprm1tm1Jep/Oprm1+
Genetic Background: involves: 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / complex / reaction
 ENSMUSG00000020660 Pomc / P01193 / pro-opiomelanocortin-alpha / P01189* / proopiomelanocortin*  / reaction / complex
 ENSMUSG00000027400 Pdyn / prodynorphin / P01213*  / reaction / complex
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / reaction / complex






 

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