ENSMUSG00000071658


Mus musculus

Features
Gene ID: ENSMUSG00000071658
  
Biological name :Gng3
  
Synonyms : Gng3 / guanine nucleotide binding protein (G protein), gamma 3 / P63216
  
Possible biological names infered from orthology : G protein subunit gamma 3 / P63215
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 8836929
Gene end: 8839246
  
Corresponding Affymetrix probe sets: 10465820 (MoGene1.0st)   1417428_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000093978
NCBI entrez gene - 14704     See in Manteia.
MGI - MGI:102704
RefSeq - NM_010316
RefSeq Peptide - NP_034446
swissprot - P63216
Ensembl - ENSMUSG00000071658
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gng3ENSDARG00000009553Danio rerio
 GNG3ENSG00000162188Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*ENSMUSG0000004300472
Gng4 / P50153 / guanine nucleotide binding protein (G protein), gamma 4 / P50150* / G protein subunit gamma 4*ENSMUSG0000002130368
Gng12 / Q9DAS9 / guanine nucleotide binding protein (G protein), gamma 12 / Q9UBI6* / G protein subunit gamma 12*ENSMUSG0000003640257
Gng7 / Q61016 / guanine nucleotide binding protein (G protein), gamma 7 / O60262* / G protein subunit gamma 7*ENSMUSG0000004824055
Gng8 / P63078 / guanine nucleotide binding protein (G protein), gamma 8 / Q9UK08* / G protein subunit gamma 8*ENSMUSG0000006359452
Gm5741 / G protein subunit gamma 14 / GNG14* / A0A1W2PPG7*ENSMUSG0000009584548
Gng10 / Q9CXP8 / guanine nucleotide binding protein (G protein), gamma 10 / P50151* / G protein subunit gamma 10*ENSMUSG0000003860747
Gng5 / Q80SZ7 / guanine nucleotide binding protein (G protein), gamma 5 / P63218* / G protein subunit gamma 5*ENSMUSG0000006852345


Protein motifs (from Interpro)
Interpro ID Name
 IPR001770  G-protein, gamma subunit
 IPR015898  G-protein gamma-like domain
 IPR036284  G-protein gamma-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 cellular_componentGO:0005834 heterotrimeric G-protein complex ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0044297 cell body IDA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0003924 GTPase activity ISO
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0031702 type 1 angiotensin receptor binding IEA


Pathways (from Reactome)
Pathway description
Activation of G protein gated Potassium channels
Glucagon signaling in metabolic regulation
G-protein activation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
ADP signalling through P2Y purinoceptor 12
G beta:gamma signalling through PI3Kgamma
Prostacyclin signalling through prostacyclin receptor
Adrenaline,noradrenaline inhibits insulin secretion
Ca2+ pathway
G alpha (q) signalling events
G alpha (12/13) signalling events
G beta:gamma signalling through PLC beta
G alpha (s) signalling events
ADP signalling through P2Y purinoceptor 1
G alpha (i) signalling events
G alpha (z) signalling events
Glucagon-type ligand receptors
Thromboxane signalling through TP receptor
Vasopressin regulates renal water homeostasis via Aquaporins
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dysftm1Meho/Dysftm1Meho
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001496 audiogenic seizures "a reflex seizure triggered by loud noises" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dysftm1Meho/Dysftm1Meho
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gng3tm1.1Rbs/Gng3tm1.1Rbs
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lclat1tm1Arai/Lclat1tm1Arai
Genetic Background: C57BL/6-Lclat1tm1Arai

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dysftm1Meho/Dysftm1Meho
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gng3tm1.1Rbs/Gng3tm1.1Rbs
Genetic Background: involves: C57BL/6J * FVB/N

Allelic Composition: Gng3tm1.1Rbs/Gng3tm1.1Rbs,Gng7tm1Lex/Gng7tm1Lex
Genetic Background: B6.Cg-Gng7tm1Lex Gng3tm1.1Rbs

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gng3tm1.1Rbs/Gng3tm1.1Rbs,Gng7tm1Lex/Gng7tm1Lex
Genetic Background: B6.Cg-Gng7tm1Lex Gng3tm1.1Rbs

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gng3tm1.1Rbs/Gng3tm1.1Rbs,Gng7tm1Lex/Gng7tm1Lex
Genetic Background: B6.Cg-Gng7tm1Lex Gng3tm1.1Rbs

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Dysftm1Meho/Dysftm1Meho
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gng3tm1.1Rbs/Gng3tm1.1Rbs
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dysftm1Meho/Dysftm1Meho
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gng3tm1.1Rbs/Gng3tm1.1Rbs
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0009293 decreased inguinal fat pad weight 
Show

Allelic Composition: Dysftm1Meho/Dysftm1Meho
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gng3tm1.1Rbs/Gng3tm1.1Rbs
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0009305 decreased retroperitoneal fat pad weight 
Show

Allelic Composition: Dysftm1Meho/Dysftm1Meho
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gng3tm1.1Rbs/Gng3tm1.1Rbs
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0009358 environmentally induced seizures "relatively mild but sudden stimulation due to changes in ambient habitat including lighting, sounds, touching, and/ or moving cage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gng3tm1.1Rbs/Gng3tm1.1Rbs,Gng7tm1Lex/Gng7tm1Lex
Genetic Background: B6.Cg-Gng7tm1Lex Gng3tm1.1Rbs

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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