ENSMUSG00000035431


Mus musculus

Features
Gene ID: ENSMUSG00000035431
  
Biological name :Sstr1
  
Synonyms : P30873 / somatostatin receptor 1 / Sstr1
  
Possible biological names infered from orthology : P30872
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: C1
Gene start: 58211772
Gene end: 58214444
  
Corresponding Affymetrix probe sets: 10395889 (MoGene1.0st)   1450527_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037045
Ensembl peptide - ENSMUSP00000106299
NCBI entrez gene - 20605     See in Manteia.
MGI - MGI:98327
RefSeq - XM_006515634
RefSeq - NM_009216
RefSeq Peptide - NP_033242
swissprot - P30873
swissprot - Q543T0
Ensembl - ENSMUSG00000035431
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sstr1aENSDARG00000104922Danio rerio
 SSTR1ENSGALG00000010139Gallus gallus
 SSTR1ENSG00000139874Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sstr4 / somatostatin receptor 4 / P31391*ENSMUSG0000003701457
Sstr2 / P30875 / Somatostatin receptor type 2 / P30874* / somatostatin receptor 2*ENSMUSG0000004790443
Sstr3 / P30935 / Somatostatin receptor type 3 / P32745* / somatostatin receptor 3*ENSMUSG0000004493342
Sstr5 / O08858 / Somatostatin receptor type 5 / P35346* / somatostatin receptor 5*ENSMUSG0000005082442
Oprd1 / P32300 / opioid receptor, delta 1 / P41143*ENSMUSG0000005051135
Oprm1 / P42866 / opioid receptor, mu 1 / P35372*ENSMUSG0000000076634
Oprl1 / P35377 / opioid receptor-like 1 / P41146* / opioid related nociceptin receptor 1*ENSMUSG0000002758432
Oprk1 / P33534 / Kappa-type opioid receptor / P41145* / opioid receptor kappa 1*ENSMUSG0000002590532
Npbwr1 / P49681 / Neuropeptides B/W receptor type 1 / P48145* / neuropeptides B and W receptor 1*ENSMUSG0000003377430
Mchr1 / Q8JZL2 / Melanin-concentrating hormone receptor 1 / Q99705*ENSMUSG0000005016426


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000586  Somatostatin receptor family
 IPR001116  Somatostatin receptor 1
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IMP
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
 biological_processGO:0007215 glutamate receptor signaling pathway IDA
 biological_processGO:0007218 neuropeptide signaling pathway IDA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008285 negative regulation of cell proliferation IBA
 biological_processGO:0021549 cerebellum development IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0038170 somatostatin signaling pathway IEA
 biological_processGO:0042594 response to starvation IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004994 somatostatin receptor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042923 neuropeptide binding IBA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: C3ar1tm1Raw/C3ar1tm1Raw
Genetic Background: B6.129X1(B6)-C3ar1tm1Raw

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: C3ar1tm1Raw/C3ar1tm1Raw
Genetic Background: B6.129X1(B6)-C3ar1tm1Raw

 MP:0004495 decreased synaptic glutamate release "reduced secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata1tm8.2Sho/Gata1tm8.2Sho
Genetic Background: involves: 129S1/Sv

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bbs4Gt1Nk/Bbs4Gt1Nk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: C3ar1tm1Raw/C3ar1tm1Raw
Genetic Background: B6.129X1(B6)-C3ar1tm1Raw

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Bbs4Gt1Nk/Bbs4Gt1Nk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0006072 abnormal retinal apoptosis "increase or decrease in the number of cells in the retina undergoing programmed cell death" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92622:]
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Allelic Composition: Gata1tm8.2Sho/Gata1tm8.2Sho
Genetic Background: involves: 129S1/Sv

 MP:0006074 abnormal retinal rod bipolar cell morphology "anomalous structure of the bipolar cells that function in low light and transmit signals only through amacrine cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623]
Show

Allelic Composition: Bbs4Gt1Nk/Bbs4Gt1Nk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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