ENSMUSG00000050164


Mus musculus

Features
Gene ID: ENSMUSG00000050164
  
Biological name :Mchr1
  
Synonyms : Mchr1 / Melanin-concentrating hormone receptor 1 / Q8JZL2
  
Possible biological names infered from orthology : Q99705
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E1
Gene start: 81235499
Gene end: 81238964
  
Corresponding Affymetrix probe sets: 10425507 (MoGene1.0st)   1428031_at (Mouse Genome 430 2.0 Array)   1454844_at (Mouse Genome 430 2.0 Array)   1454845_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126191
NCBI entrez gene - 207911     See in Manteia.
MGI - MGI:2180756
RefSeq - NM_145132
RefSeq Peptide - NP_660114
swissprot - Q8JZL2
Ensembl - ENSMUSG00000050164
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mchr1aENSDARG00000104093Danio rerio
 mchr1bENSDARG00000022525Danio rerio
 MCHR1ENSGALG00000019736Gallus gallus
 MCHR1ENSG00000128285Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sstr3 / P30935 / Somatostatin receptor type 3 / P32745* / somatostatin receptor 3*ENSMUSG0000004493330
Sstr2 / P30875 / Somatostatin receptor type 2 / P30874* / somatostatin receptor 2*ENSMUSG0000004790430
Sstr5 / O08858 / Somatostatin receptor type 5 / P35346* / somatostatin receptor 5*ENSMUSG0000005082429
Sstr1 / P30873 / somatostatin receptor 1 / P30872*ENSMUSG0000003543129
Npbwr1 / P49681 / Neuropeptides B/W receptor type 1 / P48145* / neuropeptides B and W receptor 1*ENSMUSG0000003377429
Sstr4 / somatostatin receptor 4 / P31391*ENSMUSG0000003701428
Oprd1 / P32300 / opioid receptor, delta 1 / P41143*ENSMUSG0000005051127
Oprl1 / P35377 / opioid receptor-like 1 / P41146* / opioid related nociceptin receptor 1*ENSMUSG0000002758426
Oprm1 / P42866 / opioid receptor, mu 1 / P35372*ENSMUSG0000000076626
Oprk1 / P33534 / Kappa-type opioid receptor / P41145* / opioid receptor kappa 1*ENSMUSG0000002590524


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR004047  Melanin-concentrating hormone 1 receptor
 IPR008361  Melanin-concentrating hormone receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007218 neuropeptide signaling pathway IBA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0051928 positive regulation of calcium ion transport IEA
 biological_processGO:0060259 regulation of feeding behavior TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0060170 ciliary membrane IDA
 cellular_componentGO:0097730 non-motile cilium IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008188 neuropeptide receptor activity IBA
 molecular_functionGO:0030273 melanin-concentrating hormone receptor activity IBA
 molecular_functionGO:0042562 hormone binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
BBSome-mediated cargo-targeting to cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Ercc5tm1Shm/Ercc5tm1Shm
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Rassf1tm1Gpp/Rassf1+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

Allelic Composition: Mchr1tm1Dgam/Mchr1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Tnks2tm1.1Susm/Tnks2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Rassf1tm1Gpp/Rassf1+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

Allelic Composition: Mchr1tm1Sqn/Mchr1tm1Sqn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rassf1tm1Gpp/Rassf1+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

Allelic Composition: Mchr1tm1Sqn/Mchr1tm1Sqn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja10tm1Kwi/Gja10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Mchr1tm1Sqn/Mchr1tm1Sqn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fbxl3Afh/Fbxl3+
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Rassf1tm1Gpp/Rassf1+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Tnks2tm1.1Susm/Tnks2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002799 abnormal passive avoidance behavior "defects in the ability of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously with prolonged latency" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Fbxl3Afh/Fbxl3+
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH

 MP:0003194 abnormal frequency of paradoxical sleep "abnormal incidence or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Gja10tm1Kwi/Gja10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mchr1tm1Sqn/Mchr1tm1Sqn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Mchr1tm1Sqn/Mchr1tm1Sqn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mchr1tm1Sqn/Mchr1tm1Sqn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005322 abnormal serotonin level "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005450 abnormal energy expenditure "utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rassf1tm1Gpp/Rassf1+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

Allelic Composition: Mchr1tm1Yush/Mchr1tm1Yush
Genetic Background: involves: 129 * C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Mchr1tm1Sqn/Mchr1tm1Sqn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005471 decreased thyroxine level "less than the normal concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:13923]
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Allelic Composition: Mchr1tm1Sqn/Mchr1tm1Sqn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005533 increased body temperature "greater than the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Rassf1tm1Gpp/Rassf1+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

Allelic Composition: Mchr1tm1Blak/Mchr1tm1Blak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Mchr1tm1Yush/Mchr1tm1Yush
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Mchr1tm1Sqn/Mchr1tm1Sqn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Mchr1tm1Yush/Mchr1tm1Yush
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Mchr1tm1Sqn/Mchr1tm1Sqn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mchr1tm1Yush/Mchr1tm1Yush
Genetic Background: involves: 129 * C57BL/6

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja10tm1Kwi/Gja10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rassf1tm1Gpp/Rassf1+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

Allelic Composition: Mchr1tm1Yush/Mchr1tm1Yush
Genetic Background: involves: 129 * C57BL/6

 MP:0010167 decreased response to stress-induced hyperthermia "reduction or absence of the expected increase in core body termperature in response to stress or anticipatory anxiety" [PMID:18722480]
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Allelic Composition: Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mchr1tm1Sqn/Mchr1tm1Sqn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011020 abnormal circadian temperature homeostasis "any anomaly in the process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours" [GO:0060086]
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Allelic Composition: Rassf1tm1Gpp/Rassf1+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Mchr1tm1Yush/Mchr1tm1Yush
Genetic Background: involves: 129 * C57BL/6

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Mchr1tm1Sqn/Mchr1tm1Sqn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000035383 Pmch / P56942 / pro-melanin-concentrating hormone / P20382*  / reaction / complex






 

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