ENSMUSG00000027584


Mus musculus

Features
Gene ID: ENSMUSG00000027584
  
Biological name :Oprl1
  
Synonyms : opioid receptor-like 1 / Oprl1 / P35377
  
Possible biological names infered from orthology : opioid related nociceptin receptor 1 / P41146
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H4
Gene start: 181715016
Gene end: 181720985
  
Corresponding Affymetrix probe sets: 10479685 (MoGene1.0st)   1422099_a_at (Mouse Genome 430 2.0 Array)   1426204_a_at (Mouse Genome 430 2.0 Array)   1450486_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138979
Ensembl peptide - ENSMUSP00000138810
Ensembl peptide - ENSMUSP00000139119
Ensembl peptide - ENSMUSP00000071513
Ensembl peptide - ENSMUSP00000104394
Ensembl peptide - ENSMUSP00000104397
Ensembl peptide - ENSMUSP00000104398
Ensembl peptide - ENSMUSP00000104399
Ensembl peptide - ENSMUSP00000118664
NCBI entrez gene - 18389     See in Manteia.
MGI - MGI:97440
RefSeq - XM_017316330
RefSeq - NM_001318920
RefSeq - NM_001318922
RefSeq - NM_001318923
RefSeq - NM_001318924
RefSeq - NM_001318925
RefSeq - NM_011012
RefSeq - XM_006500582
RefSeq - XM_006500584
RefSeq - XM_017316323
RefSeq - XM_017316325
RefSeq - XM_017316326
RefSeq - XM_017316328
RefSeq - XM_017316329
RefSeq - NM_001252565
RefSeq - NM_001318919
RefSeq Peptide - NP_035142
RefSeq Peptide - NP_001239494
RefSeq Peptide - NP_001305848
RefSeq Peptide - NP_001305849
RefSeq Peptide - NP_001305851
RefSeq Peptide - NP_001305852
RefSeq Peptide - NP_001305853
RefSeq Peptide - NP_001305854
swissprot - Q542U1
swissprot - P35377
swissprot - B0R0C0
swissprot - V9GX47
swissprot - B0R0B7
Ensembl - ENSMUSG00000027584
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 oprl1ENSDARG00000071209Danio rerio
 OPRL1ENSGALG00000027965Gallus gallus
 OPRL1ENSG00000125510Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Oprk1 / P33534 / Kappa-type opioid receptor / P41145* / opioid receptor kappa 1*ENSMUSG0000002590552
Oprm1 / P42866 / opioid receptor, mu 1 / P35372*ENSMUSG0000000076651
Oprd1 / P32300 / opioid receptor, delta 1 / P41143*ENSMUSG0000005051151
Sstr5 / O08858 / Somatostatin receptor type 5 / P35346* / somatostatin receptor 5*ENSMUSG0000005082435
Sstr4 / somatostatin receptor 4 / P31391*ENSMUSG0000003701435
Sstr3 / P30935 / Somatostatin receptor type 3 / P32745* / somatostatin receptor 3*ENSMUSG0000004493335
Sstr1 / P30873 / somatostatin receptor 1 / P30872*ENSMUSG0000003543134
Sstr2 / P30875 / Somatostatin receptor type 2 / P30874* / somatostatin receptor 2*ENSMUSG0000004790433
Npbwr1 / P49681 / Neuropeptides B/W receptor type 1 / P48145* / neuropeptides B and W receptor 1*ENSMUSG0000003377432
Mchr1 / Q8JZL2 / Melanin-concentrating hormone receptor 1 / Q99705*ENSMUSG0000005016425


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001418  Opioid receptor
 IPR001420  X opioid receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISO
 biological_processGO:0007218 neuropeptide signaling pathway IBA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007610 behavior IEA
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0035810 positive regulation of urine volume IEA
 biological_processGO:0038003 opioid receptor signaling pathway IEA
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0043951 negative regulation of cAMP-mediated signaling IEA
 biological_processGO:0044849 estrous cycle IEA
 biological_processGO:0045776 negative regulation of blood pressure IEA
 biological_processGO:0051930 regulation of sensory perception of pain IEA
 biological_processGO:0060454 positive regulation of gastric acid secretion IEA
 biological_processGO:0106072 negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:1901386 negative regulation of voltage-gated calcium channel activity IEA
 biological_processGO:1904058 positive regulation of sensory perception of pain IEA
 biological_processGO:1904059 regulation of locomotor rhythm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043005 neuron projection IBA
 molecular_functionGO:0001626 nociceptin receptor activity ISO
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity ISO
 molecular_functionGO:0004985 opioid receptor activity IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0042923 neuropeptide binding IBA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001968 abnormal touch/ nociception "change in the ability to sense contact with objects or in the ability to sense pain, most often registered by mechanoreceptors in the skin and mucous membranes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001982 reduced chemically-elicited antinociception "less than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002734 abnormal mechanical nociception "abnormal capability to sense pain elicited by mechanical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fancgtm1Ada/Fancgtm1Ada
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002735 abnormal chemical nociception "abnormal capability to sense pain elicited by chemical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002799 abnormal passive avoidance behavior "defects in the ability of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously with prolonged latency" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
Show

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004597 increased susceptibility to noise-induced hearing loss "greater than normal reduction in hearing sensitivity following exposure to acute noise that is injurious to the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009757 impaired behavioral response to morphine "decreased sensitivity to morphine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000045731 Pnoc / Q64387 / prepronociceptin / Q13519*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr