ENSMUSG00000047904


Mus musculus

Features
Gene ID: ENSMUSG00000047904
  
Biological name :Sstr2
  
Synonyms : P30875 / Somatostatin receptor type 2 / Sstr2
  
Possible biological names infered from orthology : P30874 / somatostatin receptor 2
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E2
Gene start: 113619342
Gene end: 113626028
  
Corresponding Affymetrix probe sets: 10382341 (MoGene1.0st)   1422256_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000068578
Ensembl peptide - ENSMUSP00000102241
Ensembl peptide - ENSMUSP00000138101
NCBI entrez gene - 20606     See in Manteia.
MGI - MGI:98328
RefSeq - NM_001042606
RefSeq - NM_009217
RefSeq Peptide - NP_001036071
RefSeq Peptide - NP_033243
swissprot - P30875
Ensembl - ENSMUSG00000047904
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sstr2aENSDARG00000059090Danio rerio
 sstr2bENSDARG00000069806Danio rerio
 SSTR2ENSGALG00000004418Gallus gallus
 SSTR2ENSG00000180616Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sstr5 / O08858 / Somatostatin receptor type 5 / P35346* / somatostatin receptor 5*ENSMUSG0000005082451
Sstr3 / P30935 / Somatostatin receptor type 3 / P32745* / somatostatin receptor 3*ENSMUSG0000004493347
Sstr1 / P30873 / somatostatin receptor 1 / P30872*ENSMUSG0000003543146
Sstr4 / somatostatin receptor 4 / P31391*ENSMUSG0000003701445
Oprm1 / P42866 / opioid receptor, mu 1 / P35372*ENSMUSG0000000076637
Oprd1 / P32300 / opioid receptor, delta 1 / P41143*ENSMUSG0000005051135
Oprk1 / P33534 / Kappa-type opioid receptor / P41145* / opioid receptor kappa 1*ENSMUSG0000002590534
Oprl1 / P35377 / opioid receptor-like 1 / P41146* / opioid related nociceptin receptor 1*ENSMUSG0000002758433
Npbwr1 / P49681 / Neuropeptides B/W receptor type 1 / P48145* / neuropeptides B and W receptor 1*ENSMUSG0000003377431
Mchr1 / Q8JZL2 / Melanin-concentrating hormone receptor 1 / Q99705*ENSMUSG0000005016429


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000586  Somatostatin receptor family
 IPR002074  Somatostatin receptor 2
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006937 regulation of muscle contraction IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IMP
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007218 neuropeptide signaling pathway IDA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008285 negative regulation of cell proliferation IBA
 biological_processGO:0021549 cerebellum development IEA
 biological_processGO:0030432 peristalsis IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0038170 somatostatin signaling pathway IEA
 biological_processGO:0042594 response to starvation IEA
 biological_processGO:0071385 cellular response to glucocorticoid stimulus IBA
 biological_processGO:0071392 cellular response to estradiol stimulus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004994 somatostatin receptor activity IMP
 molecular_functionGO:0030165 PDZ domain binding ISO
 molecular_functionGO:0042923 neuropeptide binding IBA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Sstr2tm1Pce/Sstr2tm1Pce
Genetic Background: B6.129P2-Sstr2tm1Pce

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Sstr2tm1Pce/Sstr2tm1Pce
Genetic Background: B6.129P2-Sstr2tm1Pce

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Robo2tm1.1Rilm/Robo2+,Tg(Hoxb7-EGFP)33Cos/?
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Sstr2tm1Pce/Sstr2tm1Pce
Genetic Background: B6.129P2-Sstr2tm1Pce

 MP:0001748 increased circulating adrenocorticotropin level "elevated concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
Show

Allelic Composition: Sstr2tm1Pce/Sstr2tm1Pce
Genetic Background: B6.129P2-Sstr2tm1Pce

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sstr2tm1Pce/Sstr2tm1Pce
Genetic Background: B6.129P2-Sstr2tm1Pce

 MP:0003038 decreased infarction size "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Robo2tm1.1Rilm/Robo2+,Tg(Hoxb7-EGFP)33Cos/?
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N

 MP:0004494 abnormal synaptic glutamate release "aberrant secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sstr2tm1Pce/Sstr2tm1Pce
Genetic Background: B6.129P2-Sstr2tm1Pce

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sstr2tm1Pce/Sstr2tm1Pce
Genetic Background: B6.129P2-Sstr2tm1Pce

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sstr2tm1Pce/Sstr2tm1Pce
Genetic Background: B6.129P2-Sstr2tm1Pce

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
Show

Allelic Composition: Robo2tm1.1Rilm/Robo2+,Tg(Hoxb7-EGFP)33Cos/?
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N

 MP:0006074 abnormal retinal rod bipolar cell morphology "anomalous structure of the bipolar cells that function in low light and transmit signals only through amacrine cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623]
Show

Allelic Composition: Gata1tm8.2Sho/Gata1tm8.2Sho
Genetic Background: involves: 129S1/Sv

Allelic Composition: Sstr2tm1Pce/Sstr2tm1Pce
Genetic Background: B6.129P2-Sstr2tm1Pce

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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