ENSG00000168243


Homo sapiens

Features
Gene ID: ENSG00000168243
  
Biological name :GNG4
  
Synonyms : GNG4 / G protein subunit gamma 4 / P50150
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q42.3
Gene start: 235547687
Gene end: 235650754
  
Corresponding Affymetrix probe sets: 1555765_a_at (Human Genome U133 Plus 2.0 Array)   1555867_at (Human Genome U133 Plus 2.0 Array)   1566513_a_at (Human Genome U133 Plus 2.0 Array)   205184_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000482192
Ensembl peptide - ENSP00000355556
Ensembl peptide - ENSP00000355557
Ensembl peptide - ENSP00000375727
Ensembl peptide - ENSP00000398629
NCBI entrez gene - 2786     See in Manteia.
RefSeq - XM_011544167
RefSeq - NM_001098721
RefSeq - NM_001098722
RefSeq - NM_004485
RefSeq - XM_006711761
RefSeq Peptide - NP_001092192
RefSeq Peptide - NP_004476
RefSeq Peptide - NP_001092191
swissprot - P50150
swissprot - B1APZ0
Ensembl - ENSG00000168243
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GNG4ENSDARG00000111259Danio rerio
 GNG4ENSGALG00000010986Gallus gallus
 Gng4ENSMUSG00000021303Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GNG2 / P59768 / G protein subunit gamma 2ENSG0000018646973
GNG3 / P63215 / G protein subunit gamma 3ENSG0000016218869
GNG8 / Q9UK08 / G protein subunit gamma 8ENSG0000016741456
GNG7 / O60262 / G protein subunit gamma 7ENSG0000017653356
GNG12 / Q9UBI6 / G protein subunit gamma 12ENSG0000017238053
GNG10 / P50151 / G protein subunit gamma 10ENSG0000024261644
GNG5 / P63218 / G protein subunit gamma 5ENSG0000017402143
GNG14 / A0A1W2PPG7 / G protein subunit gamma 14ENSG0000028398043


Protein motifs (from Interpro)
Interpro ID Name
 IPR001770  G-protein, gamma subunit
 IPR015898  G-protein gamma-like domain
 IPR036284  G-protein gamma-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS
 biological_processGO:0030308 negative regulation of cell growth IMP
 biological_processGO:0071377 cellular response to glucagon stimulus TAS
 cellular_componentGO:0005834 heterotrimeric G-protein complex IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Activation of G protein gated Potassium channels
Glucagon signaling in metabolic regulation
G-protein activation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
ADP signalling through P2Y purinoceptor 12
G beta:gamma signalling through PI3Kgamma
Prostacyclin signalling through prostacyclin receptor
Adrenaline,noradrenaline inhibits insulin secretion
Ca2+ pathway
G alpha (q) signalling events
G alpha (12/13) signalling events
G beta:gamma signalling through PLC beta
G alpha (s) signalling events
ADP signalling through P2Y purinoceptor 1
G alpha (i) signalling events
G alpha (z) signalling events
Glucagon-type ligand receptors
Thromboxane signalling through TP receptor
Vasopressin regulates renal water homeostasis via Aquaporins
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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