ENSMUSG00000050511


Mus musculus

Features
Gene ID: ENSMUSG00000050511
  
Biological name :Oprd1
  
Synonyms : opioid receptor, delta 1 / Oprd1 / P32300
  
Possible biological names infered from orthology : P41143
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.3
Gene start: 132110726
Gene end: 132144486
  
Corresponding Affymetrix probe sets: 10516852 (MoGene1.0st)   1422121_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050077
NCBI entrez gene - 18386     See in Manteia.
MGI - MGI:97438
RefSeq - NM_013622
RefSeq Peptide - NP_038650
swissprot - A2AD37
swissprot - P32300
Ensembl - ENSMUSG00000050511
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 oprd1aENSDARG00000041660Danio rerio
 oprd1bENSDARG00000037159Danio rerio
 ENSGALG00000036782Gallus gallus
 OPRD1ENSG00000116329Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Oprm1 / P42866 / opioid receptor, mu 1 / P35372*ENSMUSG0000000076660
Oprk1 / P33534 / Kappa-type opioid receptor / P41145* / opioid receptor kappa 1*ENSMUSG0000002590557
Oprl1 / P35377 / opioid receptor-like 1 / P41146* / opioid related nociceptin receptor 1*ENSMUSG0000002758451
Sstr4 / somatostatin receptor 4 / P31391*ENSMUSG0000003701437
Sstr1 / P30873 / somatostatin receptor 1 / P30872*ENSMUSG0000003543136
Sstr3 / P30935 / Somatostatin receptor type 3 / P32745* / somatostatin receptor 3*ENSMUSG0000004493335
Sstr5 / O08858 / Somatostatin receptor type 5 / P35346* / somatostatin receptor 5*ENSMUSG0000005082434
Sstr2 / P30875 / Somatostatin receptor type 2 / P30874* / somatostatin receptor 2*ENSMUSG0000004790434
Npbwr1 / P49681 / Neuropeptides B/W receptor type 1 / P48145* / neuropeptides B and W receptor 1*ENSMUSG0000003377430
Mchr1 / Q8JZL2 / Melanin-concentrating hormone receptor 1 / Q99705*ENSMUSG0000005016425


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000321  Delta opioid receptor
 IPR001418  Opioid receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation ISO
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007218 neuropeptide signaling pathway IDA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0019233 sensory perception of pain IBA
 biological_processGO:0032460 negative regulation of protein oligomerization ISO
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0038003 opioid receptor signaling pathway ISO
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0051881 regulation of mitochondrial membrane potential ISO
 biological_processGO:0051924 regulation of calcium ion transport IEA
 biological_processGO:0051930 regulation of sensory perception of pain IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0071456 cellular response to hypoxia ISO
 biological_processGO:0097237 cellular response to toxic substance ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IDA
 cellular_componentGO:0031226 intrinsic component of plasma membrane ISO
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0032590 dendrite membrane IEA
 cellular_componentGO:0043005 neuron projection IBA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004985 opioid receptor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0038046 enkephalin receptor activity ISO
 molecular_functionGO:0042923 neuropeptide binding IBA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001980 abnormal chemically-elicited antinociception "change in the analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(Ins2-CD80)3B7Flv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Oprm1tm1.2Cgrf/Oprm1tm1.2Cgrf
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003064 decreased coping response "reduced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]
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Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lcattm1Hgc/Lcattm1Hgc
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprd1tm1.1Cgrf/Oprd1tm1.1Cgrf,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Oprd1tm1.2Cgrf/Oprd1tm1.2Cgrf
Genetic Background: involves: 129 * C57BL/6J

 MP:0009748 abnormal behavioral response to addictive substance "any anomaly in the behavioral response induced by an addictive substance, such as induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(Ins2-CD80)3B7Flv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0009757 impaired behavioral response to morphine "decreased sensitivity to morphine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lcattm1Hgc/Lcattm1Hgc
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0009778 impaired behavioral response to anesthetic "decrease or delay in the behavioral changes that follow exposure to a given amount of an anesthetizing agent" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprd1tm1Jep/Oprd1tm1Jep,Oprm1tm1Jep/Oprm1tm1Jep,Oprm1tm1Jep/Oprm1tm1Jep
Genetic Background: involves: 129S/SvEv * 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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