ENSMUSG00000050824


Mus musculus

Features
Gene ID: ENSMUSG00000050824
  
Biological name :Sstr5
  
Synonyms : O08858 / Somatostatin receptor type 5 / Sstr5
  
Possible biological names infered from orthology : P35346 / somatostatin receptor 5
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 25489875
Gene end: 25497288
  
Corresponding Affymetrix probe sets: 10448963 (MoGene1.0st)   1445459_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000051085
Ensembl peptide - ENSMUSP00000128787
NCBI entrez gene - 20609     See in Manteia.
MGI - MGI:894282
RefSeq - NM_001191008
RefSeq - NM_011425
RefSeq Peptide - NP_001177937
RefSeq Peptide - NP_035555
swissprot - O08858
Ensembl - ENSMUSG00000050824
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sstr5ENSDARG00000101655Danio rerio
 SSTR5ENSGALG00000005258Gallus gallus
 SSTR5ENSG00000162009Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sstr3 / P30935 / Somatostatin receptor type 3 / P32745* / somatostatin receptor 3*ENSMUSG0000004493356
Sstr2 / P30875 / Somatostatin receptor type 2 / P30874* / somatostatin receptor 2*ENSMUSG0000004790452
Sstr4 / somatostatin receptor 4 / P31391*ENSMUSG0000003701449
Sstr1 / P30873 / somatostatin receptor 1 / P30872*ENSMUSG0000003543146
Npbwr1 / P49681 / Neuropeptides B/W receptor type 1 / P48145* / neuropeptides B and W receptor 1*ENSMUSG0000003377436
Oprd1 / P32300 / opioid receptor, delta 1 / P41143*ENSMUSG0000005051135
Oprm1 / P42866 / opioid receptor, mu 1 / P35372*ENSMUSG0000000076635
Oprl1 / P35377 / opioid receptor-like 1 / P41146* / opioid related nociceptin receptor 1*ENSMUSG0000002758435
Oprk1 / P33534 / Kappa-type opioid receptor / P41145* / opioid receptor kappa 1*ENSMUSG0000002590533
Mchr1 / Q8JZL2 / Melanin-concentrating hormone receptor 1 / Q99705*ENSMUSG0000005016428


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000586  Somatostatin receptor family
 IPR001184  Somatostatin receptor 5
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0008285 negative regulation of cell proliferation IBA
 biological_processGO:0032467 positive regulation of cytokinesis IEA
 biological_processGO:0038170 somatostatin signaling pathway IEA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0050796 regulation of insulin secretion IMP
 biological_processGO:0071385 cellular response to glucocorticoid stimulus IBA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004994 somatostatin receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042923 neuropeptide binding IBA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Igfalstm1Yrb/Igfalstm1Yrb,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Igfalstm1Yrb/Igfalstm1Yrb,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0002712 increased circulating glucagon level "greater than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Igfalstm1Yrb/Igfalstm1Yrb,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Igfalstm1Yrb/Igfalstm1Yrb,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Igfalstm1Yrb/Igfalstm1Yrb,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Igfalstm1Yrb/Igfalstm1Yrb,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

Allelic Composition: Sstr5tm1Fcb/Sstr5tm2Fcb,Tg(Ins2-cre)1Heed/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Sstr5tm1Fcb/Sstr5tm1Fcb
Genetic Background: involves: 129

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Sstr5tm1Fcb/Sstr5tm2Fcb,Tg(Ins2-cre)1Heed/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Abcc8tm1Jbry/Abcc8tm1Jbry,Sstr5tm1Fcb/Sstr5tm1Fcb
Genetic Background: involves: 129X1/SvJ

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Daxxtm1Maul/Daxxtm1Maul
Genetic Background: involves: 129/Sv

 MP:0003564 abnormal insulin secretion "aberrant release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcc8tm1Jbry/Abcc8tm1Jbry,Sstr5tm1Fcb/Sstr5tm1Fcb
Genetic Background: involves: 129X1/SvJ

 MP:0003839 abnormal insulin clearance "increase or decrease in the rate at which insulin is removed from the blood stream" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:99786]
Show

Allelic Composition: Sstr5tm1Fcb/Sstr5tm2Fcb,Tg(Ins2-cre)1Heed/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0005216 abnormal pancreatic alpha cell morphology "malformation of the cells of the pancreas that secrete glucagon" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lmf1cld/Lmf1cld
Genetic Background: Not Specified

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Igfalstm1Yrb/Igfalstm1Yrb,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Igfalstm1Yrb/Igfalstm1Yrb,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Abcc8tm1Jbry/Abcc8tm1Jbry,Sstr5tm1Fcb/Sstr5tm1Fcb
Genetic Background: involves: 129X1/SvJ

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Igfalstm1Yrb/Igfalstm1Yrb,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

Allelic Composition: Sstr5tm1Fcb/Sstr5tm2Fcb,Tg(Ins2-cre)1Heed/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Abcc8tm1Jbry/Abcc8tm1Jbry,Sstr5tm1Fcb/Sstr5tm1Fcb
Genetic Background: involves: 129X1/SvJ

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Igfalstm1Yrb/Igfalstm1Yrb,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0009181 decreased pancreatic delta cell number "reduced number of the cells found in the pancreas that secrete somatostatin" [MESH:A03.556.875.875.440.854]
Show

Allelic Composition: Sstr5tm1Fcb/Sstr5tm2Fcb,Tg(Ins2-cre)1Heed/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr