ENSMUSG00000021303


Mus musculus

Features
Gene ID: ENSMUSG00000021303
  
Biological name :Gng4
  
Synonyms : Gng4 / guanine nucleotide binding protein (G protein), gamma 4 / P50153
  
Possible biological names infered from orthology : G protein subunit gamma 4 / P50150
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A1
Gene start: 13784059
Gene end: 13827896
  
Corresponding Affymetrix probe sets: 10403658 (MoGene1.0st)   1417943_at (Mouse Genome 430 2.0 Array)   1417944_at (Mouse Genome 430 2.0 Array)   1447669_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021734
NCBI entrez gene - 14706     See in Manteia.
MGI - MGI:102703
RefSeq - NM_010317
RefSeq - NM_001302997
RefSeq Peptide - NP_001289926
RefSeq Peptide - NP_034447
swissprot - P50153
Ensembl - ENSMUSG00000021303
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GNG4ENSDARG00000111259Danio rerio
 GNG4ENSGALG00000010986Gallus gallus
 GNG4ENSG00000168243Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*ENSMUSG0000004300472
Gng3 / P63216 / guanine nucleotide binding protein (G protein), gamma 3 / P63215* / G protein subunit gamma 3*ENSMUSG0000007165868
Gng8 / P63078 / guanine nucleotide binding protein (G protein), gamma 8 / Q9UK08* / G protein subunit gamma 8*ENSMUSG0000006359456
Gng7 / Q61016 / guanine nucleotide binding protein (G protein), gamma 7 / O60262* / G protein subunit gamma 7*ENSMUSG0000004824055
Gng12 / Q9DAS9 / guanine nucleotide binding protein (G protein), gamma 12 / Q9UBI6* / G protein subunit gamma 12*ENSMUSG0000003640252
Gm5741 / G protein subunit gamma 14 / GNG14* / A0A1W2PPG7*ENSMUSG0000009584548
Gng10 / Q9CXP8 / guanine nucleotide binding protein (G protein), gamma 10 / P50151* / G protein subunit gamma 10*ENSMUSG0000003860743
Gng5 / Q80SZ7 / guanine nucleotide binding protein (G protein), gamma 5 / P63218* / G protein subunit gamma 5*ENSMUSG0000006852341


Protein motifs (from Interpro)
Interpro ID Name
 IPR001770  G-protein, gamma subunit
 IPR015898  G-protein gamma-like domain
 IPR036284  G-protein gamma-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISA
 biological_processGO:0030308 negative regulation of cell growth IEA
 cellular_componentGO:0005834 heterotrimeric G-protein complex ISA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003924 GTPase activity ISA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA


Pathways (from Reactome)
Pathway description
Activation of G protein gated Potassium channels
Glucagon signaling in metabolic regulation
G-protein activation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
ADP signalling through P2Y purinoceptor 12
G beta:gamma signalling through PI3Kgamma
Prostacyclin signalling through prostacyclin receptor
Adrenaline,noradrenaline inhibits insulin secretion
Ca2+ pathway
G alpha (q) signalling events
G alpha (12/13) signalling events
G beta:gamma signalling through PLC beta
G alpha (s) signalling events
ADP signalling through P2Y purinoceptor 1
G alpha (i) signalling events
G alpha (z) signalling events
Glucagon-type ligand receptors
Thromboxane signalling through TP receptor
Vasopressin regulates renal water homeostasis via Aquaporins
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   


© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr