ENSMUSG00000035383


Mus musculus

Features
Gene ID: ENSMUSG00000035383
  
Biological name :Pmch
  
Synonyms : P56942 / Pmch / pro-melanin-concentrating hormone
  
Possible biological names infered from orthology : P20382
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 88091072
Gene end: 88092375
  
Corresponding Affymetrix probe sets: 10365574 (MoGene1.0st)   1429361_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044352
NCBI entrez gene - 110312     See in Manteia.
MGI - MGI:97629
RefSeq - NM_029971
RefSeq Peptide - NP_084247
swissprot - P56942
Ensembl - ENSMUSG00000035383
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PMCHENSGALG00000012757Gallus gallus
 PMCHENSG00000183395Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005456  Pre-pro melanin-concentrating hormone


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0007631 feeding behavior IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0005102 signaling receptor binding NAS
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0030354 melanin-concentrating hormone activity NAS


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Lepob/Lepob,Pmchtm1Emf/Pmchtm1Emf
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Pomctm1Sora/Pomctm1Sora
Genetic Background: involves: 129S2/SvHsd * 129S6/SvEvTac

Allelic Composition: Lepob/Lepob,Pmchtm1.1(DTR)Rpa/Pmch+
Genetic Background: B6.Cg-Lepob Pmchtm1.1(DTR)Rpa

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Lepob/Lepob,Pmchtm1Emf/Pmchtm1Emf
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001731 abnormal postnatal growth "anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob,Pmchtm1.1(DTR)Rpa/Pmch+
Genetic Background: B6.Cg-Lepob Pmchtm1.1(DTR)Rpa

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Lepob/Lepob,Pmchtm1.1(DTR)Rpa/Pmch+
Genetic Background: B6.Cg-Lepob Pmchtm1.1(DTR)Rpa

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Lepob/Lepob,Pmchtm1.1(DTR)Rpa/Pmch+
Genetic Background: B6.Cg-Lepob Pmchtm1.1(DTR)Rpa

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pomctm1Sora/Pomctm1Sora
Genetic Background: involves: 129S2/SvHsd * 129S6/SvEvTac

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob,Pmchtm1Emf/Pmchtm1Emf
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob,Pmchtm1Emf/Pmchtm1Emf
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pomctm1Sora/Pomctm1Sora
Genetic Background: involves: 129S2/SvHsd * 129S6/SvEvTac

Allelic Composition: Lepob/Lepob,Pmchtm1Emf/Pmchtm1Emf
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005291 abnormal glucose tolerance "deviation from the normal response to oral consumption or intravenous injection of specified amounts of glucose; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lepob/Lepob,Pmchtm1Emf/Pmchtm1Emf
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lepob/Lepob,Pmchtm1.1(DTR)Rpa/Pmch+
Genetic Background: B6.Cg-Lepob Pmchtm1.1(DTR)Rpa

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pomctm1Sora/Pomctm1Sora
Genetic Background: involves: 129S2/SvHsd * 129S6/SvEvTac

 MP:0005345 abnormal circulating corticosterone level "anomalous blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lepob/Lepob,Pmchtm1Emf/Pmchtm1Emf
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005452 abnormal body fat amount "more or less than the normal total amount of connective tissue composed of fat cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lepob/Lepob,Pmchtm1Emf/Pmchtm1Emf
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lepob/Lepob,Pmchtm1Emf/Pmchtm1Emf
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Pomctm1Sora/Pomctm1Sora
Genetic Background: involves: 129S2/SvHsd * 129S6/SvEvTac

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Lepob/Lepob,Pmchtm1.1(DTR)Rpa/Pmch+
Genetic Background: B6.Cg-Lepob Pmchtm1.1(DTR)Rpa

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pomctm1Sora/Pomctm1Sora
Genetic Background: involves: 129S2/SvHsd * 129S6/SvEvTac

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Lepob/Lepob,Pmchtm1Emf/Pmchtm1Emf
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Lepob/Lepob,Pmchtm1Emf/Pmchtm1Emf
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Pomctm1Sora/Pomctm1Sora
Genetic Background: involves: 129S2/SvHsd * 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000050164 Mchr1 / Q8JZL2 / Melanin-concentrating hormone receptor 1 / Q99705*  / reaction / complex






 

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