ENSMUSG00000063594


Mus musculus

Features
Gene ID: ENSMUSG00000063594
  
Biological name :Gng8
  
Synonyms : Gng8 / guanine nucleotide binding protein (G protein), gamma 8 / P63078
  
Possible biological names infered from orthology : G protein subunit gamma 8 / Q9UK08
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A2
Gene start: 16891786
Gene end: 16895436
  
Corresponding Affymetrix probe sets: 10550388 (MoGene1.0st)   1457755_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077314
Ensembl peptide - ENSMUSP00000145533
Ensembl peptide - ENSMUSP00000145567
NCBI entrez gene - 14709     See in Manteia.
MGI - MGI:109163
RefSeq - XM_011250436
RefSeq - NM_010320
RefSeq - XM_006539547
RefSeq - XM_006539548
RefSeq - XM_006539549
RefSeq Peptide - NP_034450
swissprot - P63078
swissprot - Q3UMY0
Ensembl - ENSMUSG00000063594
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gng8ENSDARG00000042970Danio rerio
 GNG8ENSG00000167414Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*ENSMUSG0000004300470
Gng4 / P50153 / guanine nucleotide binding protein (G protein), gamma 4 / P50150* / G protein subunit gamma 4*ENSMUSG0000002130360
Gng3 / P63216 / guanine nucleotide binding protein (G protein), gamma 3 / P63215* / G protein subunit gamma 3*ENSMUSG0000007165856
Gng7 / Q61016 / guanine nucleotide binding protein (G protein), gamma 7 / O60262* / G protein subunit gamma 7*ENSMUSG0000004824049
Gng12 / Q9DAS9 / guanine nucleotide binding protein (G protein), gamma 12 / Q9UBI6* / G protein subunit gamma 12*ENSMUSG0000003640249
Gng10 / Q9CXP8 / guanine nucleotide binding protein (G protein), gamma 10 / P50151* / G protein subunit gamma 10*ENSMUSG0000003860747
Gm5741 / G protein subunit gamma 14 / GNG14* / A0A1W2PPG7*ENSMUSG0000009584546
Gng5 / Q80SZ7 / guanine nucleotide binding protein (G protein), gamma 5 / P63218* / G protein subunit gamma 5*ENSMUSG0000006852343


Protein motifs (from Interpro)
Interpro ID Name
 IPR001770  G-protein, gamma subunit
 IPR015898  G-protein gamma-like domain
 IPR036284  G-protein gamma-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0035176 social behavior IMP
 biological_processGO:0043584 nose development IMP
 biological_processGO:0071444 cellular response to pheromone IMP
 cellular_componentGO:0005834 heterotrimeric G-protein complex IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA


Pathways (from Reactome)
Pathway description
Activation of G protein gated Potassium channels
Glucagon signaling in metabolic regulation
G-protein activation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
ADP signalling through P2Y purinoceptor 12
G beta:gamma signalling through PI3Kgamma
Prostacyclin signalling through prostacyclin receptor
Adrenaline,noradrenaline inhibits insulin secretion
Ca2+ pathway
G alpha (q) signalling events
G alpha (12/13) signalling events
G beta:gamma signalling through PLC beta
G alpha (s) signalling events
ADP signalling through P2Y purinoceptor 1
G alpha (i) signalling events
G alpha (z) signalling events
Glucagon-type ligand receptors
Thromboxane signalling through TP receptor
Vasopressin regulates renal water homeostasis via Aquaporins
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0003491 abnormal voluntary movement "anomalies in coordinated movements executed with a purpose and can be improved by learning and/or experience" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0003862 decreased aggression towards males "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards male mice " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0008779 abnormal maternal behavior "any response from the mother inconsistent with ability of young to thrive" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0009945 abnormal accessory olfactory bulb morphology "any structural anomaly of the forebrain region that coordinates sensory signaling arising from the vomeronasal organ; it is located on the dorsal-posterior portion of the main olfactory bulb, and the axons that leave the accessory olfactory bulb project to targets in the amygdala and hypothalamus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0011679 abnormal vomeronasal sensory neuron morphology "any structural anomaly of chemosensitive cells that innervate the vomernasal organ epithelium and are responsible for receiving and transmitting pheromone signals" [MGI:csmith]
Show

Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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