ENSMUSG00000068523


Mus musculus

Features
Gene ID: ENSMUSG00000068523
  
Biological name :Gng5
  
Synonyms : Gng5 / guanine nucleotide binding protein (G protein), gamma 5 / Q80SZ7
  
Possible biological names infered from orthology : G protein subunit gamma 5 / P63218
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: H2
Gene start: 146499807
Gene end: 146505572
  
Corresponding Affymetrix probe sets: 10434672 (MoGene1.0st)   10496822 (MoGene1.0st)   1423985_at (Mouse Genome 430 2.0 Array)   1425012_at (Mouse Genome 430 2.0 Array)   1436946_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000087485
Ensembl peptide - ENSMUSP00000113018
Ensembl peptide - ENSMUSP00000114014
NCBI entrez gene - 100043507     See in Manteia.
NCBI entrez gene - 14707     See in Manteia.
MGI - MGI:109164
RefSeq - NM_010318
RefSeq Peptide - NP_034448
swissprot - D3Z7Q3
swissprot - Q3UKC8
swissprot - Q80SZ7
Ensembl - ENSMUSG00000068523
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gng5ENSDARG00000039830Danio rerio
 GNG5ENSGALG00000027561Gallus gallus
 GNG5ENSG00000174021Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gng10 / Q9CXP8 / guanine nucleotide binding protein (G protein), gamma 10 / P50151* / G protein subunit gamma 10*ENSMUSG0000003860754
Gng7 / Q61016 / guanine nucleotide binding protein (G protein), gamma 7 / O60262* / G protein subunit gamma 7*ENSMUSG0000004824051
Gng12 / Q9DAS9 / guanine nucleotide binding protein (G protein), gamma 12 / Q9UBI6* / G protein subunit gamma 12*ENSMUSG0000003640250
Gng3 / P63216 / guanine nucleotide binding protein (G protein), gamma 3 / P63215* / G protein subunit gamma 3*ENSMUSG0000007165850
Gm5741 / G protein subunit gamma 14 / GNG14* / A0A1W2PPG7*ENSMUSG0000009584550
Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*ENSMUSG0000004300449
Gng4 / P50153 / guanine nucleotide binding protein (G protein), gamma 4 / P50150* / G protein subunit gamma 4*ENSMUSG0000002130346
Gng8 / P63078 / guanine nucleotide binding protein (G protein), gamma 8 / Q9UK08* / G protein subunit gamma 8*ENSMUSG0000006359444


Protein motifs (from Interpro)
Interpro ID Name
 IPR001770  G-protein, gamma subunit
 IPR015898  G-protein gamma-like domain
 IPR036284  G-protein gamma-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0072513 positive regulation of secondary heart field cardioblast proliferation IMP
 biological_processGO:2000179 positive regulation of neural precursor cell proliferation IMP
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005834 heterotrimeric G-protein complex IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031680 G-protein beta/gamma-subunit complex ISO
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0030165 PDZ domain binding IEA


Pathways (from Reactome)
Pathway description
Activation of G protein gated Potassium channels
Glucagon signaling in metabolic regulation
G-protein activation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
ADP signalling through P2Y purinoceptor 12
G beta:gamma signalling through PI3Kgamma
Prostacyclin signalling through prostacyclin receptor
Adrenaline,noradrenaline inhibits insulin secretion
Ca2+ pathway
G alpha (q) signalling events
G alpha (12/13) signalling events
G beta:gamma signalling through PLC beta
G alpha (s) signalling events
ADP signalling through P2Y purinoceptor 1
G alpha (i) signalling events
G alpha (z) signalling events
Glucagon-type ligand receptors
Thromboxane signalling through TP receptor
Vasopressin regulates renal water homeostasis via Aquaporins
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

 MP:0000270 abnormal heart tube morphology "malformed embryonic heart " [J:37888]
Show

Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

 MP:0003872 absent right ventricle "missing the lower right chamber of the heart" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

 MP:0003873 branchial arch hypoplasia "reduced size of the transient structures of the embryo that develop into regions of the head, neck and ears, due to reduced cell number" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

 MP:0011257 abnormal head fold morphology "any structural anomaly of the crescent-shaped, ventrally located fold of the embryonic disc at the future cephalic end of the developing embryo; it constitutes the first body fold, and initiates brain, foregut and heart development" [ISBN:0-683-40008-8, PMID:10791309]
Show

Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

 MP:0011395 decreased fetal cardiomyocyte proliferation "reduced ability of the differentiating cardiac muscle cell population to undergo expansion by cell division" [MGI:csmith]
Show

Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

 MP:0012278 abnormal cardiogenic mesoderm morphology "any structural anomaly of the splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium" [MGI:anna]
Show

Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

 MP:0012511 dilated aortic sac "abnormally stretched or widened aperture of the luminal space of the endothelial lined dilation that is located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates" [MGI:anna]
Show

Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

 MP:0013267 first pharyngeal arch hypoplasia "underdevelopment or reduced size of the first pharyngeal arch, usually due to reduced cell number" [MGI:anna]
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Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

 MP:0014044 absent cardiac outflow tract "absence of or complete failure to form the common arterial trunk that normally forms the aorta and pulmonary artery and the ventricular outflow regions" [MGI:anna]
Show

Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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