ENSMUSG00000025905


Mus musculus

Features
Gene ID: ENSMUSG00000025905
  
Biological name :Oprk1
  
Synonyms : Kappa-type opioid receptor / Oprk1 / P33534
  
Possible biological names infered from orthology : opioid receptor kappa 1 / P41145
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: A1
Gene start: 5588466
Gene end: 5606131
  
Corresponding Affymetrix probe sets: 10344653 (MoGene1.0st)   1446394_at (Mouse Genome 430 2.0 Array)   1451813_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027038
Ensembl peptide - ENSMUSP00000124030
Ensembl peptide - ENSMUSP00000125105
NCBI entrez gene - 18387     See in Manteia.
MGI - MGI:97439
RefSeq - XM_006495470
RefSeq - NM_001204371
RefSeq - NM_001318735
RefSeq - NM_011011
RefSeq Peptide - NP_001305664
RefSeq Peptide - NP_035141
RefSeq Peptide - NP_001191300
swissprot - P33534
swissprot - Q14AL5
Ensembl - ENSMUSG00000025905
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 oprk1ENSDARG00000006894Danio rerio
 OPRK1ENSGALG00000015269Gallus gallus
 OPRK1ENSG00000082556Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Oprm1 / P42866 / opioid receptor, mu 1 / P35372*ENSMUSG0000000076657
Oprd1 / P32300 / opioid receptor, delta 1 / P41143*ENSMUSG0000005051156
Oprl1 / P35377 / opioid receptor-like 1 / P41146* / opioid related nociceptin receptor 1*ENSMUSG0000002758451
Sstr4 / somatostatin receptor 4 / P31391*ENSMUSG0000003701434
Sstr2 / P30875 / Somatostatin receptor type 2 / P30874* / somatostatin receptor 2*ENSMUSG0000004790433
Sstr1 / P30873 / somatostatin receptor 1 / P30872*ENSMUSG0000003543133
Sstr5 / O08858 / Somatostatin receptor type 5 / P35346* / somatostatin receptor 5*ENSMUSG0000005082432
Sstr3 / P30935 / Somatostatin receptor type 3 / P32745* / somatostatin receptor 3*ENSMUSG0000004493332
Npbwr1 / P49681 / Neuropeptides B/W receptor type 1 / P48145* / neuropeptides B and W receptor 1*ENSMUSG0000003377430
Mchr1 / Q8JZL2 / Melanin-concentrating hormone receptor 1 / Q99705*ENSMUSG0000005016422


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000452  Kappa opioid receptor
 IPR001418  Opioid receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response ISO
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007218 neuropeptide signaling pathway IBA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007610 behavior IEA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0031635 adenylate cyclase-inhibiting opioid receptor signaling pathway ISO
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0033603 positive regulation of dopamine secretion IEA
 biological_processGO:0033685 negative regulation of luteinizing hormone secretion IEA
 biological_processGO:0038003 opioid receptor signaling pathway ISO
 biological_processGO:0040017 positive regulation of locomotion IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042711 maternal behavior IEA
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0044849 estrous cycle IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0046877 regulation of saliva secretion IMP
 biological_processGO:0048148 behavioral response to cocaine IEA
 biological_processGO:0050951 sensory perception of temperature stimulus IEA
 biological_processGO:0051607 defense response to virus ISO
 biological_processGO:0051930 regulation of sensory perception of pain IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:1900745 positive regulation of p38MAPK cascade IEA
 biological_processGO:1901381 positive regulation of potassium ion transmembrane transport IEA
 biological_processGO:1903715 regulation of aerobic respiration IEA
 biological_processGO:1903937 response to acrylamide IEA
 biological_processGO:1990708 conditioned place preference IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISO
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043005 neuron projection IBA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004985 opioid receptor activity ISS
 molecular_functionGO:0038048 dynorphin receptor activity ISO
 molecular_functionGO:0042923 neuropeptide binding IBA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000623 reduced salivation "decrease flow, secretion, or amount of saliva" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkacatm2Gsm/Prkacatm2Gsm
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
Show

Allelic Composition: Lrit3tvrm257/Lrit3tvrm257
Genetic Background: B6.Cg-Lrit3tvrm257/Pjn

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkacatm2Gsm/Prkacatm2Gsm
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001462 abnormal avoidance learning behavior "defects in the ability to associate a previously neutral stimulus with an unpleasant or punishing stimuli so that the animal learns to avoid the previously neutral stimulus" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+,Ihhtm1Amc/Ihhtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001934 increased litter size "greater numbers of live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkacatm2Gsm/Prkacatm2Gsm
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
Show

Allelic Composition: Prkacatm2Gsm/Prkacatm2Gsm
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001980 abnormal chemically-elicited antinociception "change in the analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oprk1tm2.1Kff/Oprk1tm2.1Kff,Tg(Fev-cre)1Esd/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001982 reduced chemically-elicited antinociception "less than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mirc30tm1.1Rdf/Mirc30tm1.1Rdf
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Oprk1tm1.2Waca/Oprk1tm1.2Waca
Genetic Background: B6J.B6NTac(Cg)-Oprk1tm1.2Waca

 MP:0002062 abnormal conditioning behavior "inability to change the frequency or form of a behavior as a result of the influence of the environment " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp26b1tm1Hh/Cyp26b1tm1Hh,Tg(Prox1-EGFP)KY221Gsat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NTac

Allelic Composition: Oprk1tm2.1Kff/Oprk1tm2.1Kff,Tg(Fev-cre)1Esd/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oprk1tm2.1Kff/Oprk1tm2.1Kff,Tg(Fev-cre)1Esd/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0009754 enhanced behavioral response to cocaine "increased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lrit3tvrm257/Lrit3tvrm257
Genetic Background: B6.Cg-Lrit3tvrm257/Pjn

 MP:0009757 impaired behavioral response to morphine "decreased sensitivity to morphine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkacatm2Gsm/Prkacatm2Gsm
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009778 impaired behavioral response to anesthetic "decrease or delay in the behavioral changes that follow exposure to a given amount of an anesthetizing agent" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clcn5tm1Tjj/Clcn5+,Clcn7tm3.1Tjj/Clcn7tm3.1Tjj,Tg(APOE-cre)VITew/0
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0010149 abnormal synaptic dopamine release "aberrant secretion across synapses of the catecholamine neurotransmitter and neurohormone, derived from tyrosine and the precursor to norepinephrine and epinephrine; functions as a neurotransmitter in the brain and as a hormone to inhibit the release of prolactin from the anterior lobe of the pituitary" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyp26b1tm1Hh/Cyp26b1tm1Hh,Tg(Prox1-EGFP)KY221Gsat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NTac

Allelic Composition: Oprk1tm1Jep/Oprk1tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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