ENSG00000082556


Homo sapiens

Features
Gene ID: ENSG00000082556
  
Biological name :OPRK1
  
Synonyms : opioid receptor kappa 1 / OPRK1 / P41145
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q11.23
Gene start: 53225716
Gene end: 53251697
  
Corresponding Affymetrix probe sets: 207553_at (Human Genome U133 Plus 2.0 Array)   229944_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000478453
Ensembl peptide - ENSP00000429706
Ensembl peptide - ENSP00000483000
Ensembl peptide - ENSP00000430923
Ensembl peptide - ENSP00000265572
Ensembl peptide - ENSP00000428231
NCBI entrez gene - 4986     See in Manteia.
OMIM - 165196
RefSeq - NM_000912
RefSeq - NM_001282904
RefSeq - NM_001318497
RefSeq Peptide - NP_001269833
RefSeq Peptide - NP_001305426
RefSeq Peptide - NP_000903
swissprot - P41145
swissprot - A0A087WU84
swissprot - E5RJI5
Ensembl - ENSG00000082556
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 oprk1ENSDARG00000006894Danio rerio
 OPRK1ENSGALG00000015269Gallus gallus
 Oprk1ENSMUSG00000025905Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
OPRM1 / P35372 / opioid receptor mu 1ENSG0000011203858
OPRD1 / P41143 / opioid receptor delta 1ENSG0000011632956
OPRL1 / P41146 / opioid related nociceptin receptor 1ENSG0000012551052
SSTR4 / P31391 / somatostatin receptor 4ENSG0000013267135
SSTR3 / P32745 / somatostatin receptor 3ENSG0000027819534
SSTR1 / P30872 / somatostatin receptor 1ENSG0000013987434
SSTR2 / P30874 / somatostatin receptor 2ENSG0000018061633
NPBWR2 / P48146 / neuropeptides B and W receptor 2ENSG0000012552232
SSTR5 / P35346 / somatostatin receptor 5ENSG0000016200931
NPBWR1 / P48145 / neuropeptides B and W receptor 1ENSG0000018372929
MCHR2 / Q969V1 / melanin concentrating hormone receptor 2ENSG0000015203427
MCHR1 / Q99705 / melanin concentrating hormone receptor 1ENSG0000012828523


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000452  Kappa opioid receptor
 IPR001418  Opioid receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007218 neuropeptide signaling pathway IBA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007600 sensory perception TAS
 biological_processGO:0007610 behavior IEA
 biological_processGO:0007626 locomotory behavior ISS
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0019233 sensory perception of pain IBA
 biological_processGO:0031635 adenylate cyclase-inhibiting opioid receptor signaling pathway IDA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0033603 positive regulation of dopamine secretion IEA
 biological_processGO:0033685 negative regulation of luteinizing hormone secretion IEA
 biological_processGO:0038003 opioid receptor signaling pathway IEA
 biological_processGO:0040017 positive regulation of locomotion IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042711 maternal behavior IEA
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0044849 estrous cycle IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0046877 regulation of saliva secretion ISS
 biological_processGO:0048148 behavioral response to cocaine IEA
 biological_processGO:0050951 sensory perception of temperature stimulus IEA
 biological_processGO:0051607 defense response to virus IDA
 biological_processGO:0051930 regulation of sensory perception of pain IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:1900745 positive regulation of p38MAPK cascade IEA
 biological_processGO:1901381 positive regulation of potassium ion transmembrane transport IEA
 biological_processGO:1903715 regulation of aerobic respiration IEA
 biological_processGO:1903937 response to acrylamide IEA
 biological_processGO:1990708 conditioned place preference IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043005 neuron projection IBA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004985 opioid receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0038048 dynorphin receptor activity IEA
 molecular_functionGO:0042923 neuropeptide binding IBA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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